DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nod and kif5ba

DIOPT Version :9

Sequence 1:	NP_001285129.1	Gene:	nod / 32107	FlyBaseID:	FBgn0002948	Length:	666	Species:	Drosophila melanogaster
Sequence 2:	XP_005171465.1	Gene:	kif5ba / 563459	ZFINID:	ZDB-GENE-070629-2	Length:	969	Species:	Danio rerio

Alignment Length:	663	Identity:	173/663 - (26%)
Similarity:	286/663 - (43%)	Gaps:	142/663 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 PPWSDGKSLIVDQNEFHFDHAFPATISQDEMYQALILPLVDKLLEGFQCTALAYGQTGTGKSYSM 97
            |.:....|:::....:.||..|.:..:|:::|.|....:|..:|.|:..|..|||||.:||:::|
Zfish    31 PNFQGQDSVVIGGKPYVFDRVFQSNTTQEQVYTACAQQIVKDVLAGYNGTIFAYGQTSSGKTHTM 95

  Fly    98 GMTPPGEIL-PEHLGILPRALGDIFERVTARQENNKDAIQVYASFIEIYNEKPFDLLGSTP---- 157
                .|.:. .:.:||:||.:.|||..:.:..||.:..|:|  |:.|||.:|..|||..:.
Zfish    96 ----EGNLHDTDGMGIIPRIVQDIFNYIYSMDENLEFHIKV--SYFEIYLDKIRDLLDVSKTNLS 154

  Fly   158 ------HMPMVAARCQRCTCLPLHSQADLHHILELGTRNRRVRPTNMNSNSSRSHAIVTIHVKSK 216
                  .:|.|....:|..|.|    .::...::.|..||.|..||||.:|||||:|..|:||.:
Zfish   155 VHEDKNRVPYVKGCTERFVCSP----EEVMDTIDEGKSNRHVAVTNMNEHSSRSHSIFLINVKQE 215

  Fly   217 THHS------RMNIVDLAGSEGVRRTGHEGVARQEGVNINLGLLSINKVVMSMAAGHTVIPYRDS 275
            ...:      ::.:|||||||.|.:||.||....|..|||..|.|:..|:.::|.|.|.:|||||
Zfish   216 NTQTEQKLSGKLYLVDLAGSEKVSKTGAEGAVLDEAKNINKSLSSLGNVISALAEGSTYVPYRDS 280

  Fly   276 VLTTVLQASLTAQSYLTFLACISPHQCDLSETLSTLRFGTSAKKLR----LNPMQVARQKQSLAA 336
            .:|.:||.||......|.:.|.||...:.:||.|||.||..||.::    :|....|.|.:....
Zfish   281 KMTRILQDSLGGNCRTTIVICCSPSAFNEAETKSTLMFGQRAKTIKNTVCVNVELTAEQWKKKYE 345

  Fly   337 RTTHVFRQALCTSTAIKSNAAN--HNSIVVP----------------------KSKYSTT---KP 374
            :.....:....|.|.:: |..|  .|...||                      ..|:::|   .|
Zfish   346 KERERNKSLRNTITWLE-NELNRWRNGETVPAEEQYDKEKVNAEVLALDNTINNDKFASTPSMPP 409

  Fly   375 LSAVL---------HRTRSELGMTPK---------------AKKRARELLELEETTLELSSIHIQ 415
            :..:|         .:...|||...|               .:|..:::|:.||  |..||....
Zfish   410 MPGMLGTRLTGVEKDKCEVELGKLYKQLDDKDEEINQQSQLVEKLKQQMLDQEE--LLASSRRDH 472

  Fly   416 D---SSLSLLGFHSDSDKD--RHLMP---------PPTGQE-----------PRQASSQNSTLMG 455
            |   :.|:.|...:::.|:  :.::.         ....||           ..:.|.::|||..
Zfish   473 DNLQAELTRLQLENEASKEEVKEVLQALEELAVNYDQKSQEVEDKTKEFEALSEELSQKSSTLAS 537

  Fly   456 IVEETEP-KESSKVQQSMVAPTVPTTVRCQLFNTTISPISLRASSS---QRELSGIQPMEETV-- 514
            |..|.:. ||.:..|:..|...:.:.::      .::.|.:...::   |.|.||:...|.||
Zfish   538 IDSELQKLKEMANHQKKRVTEMMSSLLK------DLTEIGIAVGNNDIKQHEGSGLIDEEFTVAR 596

  Fly   515 -----VASPQQPCLRRSVRLASSMRSQNYGAIPKVMNLRRSTRLAG----IREHATSVVVKNETD 570
                 :.|..:..::|..:|.::....|     |.|: .....||.    |.:|...  :|:.|:
Zfish   597 LYISKMKSEVKSMVKRCKQLENTQSESN-----KKMD-ESDKELAACQLRISQHEAK--IKSLTE 653

  Fly   571 AIPHLRSTVQKKR 583
               :|::..||||
Zfish   654 ---YLQNVEQKKR 663

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nod	NP_001285129.1	KISc	8..325	CDD:214526	108/312 (35%)
		KISc	8..318	CDD:276812	105/301 (35%)
		ComEA	540..648	CDD:224472	13/48 (27%)
kif5ba	XP_005171465.1	KISc_KHC_KIF5	6..325	CDD:276820	107/303 (35%)
		KISc	9..332	CDD:214526	107/310 (35%)
		COG5281	<305..>569	CDD:227606	50/272 (18%)
		DUF4337	<467..>536	CDD:290935	11/68 (16%)
		TACC	474..679	CDD:282818	40/207 (19%)
		TMPIT	603..>691	CDD:285135	17/72 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910