Protein Alignment nod and KIF18B

DIOPT Version :10

• Sequence 1: NP_511125.2
• Gene: nod / 32107
• FlyBaseID: FBgn0002948
• Length: 666
• Species: Drosophila melanogaster
• Sequence 2: XP_011522687.1
• Gene: KIF18B / 146909
• HGNCID: 27102
• Length: 873
• Species: Homo sapiens
• Alignment Length: 751
• Identity: 185/751 - (24%)
• Similarity: 280/751 - (37%)
• Gaps: 203/751 - (27%)

  Fly     7 SAVRIAVREAP--YRQFLGRREPSVVQ-----------------FP----------PWSDGKSLI 42
            |.:::.||..|  .|:...:|.| |||                 ||          |...||.|
Human    15 STLQVVVRVRPPTPRELDSQRRP-VVQVVDERVLVFNPEEPDGGFPGLKWGGTHDGPKKKGKDL- 77

  Fly    43 VDQNEFHFDHAFPATISQDEMYQALILPLVDKLLEGFQCTALAYGQTGTGKSYSMGMTPPGEILP 107
                .|.||..|....:|.:::|.....::|..|:|:.|:..|||.||.||:::| :...|:  |
Human    78 ----TFVFDRVFGEAATQQDVFQHTTHSVLDSFLQGYNCSVFAYGATGAGKTHTM-LGREGD--P 135

  Fly   108 EHLGILPRALGDIFERVTARQENNKDAIQVYASFIEIYNEKPFDLLGSTPHMPM---------VA 163
               ||:.....:::.|:.|||:...  .:|..|:.|:|||:..|||  .|..|:         |.
Human   136 ---GIMYLTTVELYRRLEARQQEKH--FEVLISYQEVYNEQIHDLL--EPKGPLAIREDPDKGVV 193

  Fly   164 ARCQRCTCLPLHSQADLHHILEL---GTRNRRVRPTNMNSNSSRSHAIVTIHVKSK--------- 216
            .:     .|..|..|....:||:   |.|||...||:.|:.|||||||..|.||.:
Human   194 VQ-----GLSFHQPASAEQLLEILTRGNRNRTQHPTDANATSSRSHAIFQIFVKQQDRVPGLTQA 253

  Fly   217 THHSRMNIVDLAGSEGVRRTGHEGVARQEGVNINLGLLSINKVVMSMA---AGHTVIPYRDSVLT 278
            ...::|:::||||||....|..:|...:||.|||..||::..|:.::|   ...|.:|||||.||
Human   254 VQVAKMSLIDLAGSERASSTHAKGERLREGANINRSLLALINVLNALADAKGRKTHVPYRDSKLT 318

  Fly   279 TVLQASLTAQSYLTFLACISPHQCDLSETLSTLRFGTSAKKLRLNPMQVARQKQSLAARTTHVFR 343
            .:|:.||........:|.|||......:|.:||::...||::||:      .|.::.:...|:.:
Human   319 RLLKDSLGGNCRTVMIAAISPSSLTYEDTYNTLKYADRAKEIRLS------LKSNVTSLDCHISQ 377

  Fly   344 QALCTSTAIKSNAANHNSIVV------------PKSKYSTTKPLSAVLHRTRSELGMTPKAKKRA 396
            .|..........||....:.|            |.|..|...|    .|...|.|...|.::...
Human   378 YATICQQLQAEVAALRKKLQVYEGGGQPPPQDLPGSPKSGPPP----EHLPSSPLPPHPPSQPCT 438

  Fly   397 REL----LELEETTLELSSIHIQDSSLSLLGFHSDSDKDRHLMPPPTGQEPRQASSQNSTLMGIV 457
            .||    ..|:|.:|.:.:    ....::.|..||.:           |.|..
Human   439 PELPAGPRALQEESLGMEA----QVERAMEGNSSDQE-----------QSPED------------ 476

  Fly   458 EETEPKESSKVQQSMVAPT--VPTTVRCQLFNTTISPISLRASSSQRELSG-------------- 506
            |:..|.|....|.....||  :|.:.|     .|:.|..:....|.|||.|
Human   477 EDEGPAEEVPTQMPEQNPTHALPESPR-----LTLQPKPVVGHFSARELDGDRSKQLALKVLCVA 536

  Fly   507 -----------------------IQPMEETVVASPQQPCLR-----RSVRLASSMRSQNY----- 538
                                   :|.:.:.....|....||     |...||..:.|::.
Human   537 QRQYSLLQAANLLTPDMITEFETLQQLVQEEKIEPGAEALRTSGLARGAPLAQELCSESIPVPSP 601

  Fly   539 ---------GAIPKVMNLRRSTRLAGIREHATSVVVKNETDAIPHLRSTVQKKRTR------NVK 588
                     |.:.:.|..|.|..|     |...:............|..::|||.|      :..
Human   602 LCPEPPGYTGPVTRTMARRLSGPL-----HTLGIPPGPNCTPAQGSRWPMEKKRRRPSALEADSP 661

  Fly   589 PAPKAWMANNTKCFLDLLNNGNVKQLQEIPGIGPKS 624
            .|||.......:.||..|..|::...|  |..||.:
Human   662 MAPKRGTKRQRQSFLPCLRRGSLPDTQ--PSQGPST 695

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nod	NP_511125.2	KISc	8..318	CDD:276812	111/362 (31%)
		ComEA	606..>645	CDD:441164	6/19 (32%)
KIF18B	XP_011522687.1	KISc_KIP3_like	16..360	CDD:276821	113/364 (31%)
		PHA03247	<606..851	CDD:223021	22/97 (23%)