DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nod and Kif4

DIOPT Version :9

Sequence 1:	NP_001285129.1	Gene:	nod / 32107	FlyBaseID:	FBgn0002948	Length:	666	Species:	Drosophila melanogaster
Sequence 2:	NP_032472.2	Gene:	Kif4 / 16571	MGIID:	108389	Length:	1231	Species:	Mus musculus

Alignment Length:	711	Identity:	182/711 - (25%)
Similarity:	298/711 - (41%)	Gaps:	187/711 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 EGAKLSAVRIAVREAPYRQFLGRRE-----PSVVQFPPWSDGKSLIVDQNE--FHFDHAFPATIS 59
            |..|...||:|:|..|    |..:|     .:.:.|.|   |:..:|..|:  |.:|..|..:..
Mouse     3 EEVKGIPVRVALRCRP----LVSKEIKEGCQTCLSFVP---GEPQVVVGNDKSFTYDFVFDPSTE 60

  Fly    60 QDEMYQALILPLVDKLLEGFQCTALAYGQTGTGKSYSMGMTPPGEILPEH---LGILPRALGDIF 121
            |:|::...:.||:..:.:|:..|.|||||||:||:||||.....|  .||   :|::||.:..:|
Mouse    61 QEEVFNTAVAPLIKGVFKGYNATVLAYGQTGSGKTYSMGGAYTAE--QEHDSAIGVIPRVIQLLF 123

  Fly   122 ERVTARQENNKDAIQ--VYASFIEIYNEKPFDLL-----------------------GSTPHMPM 161
            :.:     |.|...:  :..|::|||||:..|||                       |.|....:
Mouse   124 KEI-----NKKSDFEFTLKVSYLEIYNEEILDLLCSSREKATQINIREDPKEGIKIVGLTEKTVL 183

  Fly   162 VAARCQRCTCLPLHSQADLHHILELGTRNRRVRPTNMNSNSSRSHAIVTIHV-------KSKTHH 219
            ||:....|              ||.|..:|.|..|.|||.|||||||.||.:       |:.:..
Mouse   184 VASDTVSC--------------LEQGNNSRTVASTAMNSQSSRSHAIFTISIEQRKKNDKNSSFR 234

  Fly   220 SRMNIVDLAGSEGVRRTGHEGVARQEGVNINLGLLSINKVVMSMAAGH--TVIPYRDSVLTTVLQ 282
            |::::|||||||..::|..||...:||:|||.|||.:..|:.::....  ..:|||||.||.:||
Mouse   235 SKLHLVDLAGSERQKKTKAEGDRLREGININRGLLCLGNVISALGDDKKGNFVPYRDSKLTRLLQ 299

  Fly   283 ASLTAQSYLTFLACISPHQCDLSETLSTLRFGTSAKKLRLNP-MQVARQKQSLAARTTHVFRQA- 345
            .||...|:...:||:||...:|.|||:|||:...|:|::..| :.:..|    ||...|:.:|.
Mouse   300 DSLGGNSHTLMIACVSPADSNLEETLNTLRYADRARKIKNKPIINIDPQ----AAELNHLKQQVQ 360

  Fly   346 -------------------LCTSTAIKSNAANHNSIVVPKSKYS---------TTKPLSAVLHRT 382
                               :..|..::|....:.|:|....|.|         |.:.|..::...
Mouse   361 QLQILLLQAHGGTLPGDINVEPSENLQSLMEKNQSLVEENEKLSRGLSEAAGQTAQMLERIILTE 425

  Fly   383 RSELGMTPKAKKRAR------ELLELEETTLELSSIHIQDSSLSLLGFHSDSDKDRHLMPPPTGQ 441
            ::...|..|.::..|      :|.:|.||        ::|..|          |:...:.....|
Mouse   426 QANEKMNAKLEELRRHAACKVDLQKLVET--------LEDQEL----------KENIEIICNLQQ 472

  Fly   442 EPRQASSQNSTLMGIVEETEPKESSKVQQSMVAPTVPTTVR-CQLFNTTISPISLRASSSQREL- 504
            ...|.|.:.:..|....:|..:..::||.|      |.|.| ..:|:|   ..:||.:...:||
Mouse   473 VIAQLSDEAAACMTATIDTAGEADTQVQSS------PDTSRSSDVFST---QHALRQAQMSKELI 528

  Fly   505 --------------------SGIQPME----------ETVVASPQQPCLRRSVRLASSMRSQNYG 539
                                :.:||::          |:.|.|.|    |....|...:::....
Mouse   529 ELNKALALKEALAKKMTQNDNQLQPIQFQYQDNIKNLESEVLSLQ----REKEELVLELQTAKKD 589

  Fly   540 AIPKVMNLRRSTRL-----------AGIREHATSVVVKNETD-AIPHLRSTVQKKRTRNVK 588
            |....::.||..||           ..::|.:..:.:|..|: .:..|...::..:.:.|:
Mouse   590 ANQAKLSERRRKRLQELEGQIADLKKKLQEQSKLLKLKESTEHTVSKLNQEIRMMKNQRVQ 650

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nod	NP_001285129.1	KISc	8..325	CDD:214526	122/361 (34%)
		KISc	8..318	CDD:276812	119/353 (34%)
		ComEA	540..648	CDD:224472	10/61 (16%)
Kif4	NP_032472.2	KISc_KIF4	8..338	CDD:276823	121/357 (34%)
		KISc	9..344	CDD:214526	122/362 (34%)
		SbcC	407..995	CDD:223496	47/275 (17%)
		Globular	1001..1231
		Pre-SET	<1070..1120	CDD:282838
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1189..1212
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0244
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810