DRSC/TRiP Functional Genomics Resources

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Protein Alignment nod and KIF1C

DIOPT Version :10

Sequence 1:NP_511125.2 Gene:nod / 32107 FlyBaseID:FBgn0002948 Length:666 Species:Drosophila melanogaster
Sequence 2:NP_006603.2 Gene:KIF1C / 10749 HGNCID:6317 Length:1103 Species:Homo sapiens


Alignment Length:638 Identity:164/638 - (25%)
Similarity:264/638 - (41%) Gaps:183/638 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MEGAKLSAVRIAVREAPYRQFLGRREPSVVQFPPWSDGKSLIVDQ----------------NEFH 49
            |.||   :|::|||..|:    ..||.|       .|.|.::..|                ..|.
Human     1 MAGA---SVKVAVRVRPF----NARETS-------QDAKCVVSMQGNTTSIINPKQSKDAPKSFT 51

  Fly    50 FDHAF--------PATISQDEMYQALILPLVDKLLEGFQCTALAYGQTGTGKSYS-MGMTPPGEI 105
            ||:::        |...||.::|:.:...::....||:.....||||||.||||: ||...||: 
Human    52 FDYSYWSHTSTEDPQFASQQQVYRDIGEEMLLHAFEGYNVCIFAYGQTGAGKSYTMMGRQEPGQ- 115

  Fly   106 LPEHLGILPRALGDIFERVTARQENNKDAIQVYASFIEIYNEKPFDLL-----GS--TPHMPMVA 163
                .||:|:...|:|.||:..| :.:.:..|..|::|||.|:..|||     ||  ....|::.
Human   116 ----QGIVPQLCEDLFSRVSENQ-SAQLSYSVEVSYMEIYCERVRDLLNPKSRGSLRVREHPILG 175

  Fly   164 ARCQRCTCLPLHSQADLHHILELGTRNRRVRPTNMNSNSSRSHAIVTIHVKSKTHH--------- 219
            ...|..:.|.:.|.||:..:::.|.:.|.|..||||..||||||:.||....:.|.         
Human   176 PYVQDLSKLAVTSYADIADLMDCGNKARTVAATNMNETSSRSHAVFTIVFTQRCHDQLTGLDSEK 240

  Fly   220 -SRMNIVDLAGSEGVRRTGHEGVARQEGVNINLGLLSINKVVMSMAAGHT------VIPYRDSVL 277
             |::::|||||||....:|..|:..:||.|||..|.::.||:.::|...:      .||||||||
Human   241 VSKISLVDLAGSERADSSGARGMRLKEGANINKSLTTLGKVISALADMQSKKRKSDFIPYRDSVL 305

  Fly   278 TTVLQASLTAQSYLTFLACISPHQCDLSETLSTLRFGTSAKKLRLNPM-------QVARQKQSLA 335
            |.:|:.:|...|....:|.:||...:..|||||||:....|::|.|.:       ::.|:.|...
Human   306 TWLLKENLGGNSRTAMIAALSPADINYEETLSTLRYADRTKQIRCNAIINEDPNARLIRELQEEV 370

  Fly   336 ARTTHVFRQALCTSTAIK-------------------------SNAANHNSIVVPKSKYST---- 371
            ||...:......:::|::                         |:...||..:.|....:|    
Human   371 ARLRELLMAQGLSASALEGLKTEEGSVRGALPAVSSPPAPVSPSSPTTHNGELEPSFSPNTESQI 435

  Fly   372 -----------TKPLSAVLHRT------------------RSELGMTPK---------AKKRARE 398
                       |:.:.|.|:.|                  .:|:|:..:         :.|:...
Human   436 GPEEAMERLQETEKIIAELNETWEEKLRKTEALRMEREALLAEMGVAVREDGGTVGVFSPKKTPH 500

  Fly   399 LLELEETTL--ELSSIHIQDSSLSLLGFHSDSD--------KDRHLM----PPPTGQ-------- 441
            |:.|.|..|  |....||:| .::.:| ..|.|        :::|.:    |.|.|:        
Human   501 LVNLNEDPLMSECLLYHIKD-GVTRVG-QVDMDIKLTGQFIREQHCLFRSIPQPDGEVVVTLEPC 563

  Fly   442 -------------EPRQASSQNSTLMG---IVEETEPKESSKVQQSMVAPTVP 478
                         ||....|.|..:||   :.....| |.:::::....|..|
Human   564 EGAETYVNGKLVTEPLVLKSGNRIVMGKNHVFRFNHP-EQARLERERGVPPPP 615

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nodNP_511125.2 KISc 8..318 CDD:276812 116/357 (32%)
ComEA 606..>645 CDD:441164
KIF1CNP_006603.2 KISc_KIF1A_KIF1B 4..355 CDD:276816 120/370 (32%)
Kinesin_assoc 352..522 CDD:465047 25/170 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 400..438 5/37 (14%)
FHA_KIF1C 498..599 CDD:438780 21/102 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 808..828
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 874..924
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 950..1103
Blue background indicates that the domain is not in the aligned region.

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