DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nod and Kif5a

DIOPT Version :9

Sequence 1:	NP_001285129.1	Gene:	nod / 32107	FlyBaseID:	FBgn0002948	Length:	666	Species:	Drosophila melanogaster
Sequence 2:	NP_001034089.1	Gene:	Kif5a / 16572	MGIID:	109564	Length:	1027	Species:	Mus musculus

Alignment Length:	685	Identity:	175/685 - (25%)
Similarity:	289/685 - (42%)	Gaps:	137/685 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 AVRIAVREAPYRQFLGRREPSVVQFPPWSDGKSLIVDQNEFHFDHAFPATISQDEMYQALILPLV 72
            ::::..|..|..|....|....:  |.:....|:|:....:.||..||...:|:::|.|..:.:|
Mouse     9 SIKVLCRFRPLNQAEILRGDKFI--PIFQGDDSVIIGGKPYVFDRVFPPNTTQEQVYHACAMQIV 71

  Fly    73 DKLLEGFQCTALAYGQTGTGKSYSMGMTPPGEIL-PEHLGILPRALGDIFERVTARQENNKDAIQ 136
            ..:|.|:..|..|||||.:||:::|    .|::. |:.:||:||...|||..:.:..||.:..|:
Mouse    72 KDVLAGYNGTIFAYGQTSSGKTHTM----EGKLHDPQLMGIIPRIARDIFNHIYSMDENLEFHIK 132

  Fly   137 VYASFIEIYNEKPFDLLGSTP----------HMPMVAARCQRCTCLPLHSQADLHHILELGTRNR 191
            |  |:.|||.:|..|||..|.          .:|.|    :.||...:.|..::..:::.|..||
Mouse   133 V--SYFEIYLDKIRDLLDVTKTNLSVHEDKNRVPFV----KGCTERFVSSPEEILDVIDEGKSNR 191

  Fly   192 RVRPTNMNSNSSRSHAIVTIHVKSKTHHS------RMNIVDLAGSEGVRRTGHEGVARQEGVNIN 250
            .|..||||.:|||||:|..|::|.:...:      ::.:|||||||.|.:||.||....|..|||
Mouse   192 HVAVTNMNEHSSRSHSIFLINIKQENVETEQKLSGKLYLVDLAGSEKVSKTGAEGAVLDEAKNIN 256

  Fly   251 LGLLSINKVVMSMAAG-HTVIPYRDSVLTTVLQASLTAQSYLTFLACISPHQCDLSETLSTLRFG 314
            ..|.::..|:.::|.| .:.:|||||.:|.:||.||......|...|.||...:.:||.|||.||
Mouse   257 KSLSALGNVISALAEGTKSYVPYRDSKMTRILQDSLGGNCRTTMFICCSPSSYNDAETKSTLMFG 321

  Fly   315 TSAKKLRLNPMQVARQKQSLAARTTHVFRQALCTSTAIKSNAANHNSIVVP--KSKYSTTKPLSA 377
            ..||                                .||:.|:.:..:...  |.||...|..:
Mouse   322 QRAK--------------------------------TIKNTASVNLELTAEQWKKKYEKEKEKT- 353

  Fly   378 VLHRTRSELGMTPKAKKRARELLELE-------ETTLELSSIHIQDSSLSLLGFHSDSDKDRHLM 435
                         ||:|.....||.|       |...|...:..:||:|...........|...:
Mouse   354 -------------KAQKETIAKLEAELSRWRNGENVPETERLAGEDSALGAELCEETPVNDNSSI 405

  Fly   436 PPPTGQEPRQASSQNSTLMGIVEETEPKESSKVQQSMVAPTVPTTVRCQLFNTTISPISLRASSS 500
            ......|.||...:.  :..:.::.:.|:....|||.:.    ..::.|:.:.....:|.|..:.
Mouse   406 VVRIAPEERQKYEEE--IRRLYKQLDDKDDEINQQSQLI----EKLKQQMLDQEELLVSTRGDNE 464

  Fly   501 --QRELSG---------------IQPMEETVVASPQQPCLRRSVRLASSMRSQNYGAIPKVMNLR 548
              |||||.               :|.:||..|...|:.      :.......||...:.::.
Mouse   465 KVQRELSHLQSENDAAKDEVKEVLQALEELAVNYDQKS------QEVEEKSQQNQLLVDELS--- 520

  Fly   549 RSTRLAGIREHATSVVVKNETDAIPHLRSTVQKKRTRNVKPAPKAWMANNTKCFLDLLNNGNVKQ 613
                    ::.||.:.:::|...:..: |..|:||...|...    :..:...|..::.||.:|.
Mouse   521 --------QKVATMLSLESELQRLQEV-SGHQRKRIAEVLNG----LMRDLSEFSVIVGNGEIKL 572

  Fly   614 LQEIPGIGPKSAFSLA-LHRSRLGCFENLFQVKSL 647
            ..||.| ..:..|::| |:.|::..     :|||:
Mouse   573 PVEISG-AIEEEFTVARLYISKIKS-----EVKSV 601

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nod	NP_001285129.1	KISc	8..325	CDD:214526	112/334 (34%)
		KISc	8..318	CDD:276812	110/327 (34%)
		ComEA	540..648	CDD:224472	22/109 (20%)
Kif5a	NP_001034089.1	KISc_KHC_KIF5	7..327	CDD:276820	112/361 (31%)
		Microtubule-binding	174..315		52/140 (37%)
		Necessary for interaction with ZFYVE27. /evidence=ECO:0000269\|PubMed:21976701	271..361		34/135 (25%)
		Interaction with BICD2. /evidence=ECO:0000250\|UniProtKB:Q12840	353..1027		56/297 (19%)
		Smc	<412..759	CDD:224117	44/224 (20%)
		DUF5401	<630..>902	CDD:375164
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	906..937
		Globular	907..1027
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910