DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nod and KIF21B

DIOPT Version :9

Sequence 1:	NP_001285129.1	Gene:	nod / 32107	FlyBaseID:	FBgn0002948	Length:	666	Species:	Drosophila melanogaster
Sequence 2:	NP_001239029.1	Gene:	KIF21B / 23046	HGNCID:	29442	Length:	1637	Species:	Homo sapiens

Alignment Length:	666	Identity:	178/666 - (26%)
Similarity:	268/666 - (40%)	Gaps:	176/666 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MEGAKLSAVRIAVREAPYRQFLGRRE-------PSVVQFPPWSDGKSLIVDQNEFHFDHAFPATI 58
            |.|.....|::|||..|.   |.:.:       .||....|    :.|:.....|.:|..|....
Human     1 MAGQGDCCVKVAVRIRPQ---LSKEKIEGCHICTSVTPGEP----QVLLGKDKAFTYDFVFDLDT 58

  Fly    59 SQDEMYQALILPLVDKLLEGFQCTALAYGQTGTGKSYSMGMTPPGEILPEHLGILPRALGDIFER 123
            .|:::|...:..|::...||:..|.|||||||.||:|:||.........|..||:|||:..:|..
Human    59 WQEQIYSTCVSKLIEGCFEGYNATVLAYGQTGAGKTYTMGTGFDMATSEEEQGIIPRAIAHLFGG 123

  Fly   124 VTARQENNKD------AIQVYASFIEIYNEKPFDLLGST--PHMPMVAARCQR------------ 168
            :..|:...::      ..:|.|.|:|:|||:..||..||  |.     .|.:|
Human   124 IAERKRRAQEQGVAGPEFKVSAQFLELYNEEILDLFDSTRDPD-----TRHRRSNIKIHEDANGG 183

  Fly   169 -----CTCLPLHSQADLHHILELGTRNRRVRPTNMNSNSSRSHAIVTIHV--------------- 213
                 .|...:|||.:|...|:.|..:|....|.||..|||||||.|||:
Human   184 IYTTGVTSRLIHSQEELIQCLKQGALSRTTASTQMNVQSSRSHAIFTIHLCQMRMCTQPDLVNEA 248

  Fly   214 ------------KSKTHHSRMNIVDLAGSEGVRRTGHEGVARQEGVNINLGLLSINKVV-----M 261
                        :.:|..::.:.|||||||.::|||..|...:||::||.|||::..|:     .
Human   249 VTGLPDGTPPSSEYETLTAKFHFVDLAGSERLKRTGATGERAKEGISINCGLLALGNVISALGDQ 313

  Fly   262 SMAAGHTVIPYRDSVLTTVLQASLTAQSYLTFLACISPHQCDLSETLSTLRFGTSAKKLRLNPMQ 326
            |....|  :|||||.||.:||.||...|....:||:||...|..|||:||::...|:.:: |.:.
Human   314 SKKVVH--VPYRDSKLTRLLQDSLGGNSQTIMIACVSPSDRDFMETLNTLKYANRARNIK-NKVV 375

  Fly   327 VARQK--QSLAARTTHVFRQAL------CTSTAIKSNAANHNSIVVPKSKYSTTKPLSAVLHRTR 383
            |.:.|  |.::|....:.|..:      .....|..:.|         ..||.....:|:|.:..
Human   376 VNQDKTSQQISALRAEIARLQMELMEYKAGKRVIGEDGA---------EGYSDLFRENAMLQKEN 431

  Fly   384 SELGMTPKAKKRARELLELEETTLELSSIHIQDSSLSLLGFHSDSDKDRHLMPPPTGQEPRQASS 448
            ..|.:..||.:.|.:.:....|  :|.|   |:::| ||....|            |.|...|..
Human   432 GALRLRVKAMQEAIDAINNRVT--QLMS---QEANL-LLAKAGD------------GNEAIGALI 478

  Fly   449 QNSTLMGIVEETEPK--ESSKVQQSMVAPTVPTTVRCQLFNTTISPISLRASSSQRELSGIQPME 511
            ||  .:..:||...|  ||..:.:|:.......:.|        ||.||.||.:.....|
Human   479 QN--YIREIEELRTKLLESEAMNESLRRSLSRASAR--------SPYSLGASPAAPAFGG----- 528

  Fly   512 ETVVASPQQPCLRRSVRLASSMRSQNYGAIPKVMNLRRSTRLAGIREHATSVVVKNETDAIPHLR 576
                 ||           ||||                        |.|:.|:.:.:.|.
Human   529 -----SP-----------ASSM------------------------EDASEVIRRAKQDL----- 548

  Fly   577 STVQKKRTRNVKPAPK 592
            ..::||..|..:.:|:
Human   549 ERLKKKEVRQRRKSPE 564

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nod	NP_001285129.1	KISc	8..325	CDD:214526	120/380 (32%)
		KISc	8..318	CDD:276812	118/373 (32%)
		ComEA	540..648	CDD:224472	8/53 (15%)
KIF21B	NP_001239029.1	KISc_KIF4	7..371	CDD:276823	119/377 (32%)
		KISc	9..377	CDD:214526	120/382 (31%)
		Interaction with TRIM3. /evidence=ECO:0000250\|UniProtKB:Q9QXL1	400..1099		51/252 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	509..538		15/81 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	552..628		4/13 (31%)
		PKK	660..794	CDD:289257
		JAKMIP_CC3	678..806	CDD:292653
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	830..865
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	880..906
		Prefoldin	954..1102	CDD:298833
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1194..1251
		WD40	1305..1613	CDD:238121
		WD40	1306..>1614	CDD:225201
		WD 1	1306..1343
		WD40 repeat	1312..1346	CDD:293791
		WD 2	1346..1384
		WD40 repeat	1351..1387	CDD:293791
		WD40 repeat	1407..1450	CDD:293791
		WD 3	1410..1448
		WD 4	1451..1493
		WD40 repeat	1456..1500	CDD:293791
		WD 5	1502..1539
		WD40 repeat	1509..1541	CDD:293791
		WD 6	1543..1582
		WD40 repeat	1548..1572	CDD:293791
		WD 7	1585..1622
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0244
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810