Protein Alignment nod and kif1b

DIOPT Version :10

• Sequence 1: NP_511125.2
• Gene: nod / 32107
• FlyBaseID: FBgn0002948
• Length: 666
• Species: Drosophila melanogaster
• Sequence 2: XP_068072796.1
• Gene: kif1b / 369190
• ZFINID: ZDB-GENE-030820-1
• Length: 1927
• Species: Danio rerio
• Alignment Length: 783
• Identity: 181/783 - (23%)
• Similarity: 301/783 - (38%)
• Gaps: 230/783 - (29%)

  Fly     1 MEGAKLSAVRIAVREAPYR-QFLGRREPSVVQFPPWSDGKSLIV-------DQNEFHFDHAF--- 54
            |.||   :|::|||..|:. :..|:....::|.    .|.|..:       :...|.||:::
Zfish     1 MSGA---SVKVAVRVRPFNSRETGKESKCIIQM----QGNSTTILNPKNPKEPKTFSFDYSYWSH 58

  Fly    55 -----PATISQDEMYQALILPLVDKLLEGFQCTALAYGQTGTGKSYS-MGMTPPGEILPEHLGIL 113
                 |:..||:::|..:...::....||:.....||||||.||||: ||....|:     .||:
Zfish    59 TSPDDPSFASQNQVYNDIGKEMLQHAFEGYNVCIFAYGQTGAGKSYTMMGKQEEGQ-----EGII 118

  Fly   114 PRALGDIFERVTARQENNKDAI--QVYASFIEIYNEKPFDLLG-------STPHMPMVAARCQRC 169
            |:...::||::   .:||.:.|  .|..:::|||.|:..|||.       .....|::....:..
Zfish   119 PQLCEELFEKI---NDNNNEEISYSVEVAYMEIYCERVRDLLNPKNKGNLRVREHPLLGPYVEDL 180

  Fly   170 TCLPLHSQADLHHILELGTRNRRVRPTNMNSNSSRSHAIVTIHVKSKTHH----------SRMNI 224
            :.|.:.|..|:..:::.|.:.|.|..||||..||||||:.||....:.:.          |::::
Zfish   181 SKLAVTSYTDIADLMDAGNKARTVAATNMNETSSRSHAVFTIVFTQRKYDSETDLSTEKVSKISL 245

  Fly   225 VDLAGSEGVRRTGHEGVARQEGVNINLGLLSINKVVMSMAAGHT------------VIPYRDSVL 277
            |||||||....||.:|...:||.|||..|.::.||:.::|....            .||||||||
Zfish   246 VDLAGSERADSTGAKGTRLKEGANINKSLTTLGKVISALAEVDNCTSKSKKKKKTDFIPYRDSVL 310

  Fly   278 TTVLQASLTAQSYLTFLACISPHQCDLSETLSTLRFGTSAKKLRLNPM---------------QV 327
            |.:|:.:|...|....:|.:||...:..|||||||:...||:::.|.:               :|
Zfish   311 TWLLRENLGGNSRTAMVAALSPADINFDETLSTLRYADRAKQIKCNAVINEDPNAKLVRELKDEV 375

  Fly   328 ARQKQSLAARTTHVFRQAL------------CTSTAIKSNAANHNSIVVPKSKYSTTKPLSAVLH 380
            :|.|:.|.|       |.|            |..:..|.....||:    |.:|..........|
Zfish   376 SRLKELLRA-------QGLGDILDIEPMGDDCLGSGSKYLKDIHNN----KHRYLLASENQRPGH 429

  Fly   381 RTRSELGMTPKAKKRARELLELEETTLELSSIHIQDSSLSLLGFHSDSDKDRHLMPPPTGQEPRQ 445
            .:.:.:|.                    |::.....|..|..|..|.|.....:|..|.|:|..:
Zfish   430 FSTAPMGC--------------------LTASPSSGSLCSQAGLQSVSSIQERIMSTPGGEEAIE 474

  Fly   446 ASSQNSTLMGIVEETEPKESSKVQ------QSMVA----------------------PTVPTTVR 482
            ...::..::..:.||..::..|.:      ::::|                      |..||::.
Zfish   475 RLKESEKIIAELNETWEEKLRKTEAIRMEREALLAEMGVAIREDGGTLGVFSPKKFGPDRPTSLS 539

  Fly   483 -----------------CQL---FNTTISP------ISL----------------------RASS 499
                             |::   ||...||      ::|                      :|.:
Zfish   540 IEDFSVYSSNQLFVERPCEVYTDFNGVFSPKKTPHLVNLNEDPLMSECLLYYIKDGITRVGQADA 604

  Fly   500 SQRE---LSGIQPMEETVVASPQQPCLRRSVRLASS---------MRSQNYGAIPKVMNLRRSTR 552
            .:|:   |||....||        .|:.||.|.|:.         ..|:.|      :|.:|...
Zfish   605 ERRQDIVLSGAHIKEE--------HCIFRSERNANGHVIVTLEPCEGSETY------VNGKRVNS 655

  Fly   553 LAGIREHATSVVVKNETDAIPH---LRSTVQKKRTRNVKPAPKAWMANNTKCFLDLLNNGNVKQL 614
            ...:|.....::.||......|   .|:..:|..:......|..|    |....:||....:...
Zfish   656 AVQLRSGNRIIMGKNHVFRFNHPEQARAEREKTPSAETPVEPVDW----TFAQRELLEKQGIDMK 716

  Fly   615 QEI 617
            ||:
Zfish   717 QEM 719

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nod	NP_511125.2	KISc	8..318	CDD:276812	108/357 (30%)
		ComEA	606..>645	CDD:441164	3/12 (25%)
kif1b	XP_068072796.1	KISc_KIF1A_KIF1B	4..360	CDD:276816	112/370 (30%)
		Kinesin_assoc	357..596	CDD:465047	38/269 (14%)
		FHA_KIF1B	571..680	CDD:438779	21/122 (17%)
		GBP_C	<680..754	CDD:293879	9/44 (20%)
		KIF1B	889..937	CDD:463574
		KIF1B	<999..1021	CDD:463574
		DUF3694	1373..1529	CDD:463599
		PH_KIFIA_KIFIB	1808..1910	CDD:269939