Protein Alignment nod and KIF19

DIOPT Version :10

• Sequence 1: NP_511125.2
• Gene: nod / 32107
• FlyBaseID: FBgn0002948
• Length: 666
• Species: Drosophila melanogaster
• Sequence 2: XP_016879639.1
• Gene: KIF19 / 124602
• HGNCID: 26735
• Length: 1012
• Species: Homo sapiens
• Alignment Length: 624
• Identity: 149/624 - (23%)
• Similarity: 239/624 - (38%)
• Gaps: 184/624 - (29%)

  Fly     2 EGAKLSAVRIAVREAPYRQFLGRREPSVVQFPPWSDGKSLI----VDQNEFHFDHAFPATISQDE 62
            |||.|.|.::             .|..||...|..|...::    ..:..:.||.||..|.:|:.
Human    28 EGATLIAHKV-------------DEQMVVLMDPMEDPDDILRAHRSREKSYLFDVAFDFTATQEM 79

  Fly    63 MYQALILPLVDKLLEGFQCTALAYGQTGTGKSYSMGMTPPGEILPEHLGILPRALGDIFERVTAR 127
            :|||....|::.::.|:..|..|||.||.||:|:|..|      .:..||..:.|.|:|..:  .
Human    80 VYQATTKSLIEGVISGYNATVFAYGPTGCGKTYTMLGT------DQEPGIYVQTLNDLFRAI--E 136

  Fly   128 QENNKDAIQVYASFIEIYNEKPFDLLGSTPHMPMVAAR--------CQRCTCLPLHSQADLHHIL 184
            :.:|....:|..|::|||||...|||  .|.:..:..|        ....|.:...:..::..:|
Human   137 ETSNDMEYEVSMSYLEIYNEMIRDLL--NPSLGYLELREDSKGVIQVAGITEVSTINAKEIMQLL 199

  Fly   185 ELGTRNRRVRPTNMNSNSSRSHAIVTIHVKSKT---------HHSRMNIVDLAGSEGVRRTGHEG 240
            ..|.|.|...||..|..||||||::.:.|:.::         ...|:.::||||||...:|.:.|
Human   200 MKGNRQRTQEPTAANQTSSRSHAVLQVTVRQRSRVKNILQEVRQGRLFMIDLAGSERASQTQNRG 264

  Fly   241 VARQEGVNINLGLLSINKVV--MSMAAGHTVIPYRDSVLTTVLQASLTA-------------QSY 290
            ...:||.:||..||::...:  :|....:..|.||||.||.:|:...||             .|.
Human   265 QRMKEGAHINRSLLALGNCINALSDKGSNKYINYRDSKLTRLLKVPATAGPGHWAPRDSLGGNSR 329

  Fly   291 LTFLACISPHQCDLSETLSTLRFGTSAKKLRLNPMQVARQKQSLAARTTHVFRQALCTSTAIKSN 355
            ...:|.|||......|:.:||.:...||.::      .|.||:|...:.|:
Human   330 TVMIAHISPASSAFEESRNTLTYAGRAKNIK------TRVKQNLLNVSYHI-------------- 374

  Fly   356 AANHNSIVVP----------KSKYSTTK---------------PLSAVLHRTRSE-LGMTPKAKK 394
             |.:.||:..          |....|.:               .....||..:.| .||....::
Human   375 -AQYTSIIADLRGEIQRLKRKIDEQTGRGQARGRQDRGDIRHIQAEVQLHSGQGEKAGMGQLREQ 438

  Fly   395 RA----------RELLELEETTLEL---SSIHIQDSSLSLLGF---------------------H 425
            .|          |.|||||...:|:   :|.|:    |::.|:                     .
Human   439 LASAFQEQMDVRRRLLELENRAMEVQIDTSRHL----LTIAGWKHEKSRRALKWREEQRKECYAK 499

  Fly   426 SDSDKDRHLMPPPTGQ------EPRQASSQNSTLMGIVEETEPKESSKVQQSMVAPTVPTTVRCQ 484
            .||:||     ..||.      ||.:.::...::..:|:|.:.....|:....         ||:
Human   500 DDSEKD-----SDTGDDQPDILEPPEVAAARESIAALVDEQKQLRKQKLALEQ---------RCR 550

  Fly   485 LFNTTISPISLRASSSQRELSGIQPMEETV---VASPQQ 520
                     .|||...:        :|||:   :.|.:|
Human   551 ---------ELRARGRR--------LEETLPRRIGSEEQ 572

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nod	NP_511125.2	KISc	8..318	CDD:276812	95/345 (28%)
		ComEA	606..>645	CDD:441164
KIF19	XP_016879639.1	KISc_KIP3_like	11..359	CDD:276821	101/353 (29%)
		SMC_N	<374..>574	CDD:481474	43/249 (17%)
		YhaN	512..>670	CDD:443752	15/87 (17%)