Protein Alignment nod and Kif11

DIOPT Version :10

• Sequence 1: NP_511125.2
• Gene: nod / 32107
• FlyBaseID: FBgn0002948
• Length: 666
• Species: Drosophila melanogaster
• Sequence 2: NP_034745.1
• Gene: Kif11 / 16551
• MGIID: 1098231
• Length: 1052
• Species: Mus musculus
• Alignment Length: 717
• Identity: 194/717 - (27%)
• Similarity: 314/717 - (43%)
• Gaps: 149/717 - (20%)

  Fly    48 FHFDHAFPATISQDEMYQALILPLVDKLLEGFQCTALAYGQTGTGKSYSM-GMTPPGEILPEH-- 109
            :.||..|.|:..|.::|::::.|::|:::.|:.||..|||||||||:::| |...|.|:....
Mouse    65 YTFDMVFGASTKQIDVYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTMEGERSPNEVYTWEED 129

  Fly   110 --LGILPRALGDIFERVTARQENNKDAIQVYASFIEIYNEKPFDLLGSTPHMPMVAARCQR---- 168
              .||:||.|..|||::|    :|.....|..|.:|||||:.||||..:..   |:.|.|.
Mouse   130 PLAGIIPRTLHQIFEKLT----DNGTEFSVKVSLLEIYNEELFDLLSPSSD---VSERLQMFDDP 187

  Fly   169 ----------CTCLPLHSQADLHHILELGTRNRRVRPTNMNSNSSRSHAI--VTIHVKSKT---- 217
                      ...:.:|::.:::.|||.|...|....|.||:.|||||::  ||||:|..|
Mouse   188 RNKRGVIIKGLEEITVHNKDEVYQILEKGAAKRTTAATLMNAYSSRSHSVFSVTIHMKETTIDGE 252

  Fly   218 ---HHSRMNIVDLAGSEGVRRTGHEGVARQEGVNINLGLLSINKVVMSMAAGHTVIPYRDSVLTT 279
               ...::|:|||||||.:.|:|......:|..|||..||::.:|:.::......||||:|.||.
Mouse   253 ELVKIGKLNLVDLAGSENIGRSGAVDKRAREAGNINQSLLTLGRVITALVERTPHIPYRESKLTR 317

  Fly   280 VLQASLTAQSYLTFLACISPHQCDLSETLSTLRFGTSAKKLRLNP----------------MQVA 328
            :||.||..::..:.:|.|||...:|.||||||.:...||.:...|                .::.
Mouse   318 ILQDSLGGRTRTSIIATISPASFNLEETLSTLEYAHRAKNIMNKPEVNQKLTKKALIKEYTEEIE 382

  Fly   329 RQKQSLAARTTHVFRQALCTSTAIKSNAANHNSIVVPKSKYSTTKPLSAVLHRTRS---ELGMTP 390
            |.|:.|||.     |:......:.:|..|.:..:.|.:.:........|||....|   ||.|..
Mouse   383 RLKRDLAAA-----REKNGVYISEESFRAMNGKVTVQEEQIVELVEKIAVLEEELSKATELFMDS 442

  Fly   391 KAK-KRARELLELEETTLELSSIHIQDSSLSLL-------------------------------- 422
            |.: .:.:..|:.:...||.:..|:|::.|.|:
Mouse   443 KNELDQCKSDLQTKTQELETTQKHLQETKLQLVKEEYVSSALERTEKTLHDTASKLLNTVKETTR 507

  Fly   423 ---GFHSDSDKDRHLMPPPTGQEPRQASSQNS------TLMGIVEETEPKESSKVQQSMVAPTVP 478
               |.||..|:.|.:       :...|.:|.|      :|...:||. .|:.|..|::|:  .|.
Mouse   508 AVSGLHSKLDRKRAI-------DEHNAEAQESFGKNLNSLFNNMEEL-IKDGSAKQKAML--DVH 562

  Fly   479 TTVRCQLFNTTISPISLRASSSQRELSGIQPMEETVVASPQQPCLRRSVRLASSMRSQNYGAIPK 543
            .|:...|.::::|.:....:::...|..| |...:...|.....:.....||:..:|...|.|.:
Mouse   563 KTLFGNLMSSSVSALDTITTTALESLVSI-PENVSARVSQISDMILEEQSLAAQSKSVLQGLIDE 626

  Fly   544 -VMNLRRSTRLAGIREHATSVV-VKNETDAIPHL---RSTVQKK---RTRNVKPAPKAWMANNTK 600
             |.:|..|.:..    .|.||| :.|....:.|:   .|||.:|   :.|.:            .
Mouse   627 LVTDLFTSLKTI----VAPSVVSILNINKQLQHIFRASSTVAEKVEDQKREI------------D 675

  Fly   601 CFLDLLNNGNVKQLQEIPGIGPKSAFSLALHRSRLG-CFENLFQVKSLPIWS----GNKW-ERFC 659
            .||.:|.| |:.:|:|      .:..||...:...| ..|:|..:|......    .:.| ||||
Mouse   676 SFLSILCN-NLHELRE------NTVSSLVESQKLCGDLTEDLKTIKETHSQELCQLSSSWAERFC 733

  Fly   660 QI 661
            .:
Mouse   734 AL 735

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nod	NP_511125.2	KISc	8..318	CDD:276812	107/297 (36%)
		ComEA	606..>645	CDD:441164	10/39 (26%)
Kif11	NP_034745.1	KISc_BimC_Eg5	15..367	CDD:276815	110/308 (36%)
		PRK12704	349..>508	CDD:237177	28/163 (17%)
		CCDC158	415..>863	CDD:464943	75/355 (21%)
		Microtub_bind	915..1047	CDD:464048
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	950..1026
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1033..1052