DRSC/TRiP Functional Genomics Resources

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Protein Alignment nod and KIF4B

DIOPT Version :9

Sequence 1:NP_001285129.1 Gene:nod / 32107 FlyBaseID:FBgn0002948 Length:666 Species:Drosophila melanogaster
Sequence 2:NP_001092763.1 Gene:KIF4B / 285643 HGNCID:6322 Length:1234 Species:Homo sapiens


Alignment Length:727 Identity:176/727 - (24%)
Similarity:294/727 - (40%) Gaps:185/727 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 EGAKLSAVRIAVREAPYRQFLGRREPS-----VVQFPPWSDGKSLIV--DQNEFHFDHAFPATIS 59
            |..|...||:|:|..|    |..:|.|     .:.|.|   |::.:|  ....|.:|..|.....
Human     3 EEVKGIPVRVALRCRP----LVPKEISEGCQMCLSFVP---GETQVVVGTDKSFTYDFVFDPCTE 60

  Fly    60 QDEMYQALILPLVDKLLEGFQCTALAYGQTGTGKSYSMG--MTPPGEILPEHLGILPRALGDIFE 122
            |:|::...:.||:..:.:|:..|.|||||||:||:||||  .|...|..|. :||:||.:..:|:
Human    61 QEEVFNKAVAPLIKGIFKGYNATVLAYGQTGSGKTYSMGGAYTAEQENEPT-VGIIPRVIQLLFK 124

  Fly   123 RVTARQENNKDAIQVYASFIEIYNEKPFDLL----------------------GSTPHMPMVAAR 165
            .:..:.:..   ..:..|::|||||:..|||                      |.|....:||..
Human   125 EIDKKSDFE---FTLKVSYLEIYNEEILDLLCPSREKAQINIREDPKEGIKIVGLTEKTVLVALD 186

  Fly   166 CQRCTCLPLHSQADLHHILELGTRNRRVRPTNMNSNSSRSHAIVTIHV-------KSKTHHSRMN 223
            ...|              ||.|..:|.|..|.|||.|||||||.||.:       |:.:..|:::
Human   187 TVSC--------------LEQGNNSRTVASTAMNSQSSRSHAIFTISIEQRKKSDKNCSFRSKLH 237

  Fly   224 IVDLAGSEGVRRTGHEGVARQEGVNINLGLLSINKVVMSMAAGH--TVIPYRDSVLTTVLQASLT 286
            :|||||||..::|..||...:||:|||.|||.:..|:.::....  :.:|||||.||.:||.||.
Human   238 LVDLAGSERQKKTKAEGDRLKEGININRGLLCLGNVISALGDDKKGSFVPYRDSKLTRLLQDSLG 302

  Fly   287 AQSYLTFLACISPHQCDLSETLSTLRFGTSAKKLRLNPM-------------------------- 325
            ..|:...:||:||...:|.|||||||:...|:|::..|:                          
Human   303 GNSHTLMIACVSPADSNLEETLSTLRYADRARKIKNKPIVNIDPHTAELNHLKQQVQQLQVLLLQ 367

  Fly   326 -------------------QVARQKQSLAARTTHVFRQALCTSTAIKSNAANHNSIVVPKSKYST 371
                               .:..:.|||......:.|   |.|.|....|.....|::       
Human   368 AHGGTLPGSINAEPSENLQSLMEKNQSLVEENEKLSR---CLSKAAGQTAQMLERIIL------- 422

  Fly   372 TKPLSAVLHRTRSELGMTPKAKKRARELLE-LEETTLELSSIHIQDSSLSLLGFHSDSDKDRHLM 435
            |:.::..|:....||......|...::|:| ||:..|: .::.|..:...|:             
Human   423 TEQVNEKLNAKLEELRQHVACKLDLQKLVETLEDQELK-ENVEIICNLQQLI------------- 473

  Fly   436 PPPTGQEPRQASSQNSTLMGIVEETEPKESSKVQQSMVAPTVPTTVR-CQLFNTTISPISLRASS 499
                    .|.|.:.........:|..:|.::|:      |.|.|.| ...|.|..:....:.|.
Human   474 --------TQLSDETVACTAAAIDTAVEEEAQVE------TSPETSRSSDAFTTQHALHQAQMSK 524

  Fly   500 SQRELSGIQPMEETVVA------SPQQPC-------LRRSVRLASSMRSQNYGAIPKVMNLRRST 551
            ...||:....::|.:|.      :..||.       ::.......:::.:....:.::...:::.
Human   525 EVVELNNALALKEALVRKMTQNDNQLQPIQFQYQDNIKNLELEVINLQKEKEELVRELQTAKKNV 589

  Fly   552 RLAGIREHATSVVVK------------NETDAIPHLRSTVQKKRTRNVKPAPKAWMANNTKCFLD 604
            ..|.:.||...::.:            ||...:..|:.:.::..:   |...:.||..|.:..| 
Human   590 NQAKLSEHRHKLLQELEGQIADLKKKLNEQSKLLKLKESTERTVS---KLNQEIWMMKNQRVQL- 650

  Fly   605 LLNNGNVKQLQE 616
                  ::|::|
Human   651 ------MRQMKE 656

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nodNP_001285129.1 KISc 8..325 CDD:214526 121/356 (34%)
KISc 8..318 CDD:276812 119/349 (34%)
ComEA 540..648 CDD:224472 13/89 (15%)
KIF4BNP_001092763.1 KISc_KIF4 8..337 CDD:276823 121/353 (34%)
KISc 9..343 CDD:214526 122/358 (34%)
SbcC 406..995 CDD:223496 47/296 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 494..513 7/24 (29%)
Interaction with PRC1. /evidence=ECO:0000250|UniProtKB:O95239 663..1234
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 712..737
Nuclear localization signal. /evidence=ECO:0000250|UniProtKB:O95239 793..798
Globular. /evidence=ECO:0000250 1000..1234
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1007..1030
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1052..1076
Pre-SET <1072..1122 CDD:282838
CRD, required for [4Fe-4S] cluster binding and localization to the spindle midzone and midbody during anaphase and telophase. /evidence=ECO:0000250|UniProtKB:O95239 1086..1144
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1122..1143
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1183..1234
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0244
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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