Protein Alignment nod and KIF2C

DIOPT Version :9

• Sequence 1: NP_001285129.1
• Gene: nod / 32107
• FlyBaseID: FBgn0002948
• Length: 666
• Species: Drosophila melanogaster
• Sequence 2: NP_006836.2
• Gene: KIF2C / 11004
• HGNCID: 6393
• Length: 725
• Species: Homo sapiens
• Alignment Length: 483
• Identity: 135/483 - (27%)
• Similarity: 218/483 - (45%)
• Gaps: 64/483 - (13%)

  Fly    11 IAVREAPY-RQFLGRREPSVVQFPPWSDGKSLI--------------VDQNEFHFDHAFPATISQ 60
            :.||:.|. :|.|.::|..|:..|    .|.|:              ::...|.||.||..|.|.
Human   261 VCVRKRPLNKQELAKKEIDVISIP----SKCLLLVHEPKLKVDLTKYLENQAFCFDFAFDETASN 321

  Fly    61 DEMYQALILPLVDKLLEGFQCTALAYGQTGTGKSYSMGMTPPGEILPEHLGILPRALGDIFERVT 125
            :.:|:....|||..:.||.:.|..||||||:||:::||....|:......||...|..|:|  :.
Human   322 EVVYRFTARPLVQTIFEGGKATCFAYGQTGSGKTHTMGGDLSGKAQNASKGIYAMASRDVF--LL 384

  Fly   126 ARQE-NNKDAIQVYASFIEIYNEKPFDLLGSTPHMPMVAARCQRCTCLPL-----HSQADLHHIL 184
            ..|. ..|..::||.:|.||||.|.||||.....:.::....|:...:.|     :|..|:..::
Human   385 KNQPCYRKLGLEVYVTFFEIYNGKLFDLLNKKAKLRVLEDGKQQVQVVGLQEHLVNSADDVIKMI 449

  Fly   185 ELGTRNRRVRPTNMNSNSSRSHAIVTIHVKSKTH-HSRMNIVDLAGSE-GVRRTGHEGVARQEGV 247
            ::|:..|....|..|||||||||...|.:::|.. |.:.::|||||:| |...:..:...|.||.
Human   450 DMGSACRTSGQTFANSNSSRSHACFQIILRAKGRMHGKFSLVDLAGNERGADTSSADRQTRMEGA 514

  Fly   248 NINLGLLSINKVVMSMAAGHTVIPYRDSVLTTVLQASLTAQSYLT-FLACISPHQCDLSETLSTL 311
            .||..||::.:.:.::.......|:|:|.||.||:.|...::..| .:|.|||.......||:||
Human   515 EINKSLLALKECIRALGQNKAHTPFRESKLTQVLRDSFIGENSRTCMIATISPGISSCEYTLNTL 579

  Fly   312 RFGTSAKKLRLNPMQVARQKQSLAARTTHVFRQALCTSTAIKSNAANHNSIVVPKSKYSTTKPLS 376
            |:....|:  |:|......:|.:...|..:  :|......|..|        :.|.:...:..:|
Human   580 RYADRVKE--LSPHSGPSGEQLIQMETEEM--EACSNGALIPGN--------LSKEEEELSSQMS 632

  Fly   377 AVLHRTRSELGMTPKAKKRARELLELEETTLELSSIHIQ------------DSSLSLLGFHSDSD 429
            :..........:..||.:..:|:::.....||||.:..|            :|:|:....|..:.
Human   633 SFNEAMTQIRELEEKAMEELKEIIQQGPDWLELSEMTEQPDYDLETFVNKAESALAQQAKHFSAL 697

  Fly   430 KD-----RHLMPPPTGQEPRQASSQNST 452
            :|     |..|     |...|||.|.|:
Human   698 RDVIKALRLAM-----QLEEQASRQISS 720

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nod	NP_001285129.1	KISc	8..325	CDD:214526	107/337 (32%)
		KISc	8..318	CDD:276812	105/330 (32%)
		ComEA	540..648	CDD:224472
KIF2C	NP_006836.2	Globular. /evidence=ECO:0000255	2..254
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	89..116
		Microtubule tip localization signal	98..101
		Negative regulator of microtubule-binding. /evidence=ECO:0000250	207..238
		KISc_KIF2_like	258..586	CDD:276818	105/330 (32%)
		Nuclear localization signal. /evidence=ECO:0000255	415..418		0/2 (0%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3330
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.950