DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nod and bmk-1

DIOPT Version :9

Sequence 1:	NP_001285129.1	Gene:	nod / 32107	FlyBaseID:	FBgn0002948	Length:	666	Species:	Drosophila melanogaster
Sequence 2:	NP_001379525.1	Gene:	bmk-1 / 179948	WormBaseID:	WBGene00000257	Length:	963	Species:	Caenorhabditis elegans

Alignment Length:	760	Identity:	175/760 - (23%)
Similarity:	300/760 - (39%)	Gaps:	180/760 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 SAVRIAVREAPYRQFLGRREPSVVQFPPWSDGKSLIVDQNEFH--FDHAFPATISQDEMYQALIL 69
            |.:|:|||..|...  ..|............||..|..:.:..  |...:....:|:|:|..|:.
Worm    17 SNLRVAVRIRPMNG--TERSEKCTNVVKVDKGKQAIELKGKSFGPFFRTYDPDTTQEEIYSDLVS 79

  Fly    70 PLVDKLLEGFQCTALAYGQTGTGKSYSM--GMTPPGEILPE-HLGILPRALGDIFERVTARQENN 131
            ..:.|::.||.||..|||||||||:::|  |.|.......: ..||:|||:.||||::   :...
Worm    80 SQIKKVIAGFNCTVFAYGQTGTGKTFTMEGGRTDAKSSTDDPTTGIIPRAVEDIFEQL---ERCG 141

  Fly   132 KDAIQVYASFIEIYNEKPFDLLGSTPH--------------MPMVAARCQRCTCLPLHSQADLHH 182
            .:...:..|:||:|||:.||||.||.:              ..::.:..:.   :|:.:::|:..
Worm   142 CEEYSLRVSYIELYNEELFDLLASTDNEDRERLRIFDDPNKKGVIVSGVEE---VPVRNRSDVFK 203

  Fly   183 ILELGTRNRRVRPTNMNSNSSRSHAIVTIHV---------KSKTHHSRMNIVDLAGSEGVRRTGH 238
            :|:||...||...|.||.:|||||::..::|         :......::|:|||||||.:.|:|.
Worm   204 LLQLGAEKRRTAATLMNMHSSRSHSLFMVNVVIRENTTTGEELVKQGKLNLVDLAGSENIGRSGA 268

  Fly   239 EGVARQEGVNINLGLLSINKVVMSMAAGHTVIPYRDSVLTTVLQASLTAQSYLTFLACISPHQCD 303
            :|...:|..:||..||::.:|:..:......||||:|.||.:||.||...:..:.:|.:||...:
Worm   269 QGNRAKEAGSINQSLLTLGRVIRLLTTNGQHIPYRESKLTRLLQDSLGGSTITSLIATLSPSSSN 333

  Fly   304 LSETLSTLRFGTSAKKLRLNP-------------------------MQVARQKQS-LAARTTH-V 341
            ..|:.|||.:...|..::..|                         ::.||:|.. :.::.:| .
Worm   334 FEESQSTLEYAMRAANIKNKPVCNTKLSKKTILKEYSDEIEKLRRDLRAAREKNGVIISQESHDE 398

  Fly   342 FRQALCTSTAIKSNAANHNSIVVPKSKYSTTKPLS-----AVLHRTRSELGMTPKAKKRARELLE 401
            |::   .|..:: ....|....|.:.:..|...:.     ..|:..:.||  ..:.:.|.||:..
Worm   399 FQK---NSEKVQ-ELEQHLDNAVDRLRIFTEDQMHMDEQYRQLYERKGEL--EDRLRDRIREMAV 457

  Fly   402 LEETTLELSSI---HIQDSSLSLLGFHSDSDKDRHLMPPPTG----------------QEPRQAS 447
            .|:...:.:.:   ||:...|    .|:.:.|....:....|                .|..:|.
Worm   458 KEKELADTNDVLNKHIEVIGL----MHTSALKAFDQLTTSQGAADEMQTDLRAFWRKVDEMERAD 518

  Fly   448 SQNSTLMGIVEETEPKES------SKVQQSMVAPTVPTTVRCQLFNTTISPISLRASSSQREL-S 505
            .:|..   :::....|.|      ||:..|:.|   ...:..:..:..|.|......|:.|:: |
Worm   519 DRNKI---VIDHFSKKMSDFIDTTSKLTNSLKA---DGDLLSKKLSENICPHVKSMESAHRDIES 577

  Fly   506 GIQPMEETVVASPQQPCLRRSVRLASSMRSQNYGAIPKVMNLRRSTRL-----------AGIREH 559
            ....||...:      |:.:....|......|..||.....:|..|.:           |..:|.
Worm   578 TAMDMETHAI------CIMKKSSEAEKKVIDNMTAISMENRIRLETVMKTCDDFYKSYSAKSQEF 636

  Fly   560 ATSVV---------VKNETDAIPHLRSTV--------------QKKRTRNVKPA-------PKAW 594
            ...||         |.:.|:.:..|.||:              .||...:|:.|       .||.
Worm   637 TQMVVDKLDEVKKQVSDFTEDMKPLVSTLHQTTCDSYEARTNESKKNVEHVRAACSSMADSMKAL 701

  Fly   595 M---------------------ANNTKCFLDLLNNGN--VKQLQE 616
            |                     .||.:..||.||...  |:.|::
Worm   702 MLQVEQLSTKVAENHEKQVIADQNNQETILDTLNTAETVVQSLED 746

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nod	NP_001285129.1	KISc	8..325	CDD:214526	105/369 (28%)
		KISc	8..318	CDD:276812	103/337 (31%)
		ComEA	540..648	CDD:224472	28/141 (20%)
bmk-1	NP_001379525.1	Motor_domain	17..359	CDD:419868	106/349 (30%)
bmk-1	NP_001379525.1	CCDC158	<365..>839	CDD:318193	69/404 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160166036
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840