DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11695 and ZNF665

DIOPT Version :9

Sequence 1:	NP_572732.1	Gene:	CG11695 / 32106	FlyBaseID:	FBgn0030316	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	NP_001340387.1	Gene:	ZNF665 / 79788	HGNCID:	25885	Length:	706	Species:	Homo sapiens

Alignment Length:	330	Identity:	87/330 - (26%)
Similarity:	136/330 - (41%)	Gaps:	48/330 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   200 DSYIALHGRL-------ECCICG-----------------GDEQ---------FPNFAEMKRHFR 231
            :||:|.|.|:       :|..||                 |::.         |..::.:..|.|
Human   386 NSYLAKHRRIHTGEKPYKCNECGKAFSMHSNLTKHQIIHTGEKPFKCNECVKVFTQYSHLANHRR 450

  Fly   232 NHHQSLGYVVC--CQRRYKKRALYVDHLHMHNDPNYFRCKICSKQLVSRISYDVHMLRFHPNKDD 294
            .|.....| .|  |.:.:..|:....|..:|.....::|..|.|..........|. ..|  ..:
Human   451 IHTGEKPY-RCDECGKAFSVRSSLTTHQAIHTGEKPYKCNDCGKVFTQNSHLASHR-GIH--SGE 511

  Fly   295 LSFACDQCSKRFSKQFLLTIHSRVHQQERNEQCKHCDRSFRTAVDLRLHMRRTHDPAFVPFICDS 359
            ..:.||:|.|.||:...|..|.|||..|:..:|..|.::|.....|.:|  :|......|:.|:.
Human   512 KPYKCDECGKAFSQTSQLARHWRVHTGEKPYKCNECGKAFSVHSSLTIH--QTIHTGQKPYKCND 574

  Fly   360 CGAKFKTKQNLLVHKRTVHREGSQLPEVQCQECQVWLSDENSLRKHMYMHLDAASLRQWKCEQCG 424
            ||..|:....|.:|:| :|.  .:.| .:|.||....|..::|..|..:|   ...:.:||.:||
Human   575 CGKVFRHNSYLAIHQR-IHT--GEKP-YKCNECGKAFSVHSNLATHQVIH---TGEKPYKCNECG 632

  Fly   425 LEKGSRAKLAAHIRYHHPKEYHKCTHCAKEFKSSRSLEEHTATHTGQDLYECAFCERTFKNSGNM 489
            ......:.||.|.|.|..::.::|..|.|.|....:|..|.|.|||...|:|..|.:.|..:.|:
Human   633 KVFTQNSHLANHRRIHTGEKPYRCNECGKAFSVRSTLTTHMAVHTGDKPYKCNQCGKVFTQNSNL 697

  Fly   490 HKHRR 494
            .||||
Human   698 AKHRR 702

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11695	NP_572732.1	zf-AD	2..81	CDD:285071
		C2H2 Zn finger	268..289	CDD:275368	4/20 (20%)
		C2H2 Zn finger	299..319	CDD:275368	9/19 (47%)
		C2H2 Zn finger	327..348	CDD:275368	5/20 (25%)
		C2H2 Zn finger	357..376	CDD:275368	6/18 (33%)
		C2H2 Zn finger	389..409	CDD:275368	6/19 (32%)
		C2H2 Zn finger	420..440	CDD:275368	7/19 (37%)
		C2H2 Zn finger	448..468	CDD:275368	7/19 (37%)
		C2H2 Zn finger	476..494	CDD:275368	6/17 (35%)
ZNF665	NP_001340387.1	KRAB	37..76	CDD:307490
		COG5048	192..580	CDD:227381	46/199 (23%)
		C2H2 Zn finger	208..228	CDD:275368
		C2H2 Zn finger	236..256	CDD:275368
		C2H2 Zn finger	264..284	CDD:275368
		C2H2 Zn finger	292..312	CDD:275368
		C2H2 Zn finger	320..340	CDD:275368
		C2H2 Zn finger	348..368	CDD:275368
		C2H2 Zn finger	376..396	CDD:275368	5/9 (56%)
		C2H2 Zn finger	404..424	CDD:275368	3/19 (16%)
		C2H2 Zn finger	432..452	CDD:275368	3/19 (16%)
		C2H2 Zn finger	460..480	CDD:275368	4/19 (21%)
		C2H2 Zn finger	488..508	CDD:275368	4/20 (20%)
		C2H2 Zn finger	516..536	CDD:275368	9/19 (47%)
		C2H2 Zn finger	544..564	CDD:275368	6/21 (29%)
		C2H2 Zn finger	572..592	CDD:275368	7/20 (35%)
		zf-H2C2_2	584..608	CDD:316026	8/27 (30%)
		C2H2 Zn finger	600..620	CDD:275368	6/19 (32%)
		zf-H2C2_2	612..637	CDD:316026	7/27 (26%)
		C2H2 Zn finger	628..648	CDD:275368	7/19 (37%)
		zf-H2C2_2	640..664	CDD:316026	8/23 (35%)
		C2H2 Zn finger	656..676	CDD:275368	7/19 (37%)
		zf-H2C2_2	669..693	CDD:316026	10/23 (43%)
		C2H2 Zn finger	684..704	CDD:275368	8/19 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142341
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840