Protein Alignment nod and Kif14

DIOPT Version :10

• Sequence 1: NP_511125.2
• Gene: nod / 32107
• FlyBaseID: FBgn0002948
• Length: 666
• Species: Drosophila melanogaster
• Sequence 2: XP_006529793.2
• Gene: Kif14 / 381293
• MGIID: 1098226
• Length: 1717
• Species: Mus musculus
• Alignment Length: 829
• Identity: 209/829 - (25%)
• Similarity: 322/829 - (38%)
• Gaps: 219/829 - (26%)

  Fly     7 SAVRIAVREAPYRQFLGRREPS--------------VVQFPPWSDGKSLIVDQNEFHFDHAFPAT 57
            |.|.:|||..|:    .:||.:              .|:.|......|.|.|.:.:.||...|..
Mouse   392 SQVTVAVRVRPF----SKREKTEKASQVVFTNGEEITVEHPDMKQVYSFIYDVSFWSFDECHPGY 452

  Fly    58 ISQDEMYQALILPLVDKLLEGFQCTALAYGQTGTGKSYS-MGMTPPGEILPEHLGILPRALGDIF 121
            .||..:|:.|..||:|:..||:.....||||||:||||: ||       |.|..||:||...|:|
Mouse   453 ASQTTVYETLAAPLLDRAFEGYNTCLFAYGQTGSGKSYTMMG-------LNEEPGIIPRFCEDLF 510

  Fly   122 ERVTARQENNKDAIQVYASFIEIYNEKPFDL-------------LGSTPHMPMVAARCQRCTCLP 173
            .:: |:::.::.:..:..||.|:||||..||             |.:..| |:.....:..:...
Mouse   511 AQI-AKKQTSEVSYHLEMSFFEVYNEKIHDLLVCKGENGQRKQPLRAREH-PVSGPYVEGLSMNV 573

  Fly   174 LHSQADLHHILELGTRNRRVRPTNMNSNSSRSHAIVT-IHVKSKT---------HH--SRMNIVD 226
            :.|.:|:...||||.:.|....|.||..|||||::.| :..::||         |.  ||:|:||
Mouse   574 VSSYSDIQSWLELGNKQRATAATGMNDKSSRSHSVFTLVMTQTKTEVVEGEEHDHRITSRINLVD 638

  Fly   227 LAGSEGVRRTGHEGVARQEGVNINLGLLSINKVVMSM---AAGHTV-IPYRDSVLTTVLQASLTA 287
            |||||........|...:|||:||..||::.||:.::   |.|..| ||||:|.||.:|:.||..
Mouse   639 LAGSERCSTAHSSGQRLKEGVSINKSLLTLGKVISALSEQANGKRVFIPYRESTLTWLLKESLGG 703

  Fly   288 QSYLTFLACISPHQCDLSETLSTLRFGTSAKKL----RLNPMQVARQKQSLAA------------ 336
            .|....:|.:||...::.|||||||:.|.|:.:    ::|....|:..:.|.|
Mouse   704 NSKTAMIATVSPAASNIEETLSTLRYATQARLIVNIAKVNEDMNAKLIRELKAEIEKLKAAQRSN 768

  Fly   337 RTTHVFRQALC----TSTAIKSNAANHNSIVV-----------PKSKYSTTKPLSAVLHRTRSEL 386
            |.....|..||    ||..:|.:....:...:           .|.|...||.|        .:.
Mouse   769 RNIDPERYRLCRQEITSLRMKLHQQERDMAEIQRVWKEKFEQAEKRKLQETKEL--------QKA 825

  Fly   387 GMTPKAKKRARELLELEE----------------TT-----------LELSSIHIQDSSLSLLGF 424
            |:|.:.......|:.|.|                ||           ::||.:.|.|...::..|
Mouse   826 GVTFQMDNHLPNLVNLNEDPQLSEMLLYMVKEGVTTVGKHTPSSSHDIQLSGVLIADDHCTIRNF 890

  Fly   425 ----------------------------HSD-----SDKDRHLMPPPTGQEPRQASSQNSTLMGI 456
                                        |.|     .|.......|...|:.::.||:|:    :
Mouse   891 GGTVSIVPAGEAKTYVNGTHISEPTVLHHGDRVVLGGDHYFRFNHPVEVQKGKKLSSRNN----L 951

  Fly   457 VEETEPKESSKVQQSMVAPTVPTTVRCQLFNTTISPISLRASSSQRELSGIQPMEETV--VASPQ 519
            .....||:....:..::     |..|.:| ...|....|:|  .:..:.|||..:|..  ..|.|
Mouse   952 TTSEGPKDFEFAKNELL-----TAQRSRL-EAEIKDAQLKA--KEEMMQGIQIAKEMAQQELSSQ 1008

  Fly   520 QPCLRRSVR-LASSMRSQ----------NYGAIPKVMNLRRSTRLAGIREHATSVVVKN------ 567
            :....|.:: |.:.:|.:          |..|..|:..|.|:      ::|....|..|
Mouse  1009 KAVYERKIQALEAELREESQRKRLEELNNQKASHKIEELERA------KQHLEQEVYVNKRRLEM 1067

  Fly   568 ---------ETDAIPHLRSTVQKKRTRNVKPAPKAWM-----ANNTKCFLDLLNNGNVK---QLQ 615
                     |...|.|.| .::.......|.|.:..|     .|..|.|....|..::|   .:|
Mouse  1068 ETLATKQALEDHRIRHAR-ILEALEIEKQKIAEEVQMLQENRGNRDKTFTIQPNWNSMKLSTMIQ 1131

  Fly   616 EIPGIGP--KSAFSLALH-RSRLGCFENLFQVKSLPI-----WSGNKWE 656
            |...|..  |..:....| .|..|..:...:|::|.:     ||..|:|
Mouse  1132 EANAISDKFKKCYIFGRHDASDKGRSDTSVRVRNLQLGISTFWSLEKFE 1180

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nod	NP_511125.2	KISc	8..318	CDD:276812	121/353 (34%)
		ComEA	606..>645	CDD:441164	9/44 (20%)
Kif14	XP_006529793.2	KISc_KIF1A_KIF1B	392..743	CDD:276816	123/363 (34%)
		Kinesin_assoc	740..859	CDD:465047	21/126 (17%)
		FHA_KIF14	829..936	CDD:438759	13/106 (12%)
		SMC_prok_B	<937..>1109	CDD:274008	36/190 (19%)