DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nod and Kif21b

DIOPT Version :9

Sequence 1:	NP_001285129.1	Gene:	nod / 32107	FlyBaseID:	FBgn0002948	Length:	666	Species:	Drosophila melanogaster
Sequence 2:	XP_006249915.1	Gene:	Kif21b / 289397	RGDID:	1306206	Length:	1635	Species:	Rattus norvegicus

Alignment Length:	628	Identity:	170/628 - (27%)
Similarity:	262/628 - (41%)	Gaps:	151/628 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MEGAKLSAVRIAVREAPYRQFLGRRE-------PSVVQFPPWSDGKSLIVDQNEFHFDHAFPATI 58
            |.|.....|::|||..|.   |.:.:       .||....|    :.|:.....|.:|..|....
  Rat     1 MAGQGDCCVKVAVRIRPQ---LSKEKIEGCHICTSVTPGEP----QVLLGKDKAFTYDFVFDLDT 58

  Fly    59 SQDEMYQALILPLVDKLLEGFQCTALAYGQTGTGKSYSMGMTPPGEILPEHLGILPRALGDIFER 123
            .|:::|...:..|::...||:..|.|||||||.||:|:||.........|..||:|||:..:|..
  Rat    59 WQEQIYSTCVSKLIEGCFEGYNATVLAYGQTGAGKTYTMGTGFDTVTSEEEQGIIPRAIAHLFRG 123

  Fly   124 VTARQENNKD------AIQVYASFIEIYNEKPFDLLGST--PHMPMVAARCQR------------ 168
            :..|:...::      ..:|.|.|:|:|||:..||..||  |.     ||.:|
  Rat   124 IDERKRRAQEQGVTGPEFKVSAQFLELYNEEILDLFDSTRDPD-----ARHRRSNIKIHEDANGG 183

  Fly   169 -----CTCLPLHSQADLHHILELGTRNRRVRPTNMNSNSSRSHAIVTIHV--------------- 213
                 .|...::||.:|...|:.|..:|....|.||..|||||||.|||:
  Rat   184 IYTTGVTSRLINSQEELIQCLKQGALSRTTASTQMNVQSSRSHAIFTIHLCQMRVCAQPDLVNET 248

  Fly   214 -------------KSKTHHSRMNIVDLAGSEGVRRTGHEGVARQEGVNINLGLLSINKVV----- 260
                         :.:|..::.:.|||||||.::|||..|...:||::||.|||::..|:
  Rat   249 VTGLPDGTAPTGTEYETLTAKFHFVDLAGSERLKRTGATGERAKEGISINCGLLALGNVISALGD 313

  Fly   261 MSMAAGHTVIPYRDSVLTTVLQASLTAQSYLTFLACISPHQCDLSETLSTLRFGTSAKKLRLNPM 325
            .|....|  :|||||.||.:||.||...|....:||:||...|..|||:||::...|:.:: |.:
  Rat   314 QSKKVVH--VPYRDSKLTRLLQDSLGGNSQTIMIACVSPSDRDFMETLNTLKYANRARNIK-NKV 375

  Fly   326 QVARQK--QSLAARTTHVFRQAL------CTSTAIKSNAANHNSIVVPKSKYSTTKPLSAVLHRT 382
            .|.:.|  |.::|....:.|..:      .....|..:.|         ..||.....:|:|.:.
  Rat   376 VVNQDKTSQQISALRAEIARLQMELMEYKAGKRVIGEDGA---------EGYSDLFRENAMLQKE 431

  Fly   383 RSELGMTPKAKKRARELLELEETTLELSSIHIQDSSLSLLGFHSDSDKDRHLMPPPTGQEPRQAS 447
            ...|.:..||.:.|.:.:....|  :|.|   |:::| ||....|            |.|...|.
  Rat   432 NGALRLRVKAMQEAIDAINNRVT--QLMS---QEANL-LLAKAGD------------GNEAIGAL 478

  Fly   448 SQNSTLMGIVEETEPK--ESSKVQQSMVAPTVPTTVRCQLFNTTISPISLRAS-----------S 499
            .||  .:..:||...|  ||..:.:|:.......:.|        :|.||.||           |
  Rat   479 IQN--YIREIEELRTKLLESEAMNESLRRSLSRASAR--------NPYSLGASPAGPAFGGSPAS 533

  Fly   500 SQRELSGI-----QPME--------ETVVASPQQPCLRRSVRL 529
            |..:.|.:     |.:|        :...:||::...::..:|
  Rat   534 SMEDASEVIRRAKQDLERLKKKEVRQRRKSSPEKEAFKKRAKL 576

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nod	NP_001285129.1	KISc	8..325	CDD:214526	120/381 (31%)
		KISc	8..318	CDD:276812	118/374 (32%)
		ComEA	540..648	CDD:224472
Kif21b	XP_006249915.1	KISc_KIF4	7..372	CDD:276823	119/378 (31%)
		KISc	9..378	CDD:214526	120/383 (31%)
		PKK	657..791	CDD:289257
		JAKMIP_CC3	675..803	CDD:292653
		Prefoldin	961..1097	CDD:298833
		WD40	1303..1611	CDD:238121
		WD40	1304..>1612	CDD:225201
		WD40 repeat	1310..1344	CDD:293791
		WD40 repeat	1349..1385	CDD:293791
		WD40 repeat	1405..1448	CDD:293791
		WD40 repeat	1454..1498	CDD:293791
		WD40 repeat	1507..1539	CDD:293791
		WD40 repeat	1546..1570	CDD:293791
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0244
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900