DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nod and kif7

DIOPT Version :9

Sequence 1:	NP_001285129.1	Gene:	nod / 32107	FlyBaseID:	FBgn0002948	Length:	666	Species:	Drosophila melanogaster
Sequence 2:	NP_001014816.1	Gene:	kif7 / 544651	ZFINID:	ZDB-GENE-050307-1	Length:	1363	Species:	Danio rerio

Alignment Length:	679	Identity:	162/679 - (23%)
Similarity:	274/679 - (40%)	Gaps:	142/679 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 SAVRIAVREAPY--RQFLGRREPSVVQFPPWSDGKSLIVDQNEFHFDHAFPATISQDEMYQALIL 69
            |||::|||..|.  ::.|...|..:...|  .:.:..:.:...||.|..|....:|:|:|...:.
Zfish    14 SAVQVAVRVRPLLPKEILHSHESCITSDP--EERRVTLGNDRHFHCDFVFEDGSTQEEVYTNCVQ 76

  Fly    70 PLVDKLLEGFQCTALAYGQTGTGKSYSMGMTPPGEILPEHLGILPRALGDIFERVTARQENNKDA 134
            ||::....||..|..||||||:||:|::|.........:..||:|||:.:||:.:   .||:...
Zfish    77 PLIEAFFHGFNATVSAYGQTGSGKTYTIGEASISAFRDDEQGIIPRAVAEIFKLL---DENDLID 138

  Fly   135 IQVYASFIEIYNEKPFDLL-----GSTPHM------PMVAARCQRCTCLPLHSQADLHHILELGT 188
            ..|..|::|:|.|...|||     ....|:      .:|....:.|   .:....::..:||.|.
Zfish   139 FSVRVSYMEVYKEVFRDLLEVETASKDIHIREDERGNVVLCGVKEC---EVEGLDEVLSLLESGK 200

  Fly   189 RNRRVRPTNMNSNSSRSHAIVTIHVKSKTHHSR------------MNIVDLAGSEGVRRTGHEGV 241
            ..|....|.||.:|||||.|.|:.::.:...||            .:.|||||||.:.:||:.|.
Zfish   201 TARHTGATQMNPHSSRSHTIFTVLMEQRRGGSRAANGSVQILSSKFHFVDLAGSERILKTGNTGE 265

  Fly   242 ARQEGVNINLGLLSINKVVMSMA---AGHTVIPYRDSVLTTVLQASLTAQSYLTFLACISPHQCD 303
            ..:|.:.||.|||.:..|:.::.   ...|.||||||.:|.:|:.||...:....:|||||...|
Zfish   266 RLKESIQINSGLLVLGNVIGALGDPKRKGTHIPYRDSKITRILKDSLGGNAKTLMIACISPSSSD 330

  Fly   304 LSETLSTLRFGTSAKKLRLNPMQVARQKQSLAARTTHVFRQALCTSTAIKSNAANHNSIVVPKSK 368
            ..|:|:||.:...|:.::.......|.:..   |...:..|......|:::...:...|:.....
Zfish   331 FDESLNTLNYAKRARNIQNRATVNCRGEPD---RIEGLELQIKALRRALENRQRSETRIIARSDP 392

  Fly   369 YSTTKPLSAVLHRTRSELGMTPKAKKRARELL-ELE-ETTLE----------LSSIHIQDSSLSL 421
            ....:|....:.:.::|..........|..|| ||: |.||.          |..:..:.|.|:.
Zfish   393 EKRLRPFEVDVRKLQAESAHYRTCTDSAYRLLTELQGEGTLNAGQILRVKEWLCGVEEERSGLTS 457

  Fly   422 L-----GFHSDSDKDRHLMPPPTGQEPRQASSQN----------------STLMGIVEETE---- 461
            .     |..|.|.:|      .|..:.|||...|                |.|...:::.|
Zfish   458 ASGLDSGIESSSTED------STALKRRQAVLNNQDLVKEDWRGEREDYTSQLQAQIQQLEQENT 516

  Fly   462 -------------PKESSKV--QQSMVAPTVPTTVRCQLFNTTISPISLRASSSQRELSGIQPME 511
                         .::|.|:  ||.::|                   .|.:..:|...:|...::
Zfish   517 DFLVALEDAMEQYKQQSDKLQEQQDLIA-------------------ELHSLLAQPGGAGFLHLK 562

  Fly   512 E--------TVVASPQQ---PC-------LRRSVRLASSMRSQNYGAIPKVMNLRRSTRLAGIRE 558
            :        :::.:|.:   ||       |.|.:.:.:|:.|.:|....:......:|.....|
Zfish   563 QRPHTAPINSLLQTPDRLTPPCDSDVGRSLARQLDVGASVDSSSYSEQTQWDGTHGNTHCESSR- 626

  Fly   559 HATSVVVKNETDAIPHLRSTVQKKRTRNV 587
                   |...|...|:::|..|:::.||
Zfish   627 -------KLNRDEDGHMQTTRDKRKSINV 648

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nod	NP_001285129.1	KISc	8..325	CDD:214526	106/344 (31%)
		KISc	8..318	CDD:276812	105/337 (31%)
		ComEA	540..648	CDD:224472	9/48 (19%)
kif7	NP_001014816.1	KISc_KIF4	14..348	CDD:276823	107/341 (31%)
		KISc	15..354	CDD:214526	106/346 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	603..642		8/46 (17%)
		PspA_IM30	716..924	CDD:281941
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1314..1346
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0244
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900