Protein Alignment nod and Kif5b

DIOPT Version :10

• Sequence 1: NP_511125.2
• Gene: nod / 32107
• FlyBaseID: FBgn0002948
• Length: 666
• Species: Drosophila melanogaster
• Sequence 2: NP_032474.2
• Gene: Kif5b / 16573
• MGIID: 1098268
• Length: 963
• Species: Mus musculus
• Alignment Length: 734
• Identity: 183/734 - (24%)
• Similarity: 307/734 - (41%)
• Gaps: 187/734 - (25%)

  Fly     9 VRIAVREAPYRQF-LGRREPSVVQFPPWSDGK-SLIVDQNEFHFDHAFPATISQDEMYQALILPL 71
            :::..|..|..:. :.|.:..|.:|    .|: ::::....:.||..|.::.||:::|......:
Mouse     9 IKVMCRFRPLNESEVNRGDKYVAKF----QGEDTVMIASKPYAFDRVFQSSTSQEQVYNDCAKKI 69

  Fly    72 VDKLLEGFQCTALAYGQTGTGKSYSMGMTPPGEIL-PEHLGILPRALGDIFERVTARQENNKDAI 135
            |..:|||:..|..|||||.:||:::|    .|::. ||.:||:||.:.|||..:.:..||.:..|
Mouse    70 VKDVLEGYNGTIFAYGQTSSGKTHTM----EGKLHDPEGMGIIPRIVQDIFNYIYSMDENLEFHI 130

  Fly   136 QVYASFIEIYNEKPFDLLGSTP----------HMPMVAARCQRCTCLPLHSQADLHHILELGTRN 190
            :|  |:.|||.:|..|||..:.          .:|.|....:|..|.|    .::...::.|..|
Mouse   131 KV--SYFEIYLDKIRDLLDVSKTNLSVHEDKNRVPYVKGCTERFVCSP----DEVMDTIDEGKSN 189

  Fly   191 RRVRPTNMNSNSSRSHAIVTIHVKSKTHHS------RMNIVDLAGSEGVRRTGHEGVARQEGVNI 249
            |.|..||||.:|||||:|..|:||.:...:      ::.:|||||||.|.:||.||....|..||
Mouse   190 RHVAVTNMNEHSSRSHSIFLINVKQENTQTEQKLSGKLYLVDLAGSEKVSKTGAEGAVLDEAKNI 254

  Fly   250 NLGLLSINKVVMSMAAGHTVIPYRDSVLTTVLQASLTAQSYLTFLACISPHQCDLSETLSTLRFG 314
            |..|.::..|:.::|.|.|.:|||||.:|.:||.||......|.:.|.||...:.|||.|||.||
Mouse   255 NKSLSALGNVISALAEGSTYVPYRDSKMTRILQDSLGGNCRTTIVICCSPSSYNESETKSTLLFG 319

  Fly   315 TSAKKLR--------------------------------------LN--------PM--QVARQK 331
            ..||.::                                      ||        |:  |..::|
Mouse   320 QRAKTIKNTVCVNVELTAEQWKKKYEKEKEKNKTLRNTIQWLENELNRWRNGETVPIDEQFDKEK 384

  Fly   332 QSLAARTTHVFRQALCTS----TAI---------------------------KSNAANHNSIVVP 365
            .:|.|.|..  :....||    .|:                           |....|..|.:|.
Mouse   385 ANLEAFTAD--KDIAITSDKPAAAVGMAGSFTDAERRKCEEELAKLYKQLDDKDEEINQQSQLVE 447

  Fly   366 KSK----------YSTTKP---LSAVLHRTRSELGMTPKAKKRARELL---------------EL 402
            |.|          .||.:.   :.|.|:|.::|   ...:|:..:|:|               |:
Mouse   448 KLKTQMLDQEELLASTRRDQDNMQAELNRLQAE---NDASKEEVKEVLQALEELAVNYDQKSQEV 509

  Fly   403 EETT--LELSSIHIQDSSLSLLGFHSDSDKDRHLMPPPTGQEPRQASSQNSTLM------GIV-- 457
            |:.|  .||.|..:...|.:|....::..|.:.:    |..:.::|:...::|:      ||.
Mouse   510 EDKTKEYELLSDELNQKSATLASIDAELQKLKEM----TNHQKKRAAEMMASLLKDLAEIGIAVG 570

  Fly   458 --EETEPKESSKVQQ---------SMVAPTVPTTV-RCQLFNTTISPISLRASSSQRELSGIQ-- 508
              :..:|:.:..:.:         |.:...|.|.| ||:...:|.:..:.:...:::||:..|
Mouse   571 NNDVKQPEGTGMIDEEFTVARLYISKMKSEVKTMVKRCKQLESTQTESNKKMEENEKELAACQLR 635

  Fly   509 -PMEETVVASPQ---QPCLRRSVRLASSMRSQNYGAIPKVMNLRRSTRLAGI-REHATSVVVKNE 568
             ...|..:.|..   |...::..:|..|:.|..    .:::.||...::..: :||...|...||
Mouse   636 ISQHEAKIKSLTEYLQNVEQKKRQLEESVDSLG----EELVQLRAQEKVHEMEKEHLNKVQTANE 696

  Fly   569 T-----DAIPHLRSTVQKK 582
            .     ..|...|.|.||:
Mouse   697 VKQAVEQQIQSHRETHQKQ 715

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nod	NP_511125.2	KISc	8..318	CDD:276812	112/327 (34%)
		ComEA	606..>645	CDD:441164
Kif5b	NP_032474.2	KISc_KHC_KIF5	6..325	CDD:276820	114/329 (35%)
		SMC_prok_B	<417..803	CDD:274008	58/310 (19%)
		Khc_CBD_cc	834..903	CDD:467880
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	908..963
		Globular	915..963