DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nod and kif11

DIOPT Version :9

Sequence 1:	NP_001285129.1	Gene:	nod / 32107	FlyBaseID:	FBgn0002948	Length:	666	Species:	Drosophila melanogaster
Sequence 2:	NP_001016116.2	Gene:	kif11 / 548870	XenbaseID:	XB-GENE-978999	Length:	1067	Species:	Xenopus tropicalis

Alignment Length:	743	Identity:	183/743 - (24%)
Similarity:	311/743 - (41%)	Gaps:	164/743 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 VRIAVREAPYRQFLGRREPSVVQFPPWSDGKSLIV---------DQNEFHFDHAFPATISQDEMY 64
            :::.||..|:.| |.|:..|.......:..|.:.|         .:..:.||..|.....|.::|
Frog    19 IQVVVRCRPFNQ-LERKASSHSVLECDAPRKEVCVRTGGINDKLGKKTYTFDMVFGPAAKQIDVY 82

  Fly    65 QALILPLVDKLLEGFQCTALAYGQTGTGKSYSMGMTPPGEILPEH---------LGILPRALGDI 120
            ::::.|::|:::.|:.||..|||||||||:::|    .||...:.         .||:||.|..|
Frog    83 RSVVCPILDEVIMGYNCTVFAYGQTGTGKTFTM----EGERSADEEFTWEQDPLAGIIPRTLHQI 143

  Fly   121 FERVTARQENNKDAIQVYASFIEIYNEKPFDLLGSTPHMPMVAARCQR--------------CTC 171
            ||:::   ||..: ..|..|.:|||||:.||||..:|.   |..|.|.              ...
Frog   144 FEKLS---ENGTE-FSVKVSLLEIYNEELFDLLSPSPD---VGERLQMFDDPRNKRGVIIKGLEE 201

  Fly   172 LPLHSQADLHHILELGTRNRRVRPTNMNSNSSRSHAI--VTIHVKSKT-------HHSRMNIVDL 227
            :.:|::.:::||||.|...|:...|.||:.|||||::  ||||:|..|       ...::|:|||
Frog   202 VSVHNKDEVYHILERGAARRKTASTLMNAYSSRSHSVFSVTIHMKETTVDGEELVKIGKLNLVDL 266

  Fly   228 AGSEGVRRTGHEGVARQEGVNINLGLLSINKVVMSMAAGHTVIPYRDSVLTTVLQASLTAQSYLT 292
            ||||.:.|:|......:|..|||..||::.:|:.::......||||:|.||.:||.||..::..:
Frog   267 AGSENIGRSGAVDKRAREAGNINQSLLTLGRVITALVERAPHIPYRESKLTRILQDSLGGRTKTS 331

  Fly   293 FLACISPHQCDLSETLSTLRFGTSAKKLRLNP----------------MQVARQKQSLA-ARTTH 340
            .:|.:||...:|.||:|||.:...||.:...|                .::.|.|:.|| ||..:
Frog   332 IIATVSPASINLEETVSTLEYANRAKNIMNKPEVNQKLTKRALIKEYTEEIERLKRDLATAREKN 396

  Fly   341 ----------------VFRQALCTS-----TAIKSNAANHNSIVVPKSKYSTTKPLSAVLHRTRS 384
                            :.::.:.|.     ||::......|.:.....|  ..:..:.:|.....
Frog   397 GVYLSNENYEQLQGKVLSQEEIITEYTEKITAMEEEIKRINELFAENKK--ELEECTTILQCKEK 459

  Fly   385 ELGMTPKAKKRARELLELEE---TTLELS--SIH---------IQDSSLSLLGFHSDSDKDRHLM 435
            ||..|.|....::|.|..|.   |.||.:  .:|         ::::|..:.|.|:..|:.|.:.
Frog   460 ELEETQKNLHESKEQLAQEAFVVTALETTEKKLHGTANKLLTTVRETSKDVSGLHAKLDRKRAVD 524

  Fly   436 PPPTGQEPRQASSQNSTLMGIVEETEPKESSKVQQSMVAPTVPTTVRCQLFNTTISPISLRASSS 500
            ...| |.....:.|.:....::|.:..:.|.| ||.|:  ...|.....|...:.:.:|:.|::.
Frog   525 QHNT-QVHENFAEQMNKRFSVIERSVDEYSVK-QQGML--DFYTNSIDDLLGASSAALSVTATAV 585

  Fly   501 QRELSGIQPMEETVVASPQQPCLRRSVRLASSMRSQNYGAIPKVMNLRRSTRLAGIREHATSVVV 565
            .:..:.:|......|:......|::     .::.||....:.|:|           ..|.|.:..
Frog   586 AKSFTSVQETVSEKVSHSVDEILKQ-----ETLSSQAKDDLQKLM-----------AAHRTGLEQ 634

  Fly   566 KNETDAIPHLRSTVQKKRTRNVKPAPKAWMANNTKCFLDLLNNGNVKQLQEIPGIGPK------- 623
            ...||.:|.:.:.:.                         ||:.....||....:..|
Frog   635 ALRTDLLPVVTAVLN-------------------------LNSHLSHCLQNFQAVADKIDSHKEE 674

  Fly   624 -----SAFSLALHRSRLGCFENLFQVKS 646
                 :..|.:|||.||.....|..::|
Frog   675 MNSFFTEHSRSLHRLRLDSGSALSSIQS 702

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nod	NP_001285129.1	KISc	8..325	CDD:214526	117/372 (31%)
		KISc	8..318	CDD:276812	114/349 (33%)
		ComEA	540..648	CDD:224472	20/119 (17%)
kif11	NP_001016116.2	KISc_BimC_Eg5	16..368	CDD:276815	117/360 (33%)
		KISc	18..366	CDD:214526	117/358 (33%)
		DUF342	<325..446	CDD:302792	23/122 (19%)
		Microtub_bind	927..1066	CDD:290642
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1048..1067
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910