Protein Alignment nod and Kif18b

DIOPT Version :10

• Sequence 1: NP_511125.2
• Gene: nod / 32107
• FlyBaseID: FBgn0002948
• Length: 666
• Species: Drosophila melanogaster
• Sequence 2: NP_001427099.1
• Gene: Kif18b / 303575
• RGDID: 1310360
• Length: 841
• Species: Rattus norvegicus
• Alignment Length: 742
• Identity: 196/742 - (26%)
• Similarity: 309/742 - (41%)
• Gaps: 190/742 - (25%)

  Fly     7 SAVRIAVREAP--YRQFLGRREPSVVQ-----------------FP--PWS--------DGKSLI 42
            |.||:.||..|  .::...:|.| |:|                 ||  .||        .||.|
  Rat     8 SVVRVVVRVRPPTPKELESQRRP-VIQVVDERMLVFDPEECDGGFPGLKWSGSLSGPKKKGKDL- 70

  Fly    43 VDQNEFHFDHAFPATISQDEMYQALILPLVDKLLEGFQCTALAYGQTGTGKSYSMGMTPPGEILP 107
                .|.||..|....:|.:::|.....::|..|:|:.|:..|||.||.||:::| :...|:  |
  Rat    71 ----TFVFDRVFSEVATQQDVFQHTTHNILDSFLQGYNCSVFAYGATGAGKTHTM-LGREGD--P 128

  Fly   108 EHLGILPRALGDIFERVTARQENNKDAIQVYASFIEIYNEKPFDLLGSTPHMPM-VAARCQRCTC 171
               ||:.....:::.|:.|.||..:  .:|..|::|:|||:.:|||  .|..|: :.....:...
  Rat   129 ---GIMYLTTMELYRRLEACQEEKQ--FEVLISYLEVYNEQIYDLL--EPKGPLTIREDPDKGVV 186

  Fly   172 LP---LHSQADLHHILELGTR---NRRVRPTNMNSNSSRSHAIVTIHVKSK---------THHSR 221
            :|   .|..|....:||:.||   :|...||:.|:.|||||||..|.||.:         ...::
  Rat   187 VPGLSFHQPASAQQLLEMLTRGNCSRTQHPTDANATSSRSHAIFQIFVKQQDRVPGLTQALRVAK 251

  Fly   222 MNIVDLAGSEGVRRTGHEGVARQEGVNINLGLLSINKVVMSMA-----AGHTVIPYRDSVLTTVL 281
            |:::||||||....|..:|...:||.|||..||::..|:.::|     ..|  :|||||.||.:|
  Rat   252 MSLIDLAGSERASSTHAKGERLREGANINRSLLALINVLNALADAKGRKSH--VPYRDSKLTRLL 314

  Fly   282 QASLTAQSYLTFLACISPHQCDLSETLSTLRFGTSAKKLRLNPMQVARQKQSLAARTTHVFRQAL 346
            :.|:........:|.:||......:|.:||::...||::||
  Rat   315 KDSIGGNCRTVMIAAVSPSSLTYEDTYNTLKYADRAKEIRL------------------------ 355

  Fly   347 CTSTAIKSNAANHNSIVVPKSKYST-TKPLSAVLHRTRSELGMTPKAKKRARELLELEETTL--- 407
                .:|||..:.:..:   |:|:| .:.|.|.:...|.:| .|.:|..:|.:....:...|
  Rat   356 ----TLKSNVISLDHHI---SQYATICQQLQAEVAALREKL-QTYEAGAQALQQRSPQPPKLSIP 412

  Fly   408 -ELSSIHIQ--DSSLSLL-GFHS--DSDKDRHLMPPPTGQEPRQASSQNSTLMGIVEETEPKESS 466
             .|||..:|  .||.|.. .||:  |:.::..|.....||             |.|||..|::..
  Rat   413 QNLSSSPLQPGHSSQSCAPEFHAKYDAPQEESLGTDSQGQ-------------GTVEENAPEQEQ 464

  Fly   467 KVQQ-----SMVAPTVP----TTVRCQLFNTTISPISLRASSS-----------QRELSGIQP-- 509
            ..|.     .|..|.:|    .||:.:......|...|.|..|           ||:.|.:|.
  Rat   465 PPQDKQFPTQMPEPNLPGSPCPTVQAKQGMNQHSLQRLDAEHSKQLALRVLRLAQRQYSLLQAAN 529

  Fly   510 -----------------MEETV---VASPQQPCLRRSVRLASSMRSQNYGAIPKVMNLR-----R 549
                             :||::   ..||:.|.|.|.:.||..:.|:: ...|..::||     .
  Rat   530 LLTPDMISEFETLQQLVLEESMEHGAESPRSPGLARGIPLAQELCSES-SECPLSLSLRPACSQE 593

  Fly   550 STRLAG--IREHATSVVVKNETDAIP----------HLRSTVQKKRTRNVK-----PAPKAWMAN 597
            |:|..|  .|..|..:.....|..||          ..:.|.:|||..|::     |||...|..
  Rat   594 SSRYCGPVTRTMAKQLSGLTHTLGIPLAPDCTSDKTSQKPTKEKKRKLNLEEPGSLPAPSVEMKR 658

  Fly   598 NTKCFLDLLNNGNVKQLQEIPGIGPKS 624
            ..:.||..|..|::.::|  |...|::
  Rat   659 QRQSFLPCLRRGSLPKIQ--PSSEPRT 683

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nod	NP_511125.2	KISc	8..318	CDD:276812	108/359 (30%)
		ComEA	606..>645	CDD:441164	5/19 (26%)
Kif18b	NP_001427099.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	396..496		26/112 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	617..700		18/69 (26%)
		Nuclear localization signal. /evidence=ECO:0000250	633..641		4/7 (57%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	777..803