DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11695 and SNAI1

DIOPT Version :9

Sequence 1:	NP_572732.1	Gene:	CG11695 / 32106	FlyBaseID:	FBgn0030316	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	NP_005976.2	Gene:	SNAI1 / 6615	HGNCID:	11128	Length:	264	Species:	Homo sapiens

Alignment Length:	255	Identity:	65/255 - (25%)
Similarity:	94/255 - (36%)	Gaps:	72/255 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   155 AVTAPKTQAVK-AKARTKTHKAEAD----EDEDAEGEGD---------PESRSS---NSREMDSY 202
            :|.||:.|.:. |..|.:.....|:    .|||: |:|.         |.|.||   :|.|.::|
Human    63 SVLAPQAQPIAWASLRLQESPRVAELTSLSDEDS-GKGSQPPSPPSPAPSSFSSTSVSSLEAEAY 126

  Fly   203 IALHGRLECCICGGDEQFPNFAEMKRHFRNHHQSLGYVVCCQRRYKKRALYVDHLHMHNDPNYFR 267
            .|               ||...::.:..    ..|......|.|                 ..|.
Human   127 AA---------------FPGLGQVPKQL----AQLSEAKDLQAR-----------------KAFN 155

  Fly   268 CKICSKQLVSRISYDVHMLRFHPNKDDLSFACDQCSKRFSKQFLLTIHSRVHQQERNEQCKHCDR 332
            ||.|:|:.:|     :..|:.|.....|...|..|.|.||:.:||..|.|.|..|:...|.||.|
Human   156 CKYCNKEYLS-----LGALKMHIRSHTLPCVCGTCGKAFSRPWLLQGHVRTHTGEKPFSCPHCSR 215

  Fly   333 SFRTAVDLRLHMRRTHDPAFVPFICDSCGAKFKTKQNLLVHKRTVHREGSQLPEVQCQEC 392
            :|....:||.|: :||... ..:.|.:|...|....  |:||   |:|..      |..|
Human   216 AFADRSNLRAHL-QTHSDV-KKYQCQACARTFSRMS--LLHK---HQESG------CSGC 262

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11695	NP_572732.1	zf-AD	2..81	CDD:285071
		C2H2 Zn finger	268..289	CDD:275368	6/20 (30%)
		C2H2 Zn finger	299..319	CDD:275368	9/19 (47%)
		C2H2 Zn finger	327..348	CDD:275368	8/20 (40%)
		C2H2 Zn finger	357..376	CDD:275368	6/18 (33%)
		C2H2 Zn finger	389..409	CDD:275368	2/4 (50%)
		C2H2 Zn finger	420..440	CDD:275368
		C2H2 Zn finger	448..468	CDD:275368
		C2H2 Zn finger	476..494	CDD:275368
SNAI1	NP_005976.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..27
		SNAG domain. /evidence=ECO:0000305\|PubMed:20389281, ECO:0000305\|PubMed:21300290	1..20
		Required and sufficient for interaction with KDM1A. /evidence=ECO:0000269\|PubMed:20389281, ECO:0000269\|PubMed:23721412	2..7
		LATS2 binding	10..40
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	86..115		8/29 (28%)
		Destruction motif	95..100		2/5 (40%)
		Required for FBXL14-triggered degradation	120..151		8/49 (16%)
		Required for nuclear localization and interaction with KPNB1, NOTCH1 and PARP1. /evidence=ECO:0000269\|PubMed:21577210, ECO:0000269\|PubMed:22128911	151..264		41/147 (28%)
		C2H2 Zn finger	156..176	CDD:275368	7/24 (29%)
		C2H2 Zn finger	182..202	CDD:275368	9/19 (47%)
		zf-H2C2_2	195..218	CDD:404364	9/22 (41%)
		zf-C2H2	208..230	CDD:395048	8/22 (36%)
		C2H2 Zn finger	210..230	CDD:275368	8/20 (40%)
		C2H2 Zn finger	238..255	CDD:275368	6/21 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24390
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100