DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nod and Klp31E

DIOPT Version :9

Sequence 1:	NP_001285129.1	Gene:	nod / 32107	FlyBaseID:	FBgn0002948	Length:	666	Species:	Drosophila melanogaster
Sequence 2:	NP_001162935.1	Gene:	Klp31E / 34422	FlyBaseID:	FBgn0032243	Length:	1048	Species:	Drosophila melanogaster

Alignment Length:	708	Identity:	175/708 - (24%)
Similarity:	298/708 - (42%)	Gaps:	148/708 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 KLSAVRIAVREAPYRQ-------------FLGRREPSVVQFPPWSDGKSLIVDQNEFHFDHAFPA 56
            |.|:||:|||..|...             .||  ||.:           .:.....|.||:.|..
  Fly    10 KDSSVRVAVRIRPQNSRELIDMCRICTTVTLG--EPQI-----------FLGSDKAFTFDYVFDT 61

  Fly    57 TISQDEMYQALILPLVDKLLEGFQCTALAYGQTGTGKSYSMGMTPPGEILPE---HLGILPRALG 118
            ..:|.::|...:..|||..|.|:..|.|||||||:||:|:||.....|....   .|||:|||:.
  Fly    62 NSNQCDIYSDCVEKLVDSTLHGYNATVLAYGQTGSGKTYTMGTGFDHESESSDSVQLGIIPRAVR 126

  Fly   119 DIF---ERVTARQENNKDA------IQVYASFIEIYNEKPFDLL-------------GSTPHMPM 161
            .||   |::.....:...|      ..:...:||:|||..||||             .::..:.:
  Fly   127 HIFSGIEQLEGSSTSEHPAAGGSPQFSLAVQYIELYNEDIFDLLDPFNKNSNFKIHEDASGQITI 191

  Fly   162 VAARCQRCTCLPLHSQADLHHILELGTRNRRVRPTNMNSNSSRSHAIVTIHVKS----------- 215
            ..|..:     |::...|....|:.|...|....|.||..||||||:.||.|:.
  Fly   192 SGASIK-----PIYQPHDALKYLQQGALARTTASTKMNDQSSRSHALFTIFVRRQRLLTPSDNVP 251

  Fly   216 ----KTHHSRMNIVDLAGSEGVRRTGHEGVARQEGVNINLGLLSINKVVMSMA-----AGHTVIP 271
                :|..|:.:.|||||||.::||...|...:||::||.|||::...:.::.     |.|  :|
  Fly   252 DNDLETLTSKFHFVDLAGSERLKRTQATGERAREGISINCGLLALGNCISALGDKSKRALH--VP 314

  Fly   272 YRDSVLTTVLQASLTAQSYLTFLACISPHQCDLSETLSTLRFGTSAK----KLRLNPMQ----VA 328
            ||||.||.:||.||...|....:||:||...|..|||:||::...|:    |:::|..|    ::
  Fly   315 YRDSKLTRLLQDSLGGNSQTLMIACVSPSDRDFMETLNTLKYANRARNIKNKVKINQDQSSRTIS 379

  Fly   329 RQKQSLAARTTHV--FRQAL----CTSTAIKSNAANHNSIVVP---------KSKYSTTKPLSAV 378
            :.::.:||....:  ::|..    |......|:..|.|.:::.         ||..||...|:..
  Fly   380 QLRREIAALQLELLEYKQGKLIVDCEGNTTISDTFNENKLLLSEIKRLQQRLKSLQSTIATLTQR 444

  Fly   379 LHRTRSELGM----------TPKAKKRARELLELEE-------------------TTLELSSIHI 414
            ....::.|.:          ...||...:.:||:||                   ||...::..:
  Fly   445 NADLKTNLDLNKWTSDDNSDVEIAKVVGQYMLEIEELQTKLIESEEHRKQMEIKATTSPRNAKPV 509

  Fly   415 QDSSLSLLGFHSDSDKDRHL-----MPPPTGQ----EPRQASSQNSTLMGIVEETEPKESS-KVQ 469
            .||.: :.....|.:::|.|     :|....|    |..:.:|.:|....:|::.|..::. :::
  Fly   510 YDSDI-ITKAKKDLERERELLMSRSLPGIQNQNVSSEETEVASSDSEAEEVVKDLEAIDNDIEMR 573

  Fly   470 QSMVAPTVPTTVRCQLFNT----TISPISLRASSSQRELSGIQPMEETVVASPQQPCLRRSVRLA 530
            ..::.....|..|.:...|    .:|.:..:..::|:|...:.....|.|::|.:..|::.....
  Fly   574 TKLIEQLELTNSRYEQMRTHYEEKLSVLYCKIENTQKERDDVLANMTTSVSTPSKDSLKKVKTDY 638

  Fly   531 SSMRSQNYGAIPKVMNLRRS--TRLAGIREHATSV-VVKNETDAIPHLRSTVQKKRTR 585
            .|..|.....|.|:.|.:|.  .....::.|...: .::||.:.:...:..:.||.::
  Fly   639 ESKISHMQTEIRKLQNAQREHIRSKQQLKSHEVRIGTLRNELNELKFAKVKLMKKMSQ 696

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nod	NP_001285129.1	KISc	8..325	CDD:214526	118/378 (31%)
		KISc	8..318	CDD:276812	115/367 (31%)
		ComEA	540..648	CDD:224472	9/49 (18%)
Klp31E	NP_001162935.1	KISc_KIF4	12..364	CDD:276823	117/371 (32%)
		KISc	13..370	CDD:214526	117/376 (31%)
		KASH_CCD	409..589	CDD:291334	31/180 (17%)
		RasGAP	<685..750	CDD:295371	2/12 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45437895
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0244
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24115
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.930