DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nod and cmet

DIOPT Version :9

Sequence 1:	NP_001285129.1	Gene:	nod / 32107	FlyBaseID:	FBgn0002948	Length:	666	Species:	Drosophila melanogaster
Sequence 2:	NP_524993.3	Gene:	cmet / 53561	FlyBaseID:	FBgn0040232	Length:	2189	Species:	Drosophila melanogaster

Alignment Length:	569	Identity:	148/569 - (26%)
Similarity:	242/569 - (42%)	Gaps:	141/569 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MEGAKLSAVRIAVREAPYRQFLGRREPSVVQFPPWSDGKSL-IVDQN--EFHFDHAFPATISQDE 62
            |.....|::::.::..|.       ||.:.......:.:|: :.|.:  .:.||:.|....|..|
  Fly     1 MSAKNASSIQVCIKVRPC-------EPGLTSLWQVKERRSIHLADSHAEPYVFDYVFDEGASNQE 58

  Fly    63 MYQALILPLVDKLLEGFQCTALAYGQTGTGKSYSMGMTPPGEILPEHLGILPRALGDIFERVTAR 127
            ::..:...:|...::||..|..|||||.:||:|:|    .|:  .::.|::..|..:||:::::
  Fly    59 VFDRMAKHIVHACMQGFNGTIFAYGQTSSGKTYTM----MGD--EQNPGVMVLAAKEIFQQISS- 116

  Fly   128 QENNKDAIQVYASFIEIYNEKPFDLLGSTPH--------MPMVAARCQRCTCLPLHSQADLHHIL 184
             |..:|.: :...:|||||||.:|||.....        ..:|...|:.|.   :.|:.||..:|
  Fly   117 -ETERDFL-LRVGYIEIYNEKIYDLLNKKNQDLKIHESGNGIVNVNCEECI---ITSEVDLLRLL 176

  Fly   185 ELGTRNRRVRPTNMNSNSSRSHAIVTIHVKS-KTHHSR--------MNIVDLAGSEGVRRTGHEG 240
            .||.:.|.|..||||..|||||||..|.::| |:.||.        :|:|||||||...:||..|
  Fly   177 CLGNKERTVGETNMNERSSRSHAIFKIIIESRKSDHSDDDAVIQSVLNLVDLAGSERADQTGARG 241

  Fly   241 VARQEGVNINLGLLSINKVVMSMA--AGHTVIPYRDSVLTTVLQASLTAQSYLTFLACISPHQCD 303
            ...:||.:||..||.::.|:.|::  |.:....||||.||.:|||||...::.:.:..|.|  ..
  Fly   242 ARLKEGGHINKSLLFLSNVIKSLSENADNRFTNYRDSKLTRILQASLGGNAFTSIICTIKP--SI 304

  Fly   304 LSETLSTLRFGTSAKKLRLNPMQVARQKQSLAARTTHVFRQALCTSTAIKSNAANHNSIVVPKSK 368
            :.|:.|||.|.|.|||:|:.| ||                                |.:|   |.
  Fly   305 MEESQSTLSFATRAKKIRIKP-QV--------------------------------NEMV---SD 333

  Fly   369 YSTTKPLSAVLHRTRSELGMTPKAKKRARELLELEETTLELSSIHIQDSSLSLLGFHSDSDKDRH 433
            .:..|.|...:...:.:|....:..:..:::..||.        .|:.....::..||.|||
  Fly   334 ATMMKRLEREIKVLKDKLAEEERKNENQQKVEHLER--------QIKHDMHKIICGHSLSDK--- 387

  Fly   434 LMPPPTGQEPRQASSQNSTLMGIVEETEPKESSKVQQSMVAPTVPTTVRCQLFNTTISPISLRAS 498
                  ||:.|:.:                            ..||                 ||
  Fly   388 ------GQQKRRRT----------------------------WCPT-----------------AS 401

  Fly   499 SSQRELSGIQPMEETVVASPQQPCLRRSVRLASSMRSQNYGAIPKVMNL 547
            .|..||:.....|:.:...|:...|.:.|...:|...:.:..|||.:|:
  Fly   402 GSHLELAETGTTEDRIDQFPKVSHLPKPVFFHTSNAGKRWDNIPKTINI 450

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nod	NP_001285129.1	KISc	8..325	CDD:214526	110/338 (33%)
		KISc	8..318	CDD:276812	106/331 (32%)
		ComEA	540..648	CDD:224472	4/8 (50%)
cmet	NP_524993.3	KISc	8..328	CDD:214526	113/373 (30%)
		Motor_domain	8..321	CDD:277568	108/333 (32%)
		Smc	<680..1449	CDD:224117
		TMPIT	779..>867	CDD:285135
		Smc	1042..1910	CDD:224117
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45437927
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840