Protein Alignment nod and KIF17

DIOPT Version :10

• Sequence 1: NP_511125.2
• Gene: nod / 32107
• FlyBaseID: FBgn0002948
• Length: 666
• Species: Drosophila melanogaster
• Sequence 2: XP_047282102.1
• Gene: KIF17 / 57576
• HGNCID: 19167
• Length: 1063
• Species: Homo sapiens
• Alignment Length: 691
• Identity: 188/691 - (27%)
• Similarity: 285/691 - (41%)
• Gaps: 162/691 - (23%)

  Fly     8 AVRIAVREAPYRQFLGRRE--------------------PSVVQFPPWSDGKSLIVDQNEFHFDH 52
            ||::.||..|..|  ..||                    |.....||           .:|.||.
Human     5 AVKVVVRCRPMNQ--RERELRCQPVVTVDCARAQCCIQNPGAADEPP-----------KQFTFDG 56

  Fly    53 AFPATISQDEMYQALILPLVDKLLEGFQCTALAYGQTGTGKSYSM-GMTPPGEILPEHLGILPRA 116
            |:......:::|..:..|||:.:.||:..|..||||||:|||::| |:..|    |...||:|||
Human    57 AYHVDHVTEQIYNEIAYPLVEGVTEGYNGTIFAYGQTGSGKSFTMQGLPDP----PSQRGIIPRA 117

  Fly   117 LGDIFERVTARQENNKDAIQVYASFIEIYNEKPFDLLGSTPHM-------PMVAARCQRCTCLPL 174
            ...:||.|.. .||.|  ..|.||::|||||...||||:....       |......:..:...:
Human   118 FEHVFESVQC-AENTK--FLVRASYLEIYNEDVRDLLGADTKQKLELKEHPEKGVYVKGLSMHTV 179

  Fly   175 HSQADLHHILELGTRNRRVRPTNMNSNSSRSHAIVTIHV-------KSKTH--HSRMNIVDLAGS 230
            ||.|...||:|.|.:||.|..|.||.:|||||:|.||.:       :.|.|  ..::|:||||||
Human   180 HSVAQCEHIMETGWKNRSVGYTLMNKDSSRSHSIFTISIEMSAVDERGKDHLRAGKLNLVDLAGS 244

  Fly   231 EGVRRTGHEGVARQEGVNINLGLLSINKVVMSMAAGHTV-IPYRDSVLTTVLQASLTAQSYLTFL 294
            |...:||..|...:|...|||.|.::..|:.::..|... :|||||.||.:||.||...:....:
Human   245 ERQSKTGATGERLKEATKINLSLSALGNVISALVDGRCKHVPYRDSKLTRLLQDSLGGNTKTLMV 309

  Fly   295 ACISPHQCDLSETLSTLRFGTSAKKLRLNPMQVARQKQSLAARTTHVFR--QALCTSTAIKSNAA 357
            ||:||...:..|||||||:...||.:|..|......|.:|........:  :|:.|.....|:.:
Human   310 ACLSPADNNYDETLSTLRYANRAKNIRNKPRINEDPKDALLREYQEEIKKLKAILTQQMSPSSLS 374

  Fly   358 NHNSIVVPKSKYSTTK---PLSAVLHRTRSE--------------LGMTPKAKKRARELLELEET 405
            ...|..||.......:   |...:.|...:|              |....||::.:|..|| |:.
Human   375 ALLSRQVPPDPVQVEEKLLPQPVIQHDVEAEKQLIREEYEERLARLKADYKAEQESRARLE-EDI 438

  Fly   406 TLELSSIHIQDSSLSLLGFHSDSDKDRHLMPPPTGQEPRQASSQNSTLMGIVEETEPKESSKVQQ 470
            |...:|..::.|:|                     :|..:..::....:|::.:.|....::...
Human   439 TAMRNSYDVRLSTL---------------------EENLRKETEAVLQVGVLYKAEVMSRAEFAS 482

  Fly   471 SMVAPTV---PTTVRCQLFNTTISPIS-----LRASSSQRELSGIQP--------------MEET 513
            |...|..   .|.|:.::|:||.:..|     .:.||...||..::|              :|||
Human   483 SAEYPPAFQYETVVKPKVFSTTDTLPSDDVSKTQVSSRFAELPKVEPSKSEISLGSSESSSLEET 547

  Fly   514 VVA----SPQQP--------------------CLRRSVRLASSMRSQNY--GAIPKVMNLRRSTR 552
            .|:    .|::|                    ||.:.. ....:..|||  ...|:.:.|:   .
Human   548 SVSEAFPGPEEPSNVEVSMPTEESRSRYFLDECLGQEA-AGHLLGEQNYLPQEEPQEVPLQ---G 608

  Fly   553 LAGIREHATSVVVKNETDAIPHLRSTVQKKRTRNVKPAPKA 593
            |.|:::....|..|     :..|.|||.:      ..||:|
Human   609 LLGLQDPFAEVEAK-----LARLSSTVAR------TDAPQA 638

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nod	NP_511125.2	KISc	8..318	CDD:276812	122/347 (35%)
		ComEA	606..>645	CDD:441164
KIF17	XP_047282102.1	Motor_domain	4..335	CDD:473979	124/349 (36%)