DRSC/TRiP Functional Genomics Resources

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Protein Alignment nod and KIF4B

DIOPT Version :10

Sequence 1:NP_511125.2 Gene:nod / 32107 FlyBaseID:FBgn0002948 Length:666 Species:Drosophila melanogaster
Sequence 2:NP_001092763.1 Gene:KIF4B / 285643 HGNCID:6322 Length:1234 Species:Homo sapiens


Alignment Length:727 Identity:176/727 - (24%)
Similarity:294/727 - (40%) Gaps:185/727 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 EGAKLSAVRIAVREAPYRQFLGRREPS-----VVQFPPWSDGKSLIV--DQNEFHFDHAFPATIS 59
            |..|...||:|:|..|    |..:|.|     .:.|.|   |::.:|  ....|.:|..|.....
Human     3 EEVKGIPVRVALRCRP----LVPKEISEGCQMCLSFVP---GETQVVVGTDKSFTYDFVFDPCTE 60

  Fly    60 QDEMYQALILPLVDKLLEGFQCTALAYGQTGTGKSYSMG--MTPPGEILPEHLGILPRALGDIFE 122
            |:|::...:.||:..:.:|:..|.|||||||:||:||||  .|...|..|. :||:||.:..:|:
Human    61 QEEVFNKAVAPLIKGIFKGYNATVLAYGQTGSGKTYSMGGAYTAEQENEPT-VGIIPRVIQLLFK 124

  Fly   123 RVTARQENNKDAIQVYASFIEIYNEKPFDLL----------------------GSTPHMPMVAAR 165
            .:..:.:..   ..:..|::|||||:..|||                      |.|....:||..
Human   125 EIDKKSDFE---FTLKVSYLEIYNEEILDLLCPSREKAQINIREDPKEGIKIVGLTEKTVLVALD 186

  Fly   166 CQRCTCLPLHSQADLHHILELGTRNRRVRPTNMNSNSSRSHAIVTIHV-------KSKTHHSRMN 223
            ...|              ||.|..:|.|..|.|||.|||||||.||.:       |:.:..|:::
Human   187 TVSC--------------LEQGNNSRTVASTAMNSQSSRSHAIFTISIEQRKKSDKNCSFRSKLH 237

  Fly   224 IVDLAGSEGVRRTGHEGVARQEGVNINLGLLSINKVVMSMAAGH--TVIPYRDSVLTTVLQASLT 286
            :|||||||..::|..||...:||:|||.|||.:..|:.::....  :.:|||||.||.:||.||.
Human   238 LVDLAGSERQKKTKAEGDRLKEGININRGLLCLGNVISALGDDKKGSFVPYRDSKLTRLLQDSLG 302

  Fly   287 AQSYLTFLACISPHQCDLSETLSTLRFGTSAKKLRLNPM-------------------------- 325
            ..|:...:||:||...:|.|||||||:...|:|::..|:                          
Human   303 GNSHTLMIACVSPADSNLEETLSTLRYADRARKIKNKPIVNIDPHTAELNHLKQQVQQLQVLLLQ 367

  Fly   326 -------------------QVARQKQSLAARTTHVFRQALCTSTAIKSNAANHNSIVVPKSKYST 371
                               .:..:.|||......:.|   |.|.|....|.....|::       
Human   368 AHGGTLPGSINAEPSENLQSLMEKNQSLVEENEKLSR---CLSKAAGQTAQMLERIIL------- 422

  Fly   372 TKPLSAVLHRTRSELGMTPKAKKRARELLE-LEETTLELSSIHIQDSSLSLLGFHSDSDKDRHLM 435
            |:.::..|:....||......|...::|:| ||:..|: .::.|..:...|:             
Human   423 TEQVNEKLNAKLEELRQHVACKLDLQKLVETLEDQELK-ENVEIICNLQQLI------------- 473

  Fly   436 PPPTGQEPRQASSQNSTLMGIVEETEPKESSKVQQSMVAPTVPTTVR-CQLFNTTISPISLRASS 499
                    .|.|.:.........:|..:|.::|:      |.|.|.| ...|.|..:....:.|.
Human   474 --------TQLSDETVACTAAAIDTAVEEEAQVE------TSPETSRSSDAFTTQHALHQAQMSK 524

  Fly   500 SQRELSGIQPMEETVVA------SPQQPC-------LRRSVRLASSMRSQNYGAIPKVMNLRRST 551
            ...||:....::|.:|.      :..||.       ::.......:::.:....:.::...:::.
Human   525 EVVELNNALALKEALVRKMTQNDNQLQPIQFQYQDNIKNLELEVINLQKEKEELVRELQTAKKNV 589

  Fly   552 RLAGIREHATSVVVK------------NETDAIPHLRSTVQKKRTRNVKPAPKAWMANNTKCFLD 604
            ..|.:.||...::.:            ||...:..|:.:.::..:   |...:.||..|.:..| 
Human   590 NQAKLSEHRHKLLQELEGQIADLKKKLNEQSKLLKLKESTERTVS---KLNQEIWMMKNQRVQL- 650

  Fly   605 LLNNGNVKQLQE 616
                  ::|::|
Human   651 ------MRQMKE 656

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nodNP_511125.2 KISc 8..318 CDD:276812 119/349 (34%)
ComEA 606..>645 CDD:441164 2/11 (18%)
KIF4BNP_001092763.1 KISc_KIF4 8..337 CDD:276823 121/353 (34%)
Smc <429..>986 CDD:440809 42/266 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 494..513 7/24 (29%)
Interaction with PRC1. /evidence=ECO:0000250|UniProtKB:O95239 663..1234
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 712..737
Nuclear localization signal. /evidence=ECO:0000250|UniProtKB:O95239 793..798
Globular. /evidence=ECO:0000250 1000..1234
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1007..1030
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1052..1076
CRD, required for [4Fe-4S] cluster binding and localization to the spindle midzone and midbody during anaphase and telophase. /evidence=ECO:0000250|UniProtKB:O95239 1086..1144
SET 1086..>1126 CDD:394802
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1122..1143
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1183..1234
Blue background indicates that the domain is not in the aligned region.

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