DRSC/TRiP Functional Genomics Resources

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Protein Alignment nod and Klp3A

DIOPT Version :10

Sequence 1:NP_511125.2 Gene:nod / 32107 FlyBaseID:FBgn0002948 Length:666 Species:Drosophila melanogaster
Sequence 2:NP_525053.1 Gene:Klp3A / 31240 FlyBaseID:FBgn0011606 Length:1212 Species:Drosophila melanogaster


Alignment Length:715 Identity:184/715 - (25%)
Similarity:298/715 - (41%) Gaps:152/715 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly     7 SAVRIAVREAPYRQF-LGRREPSVVQFPPWSDG-KSLIVDQNE-FHFDHAFPATISQDEMYQALI 68
            |.|.:|:|..|..|. |.|.....|:..  :|| ..:.|::|| :.:::.|....||.::::..:
  Fly     7 SCVAVALRVRPLVQSELDRGCRIAVERS--ADGAPQVTVNRNESYTYNYVFDIDDSQKDLFETCV 69

  Fly    69 LPLVDKLLEGFQCTALAYGQTGTGKSYSMGMTPPGEILPEHLGILPRALGDIFERVTARQENNKD 133
            ...|.|||.|:..|.|||||||:||:|:||....| :|.:|:|::|||:.|||..:...|...:.
  Fly    70 QAKVKKLLNGYNVTILAYGQTGSGKTYTMGTAFNG-VLDDHVGVIPRAVHDIFTAIAEMQSEFRF 133

  Fly   134 AIQVYASFIEIYNEKPFDLLGSTPH---------------MP----MVAARCQRCTCLPLHSQAD 179
            |  |..||:|:|.|:.:||..|...               ||    :|....|:.|         
  Fly   134 A--VTCSFVELYQEQFYDLFSSKTRDKATVDIREVKNRIIMPGLTELVVTSAQQVT--------- 187

  Fly   180 LHHILELGTRNRRVRPTNMNSNSSRSHAIVTIHV-------KSKTHHSRMNIVDLAGSEGVRRTG 237
             .|::. |:..|.|..|.||..|||||||.|:.:       |.....||.|:|||||||...:|.
  Fly   188 -DHLIR-GSAGRAVAATAMNETSSRSHAIFTLTLVATKLDGKQSVTTSRFNLVDLAGSERCSKTL 250

  Fly   238 HEGVARQEGVNINLGLLSINKVVMSMAAGHTV--IPYRDSVLTTVLQASLTAQSYLTFLACISPH 300
            ..|...:||||||.|||::..|:.::.:|...  ||||.|.||.:||.||...|....:||:||.
  Fly   251 ASGDRFKEGVNINKGLLALGNVINALGSGQAAGYIPYRQSKLTRLLQDSLGGNSITLMIACVSPA 315

  Fly   301 QCDLSETLSTLRFGTSAKKLRLNPM--------QVARQKQSLAARTTHVFRQALCTSTAIKSNAA 357
            ..:::|||||||:...|.:::..|:        :|...|..:......:......:|:.|.:..|
  Fly   316 DYNVAETLSTLRYADRALQIKNKPVVNLDPHAAEVNMLKDVIQKLRVELLSGGKMSSSLISAVGA 380

  Fly   358 NHNSIVVPKSKYSTTKPLSAVLHRTRSELGMTPKAKKRARELLELEETTLELSS----IHIQDSS 418
            .....:..:...:.:...:|.:.|.:.::.......::.::  ||.::.|:|:.    .||.:.:
  Fly   381 AGLGAIPCEESLAGSMANAAEIQRLKEQVRTLQDRNRKLQQ--ELHQSLLDLTEKEMRAHIAEQA 443

  Fly   419 LSLLGFHSDSDKDRHLMPPPTGQEPRQASSQNSTLMGIVEETEPKESSKVQQSMVAPTVPTTVRC 483
            ...|..|....|::.       .:..||...|....|   :.|.::                   
  Fly   444 HDKLRSHVSELKNKL-------DQREQAQFGNENTNG---DNEMRD------------------- 479

  Fly   484 QLFNTTISPISLRASSSQRELSGIQPMEETVVASPQQPCLRRS-----------VRLASSMRSQN 537
              |:..::.:.:....:|.||       |:.....:|....||           |.......|:.
  Fly   480 --FSLLVNRVHVELQRTQEEL-------ESQGHESRQRLSSRSHTEGGESGGDEVHEMLHSHSEE 535

  Fly   538 YGAIPKVMN----LRRSTRLAGIREHATSVVVKN-----ETDAIPHLRSTVQK------------ 581
            |  ..|.||    ||...|...:::.....:::|     ..|....||...||            
  Fly   536 Y--TNKQMNFAGELRNINRQLDLKQELHERIMRNFSRLDSDDEDVKLRLCNQKIDDLEAERRDLM 598

  Fly   582 KRTRNVKPAP-KAWMANNTKCFLDLLNNGNVKQLQEIPGIGPKSAFSLALHRSRLGCFENLFQVK 645
            .:.||:|... .|.:|...:..|.||.       |||..:           |.:|....||.:::
  Fly   599 DQLRNIKSKDISAKLAEERRKRLQLLE-------QEISDL-----------RRKLITQANLLKIR 645

  Fly   646  645
              Fly   646  645

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nodNP_511125.2 KISc 8..318 CDD:276812 122/340 (36%)
ComEA 606..>645 CDD:441164 8/38 (21%)
Klp3ANP_525053.1 KISc_KIF4 7..336 CDD:276823 124/344 (36%)
Smc <453..>985 CDD:440809 44/251 (18%)
Metallothio <1071..1115 CDD:395080
Blue background indicates that the domain is not in the aligned region.

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