DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nod and Kif21a

DIOPT Version :9

Sequence 1:	NP_001285129.1	Gene:	nod / 32107	FlyBaseID:	FBgn0002948	Length:	666	Species:	Drosophila melanogaster
Sequence 2:	XP_017171930.1	Gene:	Kif21a / 16564	MGIID:	109188	Length:	1685	Species:	Mus musculus

Alignment Length:	759	Identity:	165/759 - (21%)
Similarity:	280/759 - (36%)	Gaps:	256/759 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 FHFDHAFPATISQDEMYQALILPLVDKLLEGFQCTALAYGQTGTGKSYSMGMTPPGEILPEHLGI 112
            |.||:.|.....|:::|...|..|::...||:..|..||||||.||:|:||......|:.|..||
Mouse    57 FTFDYVFDIDSQQEQIYTQCIEKLIEGCFEGYNATVFAYGQTGAGKTYTMGTGFDVNIMEEEQGI 121

  Fly   113 LPRALGDIFERVTARQENNKDAI---------QVYASFIEIYNEKPFDLLGSTPHMPMVAARCQR 168
            :.||:..:|:.:   .|....||         :|.|.|:|:|||:..||..:|..   :.|:.::
Mouse   122 ISRAVRHLFKSI---DEKKTSAIKNGLPPPEFKVNAQFLELYNEEVLDLFDTTRD---IDAKNKK 180

  Fly   169 -----------------CTCLPLHSQADLHHILELGTRNRRVRPTNMNSNSSRSHAIVTIHV--- 213
                             .|...::::.::...|:||..:|....|.||..|||||||.||||
Mouse   181 SNIRIHEDSTGGIYTVGVTTRTVNTEPEMMQCLKLGALSRTTASTQMNVQSSRSHAIFTIHVCQT 245

  Fly   214 ------------------------KSKTHHSRMNIVDLAGSEGVRRTGHEGVARQEGVNINLGLL 254
                                    :.:|..::.:.|||||||.::|||..|...:||::||.|||
Mouse   246 RVCPQTDAENATDNKLISESSPMNEFETLTAKFHFVDLAGSERLKRTGATGERAKEGISINCGLL 310

  Fly   255 SINKVVMSMA-----AGHTVIPYRDSVLTTVLQASLTAQSYLTFLACISPHQCDLSETLSTLRFG 314
            ::..|:.::.     |.|  :|||||.||.:||.||...|....:||:||...|..|||:||::.
Mouse   311 ALGNVISALGDKSKRATH--VPYRDSKLTRLLQDSLGGNSQTIMIACVSPSDRDFMETLNTLKYA 373

  Fly   315 TSAK------------------------------------------------------------- 318
            ..|:
Mouse   374 NRARNIKNKVMVNQDRASQQINALRSEITRLQMELMEYKTGKRIIDEEGVESINDMFHENAMLQT 438

  Fly   319 -----KLRLNPMQ-------------VARQKQSLAART----------THVF-------RQALCT 348
                 ::|:..||             |:.|...:.||.          .|.:       |..|..
Mouse   439 ENNNLRVRIKAMQETVDALRARITQLVSEQANQVLARAGEGNEEISNMIHSYIKEIEDLRAKLLE 503

  Fly   349 STAIKSNAANHNSIVVPKSKY------------STTKPLSAVLHRTRSEL-GMTPKAKKRARELL 400
            |.|:..|...:.:....:|.|            |:.|....::...:.:| .:..|.||:.:.|.
Mouse   504 SEAVNENLRKNLTRATARSPYFSASSAFSPTILSSDKETIEIIDLAKKDLEKLKRKEKKKKKRLQ 568

  Fly   401 ELEETTLELSSIHIQDSSLSLLGFHSDSDKDRHLMPPPTGQEPRQASSQNSTLMGIVE------- 458
            :|||:..|..|:..:|.       ::|:|:::        :|.:..|.:.:..:.:.|
Mouse   569 KLEESGREERSVAGKDD-------NADTDQEK--------KEEKGVSEKENNELDVEENQEVSDH 618

  Fly   459 -------------------------ETEPKESSKVQQSMVAPTVPTTVRCQLFNTTISPISLRAS 498
                                     ::|..|.:..|..:...|....::.:|.:        ...
Mouse   619 EDEEEEEEDEEEEDDIEGEESSDESDSESDEKANYQADLANITCEIAIKQKLID--------ELE 675

  Fly   499 SSQRELSGIQPMEETVVASPQQPCLRRSVRLASSMRSQNYGAIPK------------------VM 545
            :||:.|..::...|..:...|...  |..:|......||.|::..                  .|
Mouse   676 NSQKRLQTLKKQYEEKLMMLQHKI--RDTQLERDQVLQNLGSVESYSEEKAKKVKCEYEKKLHAM 738

  Fly   546 NLRRSTRLAGIREHATSVVVKNETDAIPHLR----STVQKKRTR 585
            |..........:|||.  ::||::.....|:    ..::.|:|:
Mouse   739 NKELQRLQTAQKEHAR--LLKNQSQYEKQLKKLQQDVMEMKKTK 780

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nod	NP_001285129.1	KISc	8..325	CDD:214526	108/400 (27%)
		KISc	8..318	CDD:276812	106/327 (32%)
		ComEA	540..648	CDD:224472	10/68 (15%)
Kif21a	XP_017171930.1	KISc_KIF4	23..380	CDD:276823	107/330 (32%)
		Smc	<389..787	CDD:224117	58/419 (14%)
		SbcC	<650..>1110	CDD:223496	23/143 (16%)
		WD40	1350..1663	CDD:238121
		WD40 repeat	1401..1460	CDD:293791
		WD40 repeat	1466..1501	CDD:293791
		WD40 repeat	1506..1550	CDD:293791
		WD40 repeat	1558..1591	CDD:293791
		WD40 repeat	1598..1634	CDD:293791
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0244
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900