DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11695 and ZNF227

DIOPT Version :9

Sequence 1:	NP_572732.1	Gene:	CG11695 / 32106	FlyBaseID:	FBgn0030316	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	NP_001276095.1	Gene:	ZNF227 / 7770	HGNCID:	13020	Length:	799	Species:	Homo sapiens

Alignment Length:	543	Identity:	132/543 - (24%)
Similarity:	208/543 - (38%)	Gaps:	109/543 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 NLAELIEKHLQLVLLPNDGVSKSLCTQCWQQLADFEQFCAMVMKKQL------------------ 76
            |..|.::| ..|..|.|..:|   |.|.|:|:|.....|......||
Human    96 NKMETLQK-FALKYLSNQELS---CWQIWKQVASELTRCLQGKSSQLLQGDSIQVSENENNIMNP 156

  Fly    77 -GLQQLKME----PF------------------SEDEDADTKAQILCEPEI------------DV 106
             |...:.:|    ||                  |..:..|.|..:....:.            |.
Human   157 KGDSSIYIENQEFPFWRTQHSCGNTYLSESQIQSRGKQIDVKNNLQIHEDFMKKSPFHEHIKTDT 221

  Fly   107 SPAAADNEECNEIDGDASSNSRSSSIRTTSLREMRLP----------SPIRRRMRL-PRAVTAPK 160
            .|......|..:|..|.|:       :...|.|...|          ||   |:.| |...|..|
Human   222 EPKPCKGNEYGKIISDGSN-------QKLPLGEKPHPCGECGRGFSYSP---RLPLHPNVHTGEK 276

  Fly   161 --TQAVKAKARTKTHKAE----ADEDEDAEGEGDPESRSSNSREMDSYIALHGRLECCICGGDEQ 219
              :|:...:...:.|..|    ..|..|...:....|..||.....||       .|..||  :.
Human   277 CFSQSSHLRTHQRIHPGEKLNRCHESGDCFNKSSFHSYQSNHTGEKSY-------RCDSCG--KG 332

  Fly   220 FPNFAEMKRHFRNHHQSLGYVVC--CQRRYKKRALYVDHLHMHNDPNYFRCKICSKQLVSRISYD 282
            |.:...:..|:|.|.....| .|  |.:.:.:.:.:..|..:|.:...::|:.|.|.....::..
Human   333 FSSSTGLIIHYRTHTGEKPY-KCEECGKCFSQSSNFQCHQRVHTEEKPYKCEECGKGFGWSVNLR 396

  Fly   283 VHMLRFHPNKDDLSFACDQCSKRFSKQFLLTIHSRVHQQERNEQCKHCDRSFRTAVDLRLHMRRT 347
            ||. |.|  :.:..:.|::|.|.|::.....||.|||..|:..:|..|.:.|.....|..| ||.
Human   397 VHQ-RVH--RGEKPYKCEECGKGFTQAAHFHIHQRVHTGEKPYKCDVCGKGFSHNSPLICH-RRV 457

  Fly   348 HDPAFVPFICDSCGAKFKTKQNLLVHKRTVHREGSQLPEVQCQECQVWLSDENSLRKHMYMHLDA 412
            | ....|:.|::||..|....:|.:|.| ||.  .:.| .:|:||....|..::|:.|..:|
Human   458 H-TGEKPYKCEACGKGFTRNTDLHIHFR-VHT--GEKP-YKCKECGKGFSQASNLQVHQNVH--- 514

  Fly   413 ASLRQWKCEQCGLEKGSRAKLAAHIRYHHPKEYHKCTHCAKEFKSSRSLEEHTATHTGQDLYECA 477
            ...:::|||.||......:||..|.|.|..::.::|..|.|:|..|.:|:.|...|||:..|:|.
Human   515 TGEKRFKCETCGKGFSQSSKLQTHQRVHTGEKPYRCDVCGKDFSYSSNLKLHQVIHTGEKPYKCE 579

  Fly   478 FCERTFKNSGNMHKHRRQMHAAQ 500
            .|.:.|....|:|.|:| :|:.:
Human   580 ECGKGFSWRSNLHAHQR-VHSGE 601

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11695	NP_572732.1	zf-AD	2..81	CDD:285071	16/69 (23%)
		C2H2 Zn finger	268..289	CDD:275368	6/20 (30%)
		C2H2 Zn finger	299..319	CDD:275368	7/19 (37%)
		C2H2 Zn finger	327..348	CDD:275368	7/20 (35%)
		C2H2 Zn finger	357..376	CDD:275368	6/18 (33%)
		C2H2 Zn finger	389..409	CDD:275368	6/19 (32%)
		C2H2 Zn finger	420..440	CDD:275368	8/19 (42%)
		C2H2 Zn finger	448..468	CDD:275368	7/19 (37%)
		C2H2 Zn finger	476..494	CDD:275368	6/17 (35%)
ZNF227	NP_001276095.1	KRAB	23..83	CDD:214630
		C2H2 Zn finger	326..346	CDD:275368	6/21 (29%)
		zf-H2C2_2	342..363	CDD:316026	6/21 (29%)
		C2H2 Zn finger	354..374	CDD:275368	3/19 (16%)
		C2H2 Zn finger	382..402	CDD:275368	6/20 (30%)
		COG5048	406..779	CDD:227381	65/206 (32%)
		C2H2 Zn finger	410..430	CDD:275368	7/19 (37%)
		C2H2 Zn finger	438..458	CDD:275368	7/20 (35%)
		C2H2 Zn finger	466..486	CDD:275368	7/20 (35%)
		C2H2 Zn finger	494..514	CDD:275368	6/19 (32%)
		C2H2 Zn finger	522..542	CDD:275368	8/19 (42%)
		C2H2 Zn finger	550..570	CDD:275368	7/19 (37%)
		C2H2 Zn finger	578..598	CDD:275368	7/20 (35%)
		C2H2 Zn finger	606..626	CDD:275368
		C2H2 Zn finger	634..654	CDD:275368
		C2H2 Zn finger	662..682	CDD:275368
		C2H2 Zn finger	690..710	CDD:275368
		C2H2 Zn finger	718..738	CDD:275368
		C2H2 Zn finger	746..766	CDD:275368
		C2H2 Zn finger	774..794	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910