DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nod and kif11

DIOPT Version :9

Sequence 1:	NP_001285129.1	Gene:	nod / 32107	FlyBaseID:	FBgn0002948	Length:	666	Species:	Drosophila melanogaster
Sequence 2:	NP_775368.2	Gene:	kif11 / 195818	ZFINID:	ZDB-GENE-020426-1	Length:	1062	Species:	Danio rerio

Alignment Length:	722	Identity:	185/722 - (25%)
Similarity:	302/722 - (41%)	Gaps:	176/722 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 GRREPSVVQFPPWS-----DGKSLIV--DQNE------------------FHFDHAFPATISQDE 62
            ||....||:..|::     .|...:|  |||.                  :.||..|..:..|.|
Zfish    15 GRNIQVVVRCRPFNTVERKSGSHTVVECDQNRKEVIMRTGGATDKAARKTYTFDMVFGPSAKQIE 79

  Fly    63 MYQALILPLVDKLLEGFQCTALAYGQTGTGKSYSM--GMTPPGEILPEH---LGILPRALGDIFE 122
            :|::::.|::|:::.|:.||..|||||||||:::|  ..:|..|...|.   .||:||.|..|||
Zfish    80 VYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTMEGDRSPNEEFTWEEDPLAGIIPRTLHQIFE 144

  Fly   123 RVTARQENNKDAIQVYASFIEIYNEKPFDLLGSTPHMPMVAARCQ--------------RCTCLP 173
            :::    ||.....|..|.:|||||:.||||...|.   |..|.|              ....:.
Zfish   145 KLS----NNGTEFSVKVSLLEIYNEELFDLLSPAPD---VTERLQLFDDPRNKRGVTIKGLEEIT 202

  Fly   174 LHSQADLHHILELGTRNRRVRPTNMNSNSSRSHAI--VTIHVKSKT-------HHSRMNIVDLAG 229
            :|::.:::.|||.|...|:...|.||:.|||||::  ||||:|..|       ...::|:|||||
Zfish   203 VHNKNEVYQILERGAAKRKTASTLMNAYSSRSHSVFSVTIHMKEITLDGEELVKIGKLNLVDLAG 267

  Fly   230 SEGVRRTGHEGVARQEGVNINLGLLSINKVVMSMAAGHTVIPYRDSVLTTVLQASLTAQSYLTFL 294
            ||.:.|:|......:|..|||..||::.:|:.::......:|||:|.||.:||.||..::..:.:
Zfish   268 SENIGRSGAVDKRAREAGNINQSLLTLGRVIKALVERGPHVPYRESKLTRILQDSLGGRTKTSII 332

  Fly   295 ACISPHQCDLSETLSTLRFGTSAKKLRLNP----------------MQVARQKQSLAA-RTTH-V 341
            |.:||...:|.||||||.:...||.:...|                .::.|.|:.||| |..| |
Zfish   333 ATVSPASINLEETLSTLDYANRAKSIMNKPEVNQKLTKRTLIKEYTEEIERLKRDLAATRDKHGV 397

  Fly   342 FRQALCTSTAIKSNAANHNSIVVPKSKYST--TKPLSAVLHRTRSELGMTPKAKKRARELLELEE 404
            :...        .|....|..:|.:.:..|  |:.::|:....:..:.:...:|::      ||:
Zfish   398 YLSV--------DNYETLNGKIVSQEEQITEYTERIAAMEEELKKIIDLFTDSKQK------LEQ 448

  Fly   405 TTLELSSIHIQDSSLSLLGFHSDSDKDRHLMPPPTGQEPRQASSQNSTLMGIVEETEPKESSKVQ 469
            .|.:|     ||.:..|...|.|..:.||                                 ::.
Zfish   449 CTEDL-----QDKNQRLEEAHKDLSETRH---------------------------------RLN 475

  Fly   470 QSMVAPTVPTTVRCQLFNTTISPISLRASSSQRELSGIQ---------PMEETVVASPQQPCLR- 524
            |.....|...|....|:||....:| .|.:|.:::.|:.         .:..:.|......|:.
Zfish   476 QEEFISTQLQTNESHLYNTADQLLS-TAEASTQDVGGLHAKLQRKKDVELHNSKVQESFSQCMEN 539

  Fly   525 --RSVRLASSMRSQNYGAIPKVMNLRRSTRLAGIREHATSVVVKNETDAIPHLRSTVQKKRTRNV 587
              .|::.:...:||.:.|   :::..||:  .|...:....|.|....|:....|:::......|
Zfish   540 CYNSMQTSLKEQSQKHAA---MIDYYRSS--VGELLNTNGKVFKETLSAVCESYSSIKGAVGEGV 599

  Fly   588 KPAPKAWMANNTKCFLDLLNN------------GNVKQLQEIPGIGPKSAFSL------ALHRSR 634
            :.. |..:.|..|...|..|:            ..|...|.:|||  :|..|:      .||:
Zfish   600 ERC-KEQVLNQEKLSQDAQNSILEILDEHKQHLEEVLVAQAVPGI--RSVMSMNDNLKQTLHK-- 659

  Fly   635 LGCFENL 641
               :.||
Zfish   660 ---YHNL 663

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nod	NP_001285129.1	KISc	8..325	CDD:214526	119/370 (32%)
		KISc	8..318	CDD:276812	116/347 (33%)
		ComEA	540..648	CDD:224472	25/120 (21%)
kif11	NP_775368.2	KISc_BimC_Eg5	15..367	CDD:276815	119/358 (33%)
		KISc	17..365	CDD:214526	117/354 (33%)
		Microtub_bind	926..1061	CDD:290642
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170594330
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.840