DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nod and KIF21A

DIOPT Version :9

Sequence 1:	NP_001285129.1	Gene:	nod / 32107	FlyBaseID:	FBgn0002948	Length:	666	Species:	Drosophila melanogaster
Sequence 2:	NP_001365368.1	Gene:	KIF21A / 55605	HGNCID:	19349	Length:	1675	Species:	Homo sapiens

Alignment Length:	621	Identity:	158/621 - (25%)
Similarity:	263/621 - (42%)	Gaps:	150/621 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 SAVRIAVREAPYRQFLGRR-------------EPSVVQFPPWSDGKSLIVDQNEFHFDHAFPATI 58
            |:||:|||..|  |....:             ||.|..      ||     ...|.||:.|....
Human     8 SSVRVAVRIRP--QLAKEKIEGCHICTSVTPGEPQVFL------GK-----DKAFTFDYVFDIDS 59

  Fly    59 SQDEMYQALILPLVDKLLEGFQCTALAYGQTGTGKSYSMGMTPPGEILPEHLGILPRALGDIFER 123
            .|:::|...|..|::...||:..|..||||||.||:|:||......|:.|.|||:.||:..:|:.
Human    60 QQEQIYIQCIEKLIEGCFEGYNATVFAYGQTGAGKTYTMGTGFDVNIVEEELGIISRAVKHLFKS 124

  Fly   124 VTARQ----ENNKDA--IQVYASFIEIYNEKPFDLLGSTPHMPMVAARCQR-------------- 168
            :..::    :|...|  .:|.|.|:|:|||:..||..:|..   :.|:.::
Human   125 IEEKKHIAIKNGLPAPDFKVNAQFLELYNEEVLDLFDTTRD---IDAKSKKSNIRIHEDSTGGIY 186

  Fly   169 ---CTCLPLHSQADLHHILELGTRNRRVRPTNMNSNSSRSHAIVTIHV----------------- 213
               .|...:::::::...|:||..:|....|.||..|||||||.||||
Human   187 TVGVTTRTVNTESEMMQCLKLGALSRTTASTQMNVQSSRSHAIFTIHVCQTRVCPQIDADNATDN 251

  Fly   214 ----------KSKTHHSRMNIVDLAGSEGVRRTGHEGVARQEGVNINLGLLSINKVVMSMA---- 264
                      :.:|..::.:.|||||||.::|||..|...:||::||.|||::..|:.::.
Human   252 KIISESAQMNEFETLTAKFHFVDLAGSERLKRTGATGERAKEGISINCGLLALGNVISALGDKSK 316

  Fly   265 -AGHTVIPYRDSVLTTVLQASLTAQSYLTFLACISPHQCDLSETLSTLRFGTSAK----KLRLNP 324
             |.|  :|||||.||.:||.||...|....:||:||...|..|||:||::...|:    |:.:|.
Human   317 RATH--VPYRDSKLTRLLQDSLGGNSQTIMIACVSPSDRDFMETLNTLKYANRARNIKNKVMVNQ 379

  Fly   325 MQVARQKQSLAARTTHVFRQALCTSTAIKSNAANHNSIVVPKSKYSTTKPL-------------- 375
            .:.::|..:|.:..|.:..:.:                     :|.|.|.:
Human   380 DRASQQINALRSEITRLQMELM---------------------EYKTGKRIIDEEGVESINDMFH 423

  Fly   376 -SAVLHRTRSELGMTPKAKKRARELLELEETTLELSSIHIQDSSLSLLGFHSDSDKDRHLMPPPT 439
             :|:|....:.|.:..||.:...:.|....|.|.                   ||:..|:: ...
Human   424 ENAMLQTENNNLRVRIKAMQETVDALRSRITQLV-------------------SDQANHVL-ARA 468

  Fly   440 GQEPRQASSQNSTLMGIVEETEPK--ESSKVQQSMVAPTVPTTVRCQLF--NTTISPISLRASSS 500
            |:...:.|:...:.:..:|:...|  ||..|.:::.......|.|...|  ::|.||..|.:...
Human   469 GEGNEEISNMIHSYIKEIEDLRAKLLESEAVNENLRKNLTRATARAPYFSGSSTFSPTILSSDKE 533

  Fly   501 QRELSGIQPMEETVVASPQQPCLRRSVRLASSMRSQ 536
            ..|:..:...:...:...::...:|..:|..|.|.:
Human   534 TIEIIDLAKKDLEKLKRKEKRKKKRLQKLEESNREE 569

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nod	NP_001285129.1	KISc	8..325	CDD:214526	121/388 (31%)
		KISc	8..318	CDD:276812	118/377 (31%)
		ComEA	540..648	CDD:224472
KIF21A	NP_001365368.1	KISc_KIF4	8..372	CDD:276823	120/381 (31%)
		Cast	<364..836	CDD:401982	39/247 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	556..641		4/14 (29%)
		Smc	<644..1004	CDD:224117
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	779..804
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	841..881
		Rcc_KIF21A	936..1017	CDD:410204
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1116..1138
		Interaction with KANK1 and KANK2. /evidence=ECO:0000269\|PubMed:29183992	1146..1167
		WD40	1340..1653	CDD:238121
		WD 1	1346..1383
		WD 2	1386..1424
		WD40 repeat	1391..1450	CDD:293791
		WD 3	1450..1488
		WD40 repeat	1456..1491	CDD:293791
		WD 4	1491..1533
		WD40 repeat	1496..1540	CDD:293791
		WD 5	1542..1579
		WD40 repeat	1548..1581	CDD:293791
		WD 6	1583..1622
		WD40 repeat	1588..1624	CDD:293791
		WD 7	1625..1662
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0244
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810