DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nod and Klp10A

DIOPT Version :9

Sequence 1:	NP_001285129.1	Gene:	nod / 32107	FlyBaseID:	FBgn0002948	Length:	666	Species:	Drosophila melanogaster
Sequence 2:	NP_001285109.1	Gene:	Klp10A / 32049	FlyBaseID:	FBgn0030268	Length:	805	Species:	Drosophila melanogaster

Alignment Length:	512	Identity:	133/512 - (25%)
Similarity:	226/512 - (44%)	Gaps:	81/512 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 VRIAVREAPY-RQFLGRREPSVVQFPPWSDGKSLIV--------------DQNEFHFDHAFPATI 58
            :.:.||:.|. |:.:.|:|..|:..|    .|.:::              :.::|.||:||..|.
  Fly   279 ITVCVRKRPISRKEVNRKEIDVISVP----RKDMLIVHEPRSKVDLTKFLENHKFRFDYAFNDTC 339

  Fly    59 SQDEMYQALILPLVDKLLEGFQCTALAYGQTGTGKSYSMGMTPPGEILPEHLGILPRALGDIFER 123
            ....:|:....|||..:.||...|..||||||:||:::||....|::.....||...|..|:|..
  Fly   340 DNAMVYKYTAKPLVKTIFEGGMATCFAYGQTGSGKTHTMGGEFNGKVQDCKNGIYAMAAKDVFVT 404

  Fly   124 VTARQENNKDAIQVYASFIEIYNEKPFDLLGSTPHMPMVAARCQRCTCLPLHSQA--DLHHILEL 186
            :...:....:.: |.|||.|||:.|.||||.....:.::....|:...:.|..:.  .:..:|:|
  Fly   405 LNMPRYRAMNLV-VSASFFEIYSGKVFDLLSDKQKLRVLEDGKQQVQVVGLTEKVVDGVEEVLKL 468

  Fly   187 ---GTRNRRVRPTNMNSNSSRSHAIVTIHVK---SKTHHSRMNIVDLAGSE-GVRRTGHEGVARQ 244
               |...|....|:.|||||||||:..|.::   |...|.:.:.:||||:| ||..:..:...|.
  Fly   469 IQHGNAARTSGQTSANSNSSRSHAVFQIVLRPQGSTKIHGKFSFIDLAGNERGVDTSSADRQTRM 533

  Fly   245 EGVNINLGLLSINKVVMSMAAGHTVIPYRDSVLTTVLQASLTAQSYLT-FLACISPHQCDLSETL 308
            ||..||..||::.:.:.::......:|:|.|.||.||:.|...:...| .:|.|||.......||
  Fly   534 EGAEINKSLLALKECIRALGKQSAHLPFRVSKLTQVLRDSFIGEKSKTCMIAMISPGLSSCEHTL 598

  Fly   309 STLRFGTSAKKLRL------------NPMQVARQKQSLAARTTHVFRQALCTST---AIKSN--- 355
            :|||:....|:|.:            .|:::...::.......|.....|..::   |.:||
  Fly   599 NTLRYADRVKELVVKDIVEVCPGGDTEPIEITDDEEEEELNMVHPHSHQLHPNSHAPASQSNNQR 663

  Fly   356 --AANHNSIVVPKSKYSTTK----------PLSAVL-HRTRSELGMTPKAKKRARELLELEETTL 407
              |::|:..|:..:..:..|          .||::. |....||.:..:|   ..:|.:.||..:
  Fly   664 APASHHSGAVIHNNNNNNNKNGNAGNMDLAMLSSLSEHEMSDELIVQHQA---IDDLQQTEEMVV 725

  Fly   408 E--------LSSIHIQDSSLSLLGFHSDSDKDRHLMPPPTGQEPRQASSQNSTLMGI 456
            |        |.:...:..:|..|..:.|.|:|.:.         ::..|..|.|:.|
  Fly   726 EYHRTVNATLETFLAESKALYNLTNYVDYDQDSYC---------KRGESMFSQLLDI 773

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nod	NP_001285129.1	KISc	8..325	CDD:214526	103/352 (29%)
		KISc	8..318	CDD:276812	101/333 (30%)
		ComEA	540..648	CDD:224472
Klp10A	NP_001285109.1	KISc_KIF2_like	278..608	CDD:276818	101/333 (30%)
Klp10A	NP_001285109.1	Kinesin	284..609	CDD:278646	100/329 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45437802
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24115
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.030