DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11695 and ZNF30

DIOPT Version :9

Sequence 1:	NP_572732.1	Gene:	CG11695 / 32106	FlyBaseID:	FBgn0030316	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	NP_001092907.1	Gene:	ZNF30 / 90075	HGNCID:	13090	Length:	624	Species:	Homo sapiens

Alignment Length:	331	Identity:	91/331 - (27%)
Similarity:	141/331 - (42%)	Gaps:	50/331 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   201 SYIALHGRL-------ECCICGGDEQFPNFAEMKRH-----------------------FRNHHQ 235
            |.:|.|.|:       ||..||  :.|..:.::.||                       |.:.||
Human   302 SPLAKHQRIHTGEKPYECKECG--KSFTVYGQLTRHQSIHTGEKPFECKECGKAFRLSSFLHAHQ 364

  Fly   236 SLGYVV----C--CQRRYKKRALYVDHLHMHNDPNYFRCKICSKQLVSRISYDVHMLRFHPNKDD 294
            .:...:    |  |.|.:.:.:..|.|..:|.....:.||.|.|.. |..||.|...|.|..  :
Human   365 RIHAEIKPYGCKECGRTFSRASYLVQHGRLHTGEKPYECKECGKAF-STGSYLVQHQRIHTG--E 426

  Fly   295 LSFACDQCSKRFSKQFLLTIHSRVHQQERNEQCKHCDRSFRTAVDLRLHMRRTHDPAFVPFICDS 359
            ..:.|.:|.|.|..:..||:|.|||..|:..:||.|.::||..|.|..| |:.|... .|:.|..
Human   427 KPYECKECGKAFISRHQLTVHQRVHTGEKPYECKECGKAFRVHVHLTQH-RKIHTDV-KPYECKE 489

  Fly   360 CGAKFKTKQNLLVHKRTVHREGSQLPEVQCQECQVWLSDENSLRKHMYMHLDAASLRQWKCEQCG 424
            ||..|.....|:.|.| :| .|.:  ..:|:||....|..:.|.:|..:|   ...:.::|.:||
Human   490 CGKTFSRASYLVQHSR-IH-TGKK--PYECKECGKAFSSGSYLVQHQRIH---TGEKPYECNKCG 547

  Fly   425 LEKGSRAKLAAHIRYHHPKEYHKCTHCAKEFKSSRSLEEHTATHTGQDLYECAFCERTFKNSGNM 489
            .......:|..|...|..::..:|..|.|.|:.:..|.||...|||:..::|..|.:||:.|..:
Human   548 KAFTVYGQLIGHQSVHTGEKPFECKECGKAFRLNSFLTEHQRVHTGEKPFKCKKCGKTFRYSSAL 612

  Fly   490 HKHRRQ 495
            ..|.|:
Human   613 KVHLRK 618

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11695	NP_572732.1	zf-AD	2..81	CDD:285071
		C2H2 Zn finger	268..289	CDD:275368	9/20 (45%)
		C2H2 Zn finger	299..319	CDD:275368	8/19 (42%)
		C2H2 Zn finger	327..348	CDD:275368	9/20 (45%)
		C2H2 Zn finger	357..376	CDD:275368	6/18 (33%)
		C2H2 Zn finger	389..409	CDD:275368	6/19 (32%)
		C2H2 Zn finger	420..440	CDD:275368	5/19 (26%)
		C2H2 Zn finger	448..468	CDD:275368	7/19 (37%)
		C2H2 Zn finger	476..494	CDD:275368	6/17 (35%)
ZNF30	NP_001092907.1	KRAB	14..75	CDD:214630
		KRAB	14..53	CDD:279668
		COG5048	<97..302	CDD:227381	91/331 (27%)
		C2H2 Zn finger	123..143	CDD:275368
		C2H2 Zn finger	151..171	CDD:275368
		C2H2 Zn finger	179..199	CDD:275368
		C2H2 Zn finger	207..227	CDD:275368
		C2H2 Zn finger	235..255	CDD:275368
		COG5048	245..624	CDD:227381	91/331 (27%)
		C2H2 Zn finger	263..283	CDD:275368
		zf-H2C2_2	275..300	CDD:290200
		C2H2 Zn finger	291..311	CDD:275368	4/8 (50%)
		zf-H2C2_2	304..327	CDD:290200	7/24 (29%)
		C2H2 Zn finger	319..339	CDD:275368	6/21 (29%)
		zf-H2C2_2	332..354	CDD:290200	2/21 (10%)
		C2H2 Zn finger	347..367	CDD:275368	3/19 (16%)
		C2H2 Zn finger	375..395	CDD:275368	5/19 (26%)
		C2H2 Zn finger	403..423	CDD:275368	9/20 (45%)
		zf-H2C2_2	415..438	CDD:290200	7/24 (29%)
		C2H2 Zn finger	431..451	CDD:275368	8/19 (42%)
		zf-H2C2_2	444..466	CDD:290200	10/21 (48%)
		C2H2 Zn finger	459..479	CDD:275368	9/20 (45%)
		zf-H2C2_2	471..496	CDD:290200	9/26 (35%)
		C2H2 Zn finger	487..507	CDD:275368	7/20 (35%)
		zf-H2C2_2	499..524	CDD:290200	8/28 (29%)
		C2H2 Zn finger	515..535	CDD:275368	6/19 (32%)
		zf-H2C2_2	527..551	CDD:290200	6/26 (23%)
		C2H2 Zn finger	543..563	CDD:275368	5/19 (26%)
		C2H2 Zn finger	571..591	CDD:275368	7/19 (37%)
		zf-H2C2_2	584..608	CDD:290200	10/23 (43%)
		C2H2 Zn finger	599..619	CDD:275368	7/20 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S7841
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.950