DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11695 and ZNF160

DIOPT Version :9

Sequence 1:	NP_572732.1	Gene:	CG11695 / 32106	FlyBaseID:	FBgn0030316	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	NP_001096073.1	Gene:	ZNF160 / 90338	HGNCID:	12948	Length:	818	Species:	Homo sapiens

Alignment Length:	319	Identity:	89/319 - (27%)
Similarity:	137/319 - (42%)	Gaps:	35/319 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   192 RSSNSREMDSYIALHG---RLECCICGGDEQFPNFAEMKRHFRNH---HQSLGYVVC--CQRRYK 248
            |||    :.::.|:|.   ..:|..||     .:|.: |.|.|:|   |.......|  |.:.:.
Human   521 RSS----LTTHQAIHSGEKPYKCIECG-----KSFTQ-KSHLRSHRGIHSGEKPYKCNECGKVFA 575

  Fly   249 KRALYVDHLHMHNDPNYFRCKICSKQLVSRISYDVHMLRFHP--NKDDLSFACDQCSKRFSKQFL 311
            :.:....|..:|.....::|..|.:....|.|     |.||.  :..:..:.|.:|.|.|.....
Human   576 QTSQLARHWRVHTGEKPYKCNDCGRAFSDRSS-----LTFHQAIHTGEKPYKCHECGKVFRHNSY 635

  Fly   312 LTIHSRVHQQERNEQCKHCDRSFRTAVDLRLHMRRTHDPAFVPFICDSCGAKFKTKQNLLVHKRT 376
            |..|.|:|..|:..:|..|.::|....:|..|  :.......|:.|:.||..|....:|..|:||
Human   636 LATHRRIHTGEKPYKCNECGKAFSMHSNLTTH--KVIHTGEKPYKCNQCGKVFTQNSHLANHQRT 698

  Fly   377 VHREGSQLPEVQCQECQVWLSDENSLRKHMYMHLDAASLRQWKCEQCGLEKGSRAKLAAHIRYHH 441
            ...|    ...:|.||....|..:||..|..:|   ...:.:||.:||......|.||.|.|.|.
Human   699 HTGE----KPYRCNECGKAFSVRSSLTTHQAIH---TGKKPYKCNECGKVFTQNAHLANHRRIHT 756

  Fly   442 PKEYHKCTHCAKEFKSSRSLEEHTATHTGQDLYECAFCERTFKNSGNMHKHRRQMHAAQ 500
            .::.::||.|.|.|:...||..|.|.|||:..|:|..|.:.|:.|.|:..|.| ||..:
Human   757 GEKPYRCTECGKAFRVRSSLTTHMAIHTGEKRYKCNECGKVFRQSSNLASHHR-MHTGE 814

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11695	NP_572732.1	zf-AD	2..81	CDD:285071
		C2H2 Zn finger	268..289	CDD:275368	5/20 (25%)
		C2H2 Zn finger	299..319	CDD:275368	7/19 (37%)
		C2H2 Zn finger	327..348	CDD:275368	5/20 (25%)
		C2H2 Zn finger	357..376	CDD:275368	6/18 (33%)
		C2H2 Zn finger	389..409	CDD:275368	7/19 (37%)
		C2H2 Zn finger	420..440	CDD:275368	8/19 (42%)
		C2H2 Zn finger	448..468	CDD:275368	9/19 (47%)
		C2H2 Zn finger	476..494	CDD:275368	6/17 (35%)
ZNF160	NP_001096073.1	KRAB	8..68	CDD:214630
		KRAB	8..47	CDD:279668
		zf-C2H2	257..279	CDD:278523
		C2H2 Zn finger	259..279	CDD:275368
		zf-H2C2_2	271..295	CDD:290200
		C2H2 Zn finger	287..307	CDD:275368
		zf-H2C2_2	299..324	CDD:290200
		C2H2 Zn finger	315..335	CDD:275368
		zf-H2C2_2	327..350	CDD:290200
		C2H2 Zn finger	343..363	CDD:275368
		zf-H2C2_2	355..380	CDD:290200
		COG5048	367..810	CDD:227381	87/313 (28%)
		C2H2 Zn finger	371..391	CDD:275368
		C2H2 Zn finger	399..419	CDD:275368
		zf-H2C2_2	411..436	CDD:290200
		C2H2 Zn finger	427..447	CDD:275368
		zf-H2C2_2	439..463	CDD:290200
		C2H2 Zn finger	455..475	CDD:275368
		C2H2 Zn finger	483..503	CDD:275368
		zf-H2C2_2	496..519	CDD:290200
		C2H2 Zn finger	511..531	CDD:275368	4/13 (31%)
		zf-H2C2_2	523..548	CDD:290200	7/33 (21%)
		C2H2 Zn finger	539..559	CDD:275368	8/25 (32%)
		zf-H2C2_2	551..576	CDD:290200	6/24 (25%)
		C2H2 Zn finger	567..587	CDD:275368	3/19 (16%)
		C2H2 Zn finger	595..615	CDD:275368	7/24 (29%)
		zf-H2C2_2	607..632	CDD:290200	8/29 (28%)
		C2H2 Zn finger	623..643	CDD:275368	7/19 (37%)
		zf-H2C2_2	635..659	CDD:290200	7/23 (30%)
		C2H2 Zn finger	651..671	CDD:275368	5/21 (24%)
		zf-H2C2_2	663..688	CDD:290200	7/26 (27%)
		C2H2 Zn finger	679..699	CDD:275368	7/19 (37%)
		zf-H2C2_2	691..715	CDD:290200	8/27 (30%)
		C2H2 Zn finger	707..727	CDD:275368	7/19 (37%)
		zf-H2C2_2	719..744	CDD:290200	8/27 (30%)
		C2H2 Zn finger	735..755	CDD:275368	8/19 (42%)
		zf-H2C2_2	747..770	CDD:290200	9/22 (41%)
		C2H2 Zn finger	763..783	CDD:275368	9/19 (47%)
		zf-H2C2_2	775..800	CDD:290200	11/24 (46%)
		C2H2 Zn finger	791..811	CDD:275368	7/20 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142340
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840