Protein Alignment CG11695 and ZFX

DIOPT Version :10

• Sequence 1: NP_572732.1
• Gene: CG11695 / 32106
• FlyBaseID: FBgn0030316
• Length: 544
• Species: Drosophila melanogaster
• Sequence 2: NP_001317256.1
• Gene: ZFX / 7543
• HGNCID: 12869
• Length: 844
• Species: Homo sapiens
• Alignment Length: 643
• Identity: 126/643 - (19%)
• Similarity: 219/643 - (34%)
• Gaps: 208/643 - (32%)

  Fly     6 CLDDA---EHSVPIFDQDDSGDQPVPSNLAELIEKHLQLVL-----LPNDGVS-KSLCTQCWQQL 61
            |..:|   .:.:|:..|||....         .|.:|.:.|     :.:||.| .::.|:.....
Human   224 CASEAVIDANGIPVDQQDDDKGN---------CEDYLMISLDDAGKIEHDGSSGMTMDTESEIDP 279

  Fly    62 ADFEQFCAMVMKKQLGLQQLKMEPFSEDEDADTKAQILCEPEIDVSPAAADNEECNEIDGDASSN 126
            ...:..|..|:|..:    .|.:| .||:...|...:..|||.|......|
Human   280 CKVDGTCPEVIKVYI----FKADP-GEDDLGGTVDIVESEPENDHGVELLD-------------- 325

  Fly   127 SRSSSIRTTSLREMRLPSPIRRRM-------------RLPRAVTAPKTQAVKAKARTKTHKAEAD 178
             ::||||..  ||..:...:....             .:...|...:..|..|.|....|:.:.|
Human   326 -QNSSIRVP--REKMVYMTVNDSQPEDEDLNVAEIADEVYMEVIVGEEDAAAAAAAAAVHEQQMD 387

  Fly   179 EDE---------------DAEGEGDPESRSSNSREMDSYIALHGRL------------------- 209
            ::|               :::|..:....:|....:|....| |||
Human   388 DNEIKTFMPIAWAAAYGNNSDGIENRNGTASALLHIDESAGL-GRLAKQKPKKRRRPDSRQYQTA 451

  Fly   210 -------------ECCICGGDEQFPNFAEMKRHFRNHHQSLG----------------------- 238
                         .|.|||  ::|.:...:|||.:||.:.|.
Human   452 IIIGPDGHPLTVYPCMICG--KKFKSRGFLKRHMKNHPEHLAKKKYRCTDCDYTTNKKISLHNHL 514

  Fly   239 -----------YVVC--CQRRYKKRALYVDHLHMHNDP---NYFRCKICSKQLVSRISYDVHMLR 287
                       .:.|  |.:.:........|..:|.:.   ...:||.|..:...:...:.|:|.
Human   515 ESHKLTSKAEKAIECDECGKHFSHAGALFTHKMVHKEKGANKMHKCKFCEYETAEQGLLNRHLLA 579

  Fly   288 FHPNKDDLSFACDQCSKRFSKQFLLTIHSRVHQQERNEQCKHCDRSFRTAVDLRLHMRRTHDPAF 352
            .|  ..:....|.:|.|.|.....|..|.|:|..|:..||::|:.....:.:|:.|::..|...
Human   580 VH--SKNFPHICVECGKGFRHPSELKKHMRIHTGEKPYQCQYCEYRSADSSNLKTHVKTKHSKE- 641

  Fly   353 VPFICDSCGAKF----KTKQNLLVHKRT-VHREGSQLPEVQCQECQVWLSDENSLRKHM------ 406
            :||.||.|...|    :.:|:.|:|:.: .|         ||..|....|:.:.|::|:
Human   642 MPFKCDICLLTFSDTKEVQQHALIHQESKTH---------QCLHCDHKSSNSSDLKRHIISVHTK 697

  Fly   407 -YMHLDAASLRQWKCEQCGLEKGSR--AKLAAHIRYHHPKEYHKCTH------------------ 450
             |.|         ||:.|  :||..  ::|..|:..|..|:.|:|.|
Human   698 DYPH---------KCDMC--DKGFHRPSELKKHVAAHKGKKMHQCRHCDFKIADPFVLSRHILSV 751

  Fly   451 -----------CAKEFKSSRSLEEHTATHTGQDLYECAFCERTFKNSGNMHKHRRQMH 497
                       |.|.|:....|::|..||:|:.:|:|.:||.:..::....:|...:|
Human   752 HTKDLPFRCKRCRKGFRQQSELKKHMKTHSGRKVYQCEYCEYSTTDASGFKRHVISIH 809

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG11695	NP_572732.1	zf-AD	2..81	CDD:462262	16/83 (19%)
		C2H2 Zn finger	268..289	CDD:275368	5/20 (25%)
		C2H2 Zn finger	299..319	CDD:275368	7/19 (37%)
		SUF4-like	327..>387	CDD:411020	15/64 (23%)
		C2H2 Zn finger	327..348	CDD:411020	4/20 (20%)
		C2H2 Zn finger	327..348	CDD:275368	4/20 (20%)
		C2H2 Zn finger	357..378	CDD:411020	7/25 (28%)
		C2H2 Zn finger	357..376	CDD:275368	7/22 (32%)
		C2H2 Zn finger	389..409	CDD:275368	6/26 (23%)
		C2H2 Zn finger	420..440	CDD:275368	6/21 (29%)
		C2H2 Zn finger	448..468	CDD:275368	7/48 (15%)
		C2H2 Zn finger	476..494	CDD:275368	4/17 (24%)
ZFX	NP_001317256.1	Zfx_Zfy_act	109..449	CDD:461400	46/256 (18%)
		ROS_MUCR	<416..>496	CDD:473244	17/82 (21%)
		C2H2 Zn finger	466..486	CDD:275368	8/21 (38%)
		C2H2 Zn finger	497..521	CDD:275368	0/23 (0%)
		C2H2 Zn finger	529..549	CDD:275368	3/19 (16%)
		COG5048	582..>719	CDD:227381	39/157 (25%)
		C2H2 Zn finger	589..609	CDD:275368	7/19 (37%)
		C2H2 Zn finger	617..636	CDD:275368	4/18 (22%)
		C2H2 Zn finger	674..695	CDD:275368	5/20 (25%)
		C2H2 Zn finger	703..723	CDD:275368	6/21 (29%)
		zf-C2H2	758..780	CDD:395048	5/21 (24%)
		C2H2 Zn finger	760..780	CDD:275368	5/19 (26%)
		zf-H2C2_2	772..796	CDD:463886	9/23 (39%)
		C2H2 Zn finger	788..809	CDD:275368	4/20 (20%)
		C2H2 Zn finger	817..837	CDD:275368