Protein Alignment nod and kif1ab

DIOPT Version :10

• Sequence 1: NP_511125.2
• Gene: nod / 32107
• FlyBaseID: FBgn0002948
• Length: 666
• Species: Drosophila melanogaster
• Sequence 2: XP_009296795.1
• Gene: kif1ab / 566766
• ZFINID: ZDB-GENE-070912-480
• Length: 1799
• Species: Danio rerio
• Alignment Length: 788
• Identity: 196/788 - (24%)
• Similarity: 317/788 - (40%)
• Gaps: 194/788 - (24%)

  Fly     1 MEGAKLSAVRIAVREAPYR-QFLGRREPSVVQFPPWSDGKSLIV------DQNEFHFD-----HA 53
            |.||   :|::|||..|:. :.:|:....::|.   |...:.|:      :...|:||     |.
Zfish     1 MAGA---SVKVAVRVRPFNSREIGKDSKCIIQM---SGNTTTILNPKQPKENKSFNFDYSYWSHT 59

  Fly    54 FPATIS---QDEMYQALILPLVDKLLEGFQCTALAYGQTGTGKSYSMGMTPPGEILPEHLGILPR 115
            .|..::   |.::|:.:...::....||:.....||||||.||||:|    .|:...:..||:|.
Zfish    60 TPEDVNYACQKQVYRDIGEEMLLHAFEGYNVCIFAYGQTGAGKSYTM----MGKQEKDQEGIIPL 120

  Fly   116 ALGDIFERVTARQENNKDAIQVYASFIEIYNEKPFDLLG-------STPHMPMVAARCQRCTCLP 173
            ...|:|.::....:||. :..|..|::|||.|:..|||.       .....|::....:..:.|.
Zfish   121 LCEDLFTKINDNNDNNM-SYSVEVSYMEIYCERVRDLLNPKNKGNLRVREHPLMGPYVEDLSKLA 184

  Fly   174 LHSQADLHHILELGTRNRRVRPTNMNSNSSRSHAIVTIHVKSKTHH----------SRMNIVDLA 228
            :.|..|:..:::.|.:.|.|..||||..||||||:..|....|.|.          |::::||||
Zfish   185 VTSYNDIQDLMDSGNKARTVAATNMNETSSRSHAVFNIIFTQKQHDNDSENTTEKVSKISLVDLA 249

  Fly   229 GSEGVRRTGHEGVARQEGVNINLGLLSINKVVMSMA-------------AGHTVIPYRDSVLTTV 280
            |||....||.:|...:||.|||..|.::.||:.::|             ...:.|||||||||.:
Zfish   250 GSERADSTGAKGTRLKEGANINKSLTTLGKVISALAEMDSAPNKNKKKKKVESFIPYRDSVLTWL 314

  Fly   281 LQASLTAQSYLTFLACISPHQCDLSETLSTLRFGTSAKKLRLNPM-------QVARQ-KQSLAAR 337
            |:.:|...|....:|.:||...:..|||||||:...||::|.|.:       ::.|: |:.:|..
Zfish   315 LRENLGGNSRTAMVAALSPADINYDETLSTLRYADRAKQIRCNAVINEDPNNRLVRELKEEVARL 379

  Fly   338 TTHVFRQALCTSTAIKSN-AANHNSI--VVPKSKYST----------TKPLSAVLHRTRS----- 384
            ...::.|.|.......|| .||.:||  |..:..:||          :..|||:..|..|
Zfish   380 KDLLYAQGLGDIIENLSNYKANISSIQAVNQRGDFSTVTNAMTGMSPSPSLSALTSRVGSISSLH 444

  Fly   385 -ELGMTPKAKKRARELLELEETTLELS-----------SIHIQ-DSSLSLLGFHSDSD------- 429
             .:..:|.:::....|.|.|:...||:           :|.:: ::.|:.:|.....|
Zfish   445 DRIMFSPGSEEAIERLKETEKIIAELNETWEEKLRRTEAIRMEREALLAEMGVAMREDGGTVGVF 509

  Fly   430 ---KDRHLMPPPTGQEP-------------------RQASSQ-----------------NSTLMG 455
               |..||:  ...::|                   ..|||:                 .||...
Zfish   510 SPKKTPHLV--NLNEDPLMSECLLYYIKDGITKVGREDASSRQDIVLSGHFIKDEHCIFTSTTNA 572

  Fly   456 IVEET---EPKESSKVQQSMVAPTVPTTV---------------------------RCQLFNTTI 490
            |.|.|   ||.|.::...:....|.||.:                           |....:|.:
Zfish   573 IGEGTVVLEPCEGAETYVNGKRVTEPTVLKSGNRIIMGKSHVFRFNDPEQARQDRERTPCADTPV 637

  Fly   491 SPISLRASSSQREL---SGI---QPMEETVVASPQQPCLRRSVRLASSMRSQNYGAIPKVMNLRR 549
            .|:..  :.:||||   .||   |.|::.:.....|  .|:....||::..|        ..|..
Zfish   638 EPVDW--AFAQRELLEKQGIDMKQEMDQRLQELEDQ--YRKEREEASNLLEQ--------QRLDY 690

  Fly   550 STRLAGIREHATSVVVKNETDAIPHLRSTV--QKKRTRNVKPAPKAWMANNTKCFLDLLNNGNVK 612
            .::|..:::...|......|:....|...|  .|:.|.....|.:.|.........||| .||..
Zfish   691 ESKLEALQKQVNSRYYPETTEEEEELEDEVPWTKRETELALWAFRKWRFYQFTSLRDLL-WGNAI 754

  Fly   613 QLQEIPGI 620
            .|:|...|
Zfish   755 FLKEANAI 762

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nod	NP_511125.2	KISc	8..318	CDD:276812	108/354 (31%)
		ComEA	606..>645	CDD:441164	6/15 (40%)
kif1ab	XP_009296795.1	KISc_KIF1A_KIF1B	4..361	CDD:276816	113/367 (31%)
		Kinesin_assoc	358..538	CDD:465047	33/181 (18%)
		FHA	514..628	CDD:469597	17/115 (15%)
		ERM_helical	647..>702	CDD:466641	14/64 (22%)
		KIF1B	828..875	CDD:463574
		DUF3694	1273..1428	CDD:463599
		PH_KIFIA_KIFIB	1680..1782	CDD:269939