DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nod and Cenpe

DIOPT Version :9

Sequence 1:	NP_001285129.1	Gene:	nod / 32107	FlyBaseID:	FBgn0002948	Length:	666	Species:	Drosophila melanogaster
Sequence 2:	XP_038959788.1	Gene:	Cenpe / 362044	RGDID:	1307115	Length:	2456	Species:	Rattus norvegicus

Alignment Length:	701	Identity:	160/701 - (22%)
Similarity:	275/701 - (39%)	Gaps:	208/701 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 AKLSAVRIAVREAPYRQFLGRREPSVVQFPP--WSDGKSLIVDQN---EFHFDHAFPATISQDEM 63
            |:.:||.:.||..|    |..||..:.:...  |...|:.|...:   .|.||..|.:..:...:
  Rat     2 AEEAAVAVCVRVRP----LNSREEELGEASHIYWKTDKNAIYQSDGGKSFQFDRVFHSNETTKNV 62

  Fly    64 YQALILPLVDKLLEGFQCTALAYGQTGTGKSYSMGMTPPGEILPEHLGILPRALGDIFERVTARQ 128
            |:.:.:|::...::|:..|..|||||.:||:::|..:      .:.||::|||:.|||:|:....
  Rat    63 YEEIAVPIISSAIQGYNGTIFAYGQTASGKTHTMMGS------EDCLGVIPRAIHDIFQRIKKFP 121

  Fly   129 ENNKDAIQVYASFIEIYNEKPFDLLGSTPHMPMVAARCQRCTCLPLHSQADLH---HILEL---- 186
            |..   ..:..|::|||||...|||            |......||..:.|::   ::.:|
  Rat   122 ERE---FLLRVSYMEIYNETITDLL------------CNTQKVKPLIIREDINRNVYVADLTEEV 171

  Fly   187 -------------GTRNRRVRPTNMNSNSSRSHAIVTIHVKSKTHH-----------SRMNIVDL 227
                         |.:||....|.||..|||||.|..:.::|:...           |.:|:|||
  Rat   172 VYTAEMALKWLATGEKNRHYGITKMNQRSSRSHTIFRMILESREKAESSNCDGSIKVSHLNLVDL 236

  Fly   228 AGSEGVRRTGHEGVARQEGVNINLGLLSINKVVMSMAAGHT--VIPYRDSVLTTVLQASLTAQSY 290
            ||||...:||.||:..:||..||..||.:.:|:..::.|..  .|.||||.||.:||.||...:.
  Rat   237 AGSERAAQTGAEGMRLKEGCYINRNLLILGQVIKKLSDGQVGGFINYRDSKLTRILQNSLGGNAK 301

  Fly   291 LTFLACISPHQCDLSETLSTLRFGTSAKKLRLNPMQVARQKQSLAARTTHVFRQALCTSTAIKSN 355
            ...:..|:|  ..|.|||:||:|.::||.::..|.                            .|
  Rat   302 TRIICTITP--ASLDETLTTLQFASTAKYMKNTPY----------------------------VN 336

  Fly   356 AANHNSIVVPKSKYSTTKPLSAVLHRTRSELGMTPKAKKRARELLELEETTLELSSIHIQDSSLS 420
            ..:::               .|:|.|.|.|:....|         :|||...:..:..|:...|:
  Rat   337 EVSND---------------EALLKRYRREIVDLKK---------QLEEVNTKTRAQEIEKDQLA 377

  Fly   421 LLGFHSDSDKDRHLMPPPTGQEPRQASSQN-------STLMGIVEETE-------------PKES 465
            .|    ..:||  |:     |:.:....||       |:.:.:.:|.|             .|:|
  Rat   378 QL----LDEKD--LL-----QKVQDEKIQNLKRMLVTSSSIALQQELEIKKKRRVTWCFGKMKDS 431

  Fly   466 SKVQQSMVAPTVPTTVR-----------------------CQLFNTTISPIS----------LRA 497
            :.|::..:...:.|..|                       .::|:.|:.|::          |..
  Rat   432 NYVKEFKIPTNITTRTRKTSVTPLRENSLMKLGESALSWESEVFDNTLEPLAEAEWSSATALLSE 496

  Fly   498 SSSQRELSGIQPMEETVVASPQQPCLRR-----SVRLAS-------------SMRSQNYGAIPKV 544
            .:.:.||:.:......:|...:|  |||     .::|..             ..:.|....:.:|
  Rat   497 ENLESELTSLNTQYNNLVLDYEQ--LRRENEDLKLKLKEKNELEEFEFLEQREEKDQELQLMHEV 559

  Fly   545 MNLRRSTRLA-----GIREHATSVV--VKNETDAIPHLRSTVQKKRTRNVK 588
            .||:...:.|     .:....:|.|  :|.:.|.|..|:..:..:::...|
  Rat   560 SNLKNLIKHAEEYNQDLENELSSKVELLKEKEDQIKELQRYIDAQKSETTK 610

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nod	NP_001285129.1	KISc	8..325	CDD:214526	107/354 (30%)
		KISc	8..318	CDD:276812	105/347 (30%)
		ComEA	540..648	CDD:224472	11/56 (20%)
Cenpe	XP_038959788.1	KISc_CENP_E	6..329	CDD:276825	107/349 (31%)
		Smc	<334..1057	CDD:224117	51/342 (15%)
		Smc	787..1603	CDD:224117
		Smc	1320..2167	CDD:224117
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000