DRSC/TRiP Functional Genomics Resources

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Protein Alignment nod and KIF21A

DIOPT Version :10

Sequence 1:NP_511125.2 Gene:nod / 32107 FlyBaseID:FBgn0002948 Length:666 Species:Drosophila melanogaster
Sequence 2:NP_001365368.1 Gene:KIF21A / 55605 HGNCID:19349 Length:1675 Species:Homo sapiens


Alignment Length:621 Identity:158/621 - (25%)
Similarity:263/621 - (42%) Gaps:150/621 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly     7 SAVRIAVREAPYRQFLGRR-------------EPSVVQFPPWSDGKSLIVDQNEFHFDHAFPATI 58
            |:||:|||..|  |....:             ||.|..      ||     ...|.||:.|....
Human     8 SSVRVAVRIRP--QLAKEKIEGCHICTSVTPGEPQVFL------GK-----DKAFTFDYVFDIDS 59

  Fly    59 SQDEMYQALILPLVDKLLEGFQCTALAYGQTGTGKSYSMGMTPPGEILPEHLGILPRALGDIFER 123
            .|:::|...|..|::...||:..|..||||||.||:|:||......|:.|.|||:.||:..:|:.
Human    60 QQEQIYIQCIEKLIEGCFEGYNATVFAYGQTGAGKTYTMGTGFDVNIVEEELGIISRAVKHLFKS 124

  Fly   124 VTARQ----ENNKDA--IQVYASFIEIYNEKPFDLLGSTPHMPMVAARCQR-------------- 168
            :..::    :|...|  .:|.|.|:|:|||:..||..:|..   :.|:.::              
Human   125 IEEKKHIAIKNGLPAPDFKVNAQFLELYNEEVLDLFDTTRD---IDAKSKKSNIRIHEDSTGGIY 186

  Fly   169 ---CTCLPLHSQADLHHILELGTRNRRVRPTNMNSNSSRSHAIVTIHV----------------- 213
               .|...:::::::...|:||..:|....|.||..|||||||.||||                 
Human   187 TVGVTTRTVNTESEMMQCLKLGALSRTTASTQMNVQSSRSHAIFTIHVCQTRVCPQIDADNATDN 251

  Fly   214 ----------KSKTHHSRMNIVDLAGSEGVRRTGHEGVARQEGVNINLGLLSINKVVMSMA---- 264
                      :.:|..::.:.|||||||.::|||..|...:||::||.|||::..|:.::.    
Human   252 KIISESAQMNEFETLTAKFHFVDLAGSERLKRTGATGERAKEGISINCGLLALGNVISALGDKSK 316

  Fly   265 -AGHTVIPYRDSVLTTVLQASLTAQSYLTFLACISPHQCDLSETLSTLRFGTSAK----KLRLNP 324
             |.|  :|||||.||.:||.||...|....:||:||...|..|||:||::...|:    |:.:|.
Human   317 RATH--VPYRDSKLTRLLQDSLGGNSQTIMIACVSPSDRDFMETLNTLKYANRARNIKNKVMVNQ 379

  Fly   325 MQVARQKQSLAARTTHVFRQALCTSTAIKSNAANHNSIVVPKSKYSTTKPL-------------- 375
            .:.::|..:|.:..|.:..:.:                     :|.|.|.:              
Human   380 DRASQQINALRSEITRLQMELM---------------------EYKTGKRIIDEEGVESINDMFH 423

  Fly   376 -SAVLHRTRSELGMTPKAKKRARELLELEETTLELSSIHIQDSSLSLLGFHSDSDKDRHLMPPPT 439
             :|:|....:.|.:..||.:...:.|....|.|.                   ||:..|:: ...
Human   424 ENAMLQTENNNLRVRIKAMQETVDALRSRITQLV-------------------SDQANHVL-ARA 468

  Fly   440 GQEPRQASSQNSTLMGIVEETEPK--ESSKVQQSMVAPTVPTTVRCQLF--NTTISPISLRASSS 500
            |:...:.|:...:.:..:|:...|  ||..|.:::.......|.|...|  ::|.||..|.:...
Human   469 GEGNEEISNMIHSYIKEIEDLRAKLLESEAVNENLRKNLTRATARAPYFSGSSTFSPTILSSDKE 533

  Fly   501 QRELSGIQPMEETVVASPQQPCLRRSVRLASSMRSQ 536
            ..|:..:...:...:...::...:|..:|..|.|.:
Human   534 TIEIIDLAKKDLEKLKRKEKRKKKRLQKLEESNREE 569

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nodNP_511125.2 KISc 8..318 CDD:276812 118/377 (31%)
ComEA 606..>645 CDD:441164
KIF21ANP_001365368.1 KISc_KIF4 8..372 CDD:276823 120/381 (31%)
Cast <364..836 CDD:431111 39/247 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 556..641 4/14 (29%)
EnvC 640..>860 CDD:443969
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 779..804
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 841..881
Rcc_KIF21A 936..1017 CDD:410204
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1116..1138
Interaction with KANK1 and KANK2. /evidence=ECO:0000269|PubMed:24120883, ECO:0000269|PubMed:29183992 1146..1167
WD40 1340..1653 CDD:238121
WD 1 1346..1383
WD 2 1386..1424
WD40 repeat 1391..1450 CDD:293791
WD 3 1450..1488
WD40 repeat 1456..1491 CDD:293791
WD 4 1491..1533
WD40 repeat 1496..1540 CDD:293791
WD 5 1542..1579
WD40 repeat 1548..1581 CDD:293791
WD 6 1583..1622
WD40 repeat 1588..1624 CDD:293791
WD 7 1625..1662
Blue background indicates that the domain is not in the aligned region.

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