Protein Alignment nod and KIF13B

DIOPT Version :10

• Sequence 1: NP_511125.2
• Gene: nod / 32107
• FlyBaseID: FBgn0002948
• Length: 666
• Species: Drosophila melanogaster
• Sequence 2: XP_011542759.1
• Gene: KIF13B / 23303
• HGNCID: 14405
• Length: 1847
• Species: Homo sapiens
• Alignment Length: 676
• Identity: 178/676 - (26%)
• Similarity: 283/676 - (41%)
• Gaps: 148/676 - (21%)

  Fly     7 SAVRIAVREAPYRQFLGRREPSVVQFPPWSDGKSLI-VDQNE---------------------FH 49
            |.|::|||..|    :.|||..:       ..|.:: ||.|:                     |.
Human     4 SKVKVAVRIRP----MNRRETDL-------HTKCVVDVDANKVILNPVNTNLSKGDARGQPKVFA 57

  Fly    50 FDHAF--------PATISQDEMYQALILPLVDKLLEGFQCTALAYGQTGTGKSYSMGMTPPGEIL 106
            :||.|        .....||.:::.|...::....:|:.....||||||:||||:|..|
Human    58 YDHCFWSMDESVKEKYAGQDIVFKCLGENILQNAFDGYNACIFAYGQTGSGKSYTMMGT------ 116

  Fly   107 PEHLGILPRALGDIFERVTARQENNKDAIQVYASFIEIYNEKPFDLL---GSTPHM--------- 159
            .:..|::||....:||| |.::||.:.:.:|..|::||||||..|||   ||...:
Human   117 ADQPGLIPRLCSGLFER-TQKEENEEQSFKVEVSYMEIYNEKVRDLLDPKGSRQTLKVREHSVLG 180

  Fly   160 PMVAARCQRCTCLPLHSQADLHHILELGTRNRRVRPTNMNSNSSRSHAIVTI-------HVKSKT 217
            |.|....:    |.:.|..|:..::..|.::|.|..||||..||||||:..|       .|||.|
Human   181 PYVDGLSK----LAVTSYKDIESLMSEGNKSRTVAATNMNEESSRSHAVFKITLTHTLYDVKSGT 241

  Fly   218 HH---SRMNIVDLAGSEGVRRTGHEGVARQEGVNINLGLLSINKVVMSMA---AG---HTVIPYR 273
            ..   .::::|||||||...:||..|...:||.|||..|.::..|:.::|   ||   :..:|||
Human   242 SGEKVGKLSLVDLAGSERATKTGAAGDRLKEGSNINKSLTTLGLVISALADQSAGKNKNKFVPYR 306

  Fly   274 DSVLTTVLQASLTAQSYLTFLACISPHQCDLSETLSTLRFGTSAKKLRLNPMQVARQKQSLAAR- 337
            |||||.:|:.||...|....:|.:||...:..|||||||:...||.: :|...|.....:...|
Human   307 DSVLTWLLKDSLGGNSKTAMVATVSPAADNYDETLSTLRYADRAKHI-VNHAVVNEDPNARIIRD 370

  Fly   338 ---TTHVFRQALCTSTAIKSNAANHNSIVVPKSK---YSTTKPLSAVLHRTRSELGMTPKAKKRA 396
               .....|:.|..:.|:||          |:.|   ..:.|.:..:......:|..|.:..:..
Human   371 LREEVEKLREQLTKAEAMKS----------PELKDRLEESEKLIQEMTVTWEEKLRKTEEIAQER 425

  Fly   397 RELLELEETTLELSSIHIQDSSLSLLGFHSDSD---------KDRHLMPPPTGQEPRQASSQNST 452
            ::.||....:|:.|.|.:.|....|:..::|..         |:..|:        ..|:||:..
Human   426 QKQLESLGISLQSSGIKVGDDKCFLVNLNADPALNELLVYYLKEHTLI--------GSANSQDIQ 482

  Fly   453 L--MGIVEETEPKESSKVQQSMVAPTVPTTVRCQLF---NTTISPISL----------------- 495
            |  |||:.|....:.:...|.|:.|...|    :.|   ::..|||.|
Human   483 LCGMGILPEHCIIDITSEGQVMLTPQKNT----RTFVNGSSVSSPIQLHHGDRILWGNNHFFRLN 543

  Fly   496 ---RASSSQRELSGIQPMEETVVASPQQPCLRRSVRLASSMRSQNYGAIPKVMNLRRSTRLAGIR 557
               :...::||.....|..:...:|.|......|....||..:.||    :...:..:.:..|..
Human   544 LPKKKKKAEREDEDQDPSMKNENSSEQLDVDGDSSSEVSSEVNFNY----EYAQMEVTMKALGSN 604

  Fly   558 EHATSVVVKNETDAIPHLRSTVQKKR 583
            :...|::...|.......||.::::|
Human   605 DPMQSILNSLEQQHEEEKRSALERQR 630

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nod	NP_511125.2	KISc	8..318	CDD:276812	119/367 (32%)
		ComEA	606..>645	CDD:441164
KIF13B	XP_011542759.1	KISc_KIF1A_KIF1B	4..360	CDD:276816	123/378 (33%)
		Kinesin_assoc	357..469	CDD:465047	20/121 (17%)
		FHA_KIF13B	447..545	CDD:438782	21/109 (19%)
		COG4913	<611..>760	CDD:443941	4/20 (20%)
		KIF1B	756..802	CDD:463574
		bMERB_dom	<1099..1143	CDD:463467
		DUF3694	<1221..1278	CDD:463599
		PHA03247	<1445..1704	CDD:223021
		CAP_GLY	1725..1788	CDD:460154