DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11695 and topi

DIOPT Version :9

Sequence 1:	NP_572732.1	Gene:	CG11695 / 32106	FlyBaseID:	FBgn0030316	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	NP_649945.1	Gene:	topi / 41199	FlyBaseID:	FBgn0037751	Length:	814	Species:	Drosophila melanogaster

Alignment Length:	699	Identity:	141/699 - (20%)
Similarity:	229/699 - (32%)	Gaps:	232/699 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 SGDQPVPSNLAELIEKHL-----QLVLLPNDGVSKSLCTQCWQQLADFEQFCAMVMKKQLGLQQL 81
            :|..|:|:::  ::|:.|     :.:|...|| .|....|..|.  ....|.|.|...::..:|.
  Fly    61 AGALPMPTDV--VVERTLADPAFKQILQEADG-KKGFDPQAEQM--KIRDFLAGVTSSKMTTEQS 120

  Fly    82 KMEPFSEDEDADTKAQILCEPE--IDVSPAAADNEEC--NEIDGDASSNSRSSSIRTTSLREMRL 142
            .......:..|.|..:|.| |.  :.....|..|..|  ..|:.......:...:.|.|..
  Fly   121 VFHGSRSNSSASTVNRIKC-PTCLVQFDAVAFQNHSCEAKPIEVAVPQQEKPHLVPTVSAP---- 180

  Fly   143 PSPIRRRMRLPRAVTAPKTQAVKAKARTKTHKAEADEDEDAEGEGDPESRSSNSREMDSYIALHG 207
            |:|:.:          |.::.|..:.:.:..:...||.:.....|...||.:         |..|
  Fly   181 PAPLSK----------PASERVIRENQVRLRRYIKDEMKYDLATGIESSRKN---------AAKG 226

  Fly   208 RLECCICGGDEQFPNFAEMKRHFRNHHQSLGYVVCCQRRYKKRALYVDHLHMHNDPNYFRCKICS 272
            ..||.:|  |.:|.:.:.:.||...|...|   :..|...:...:....||:     ..:|..|
  Fly   227 PNECTMC--DRKFVHASGLVRHMEKHALDL---IPSQTSEQPHTIPAAGLHV-----VVKCNSC- 280

  Fly   273 KQLVSRISYD---------VH-----------MLRFHPNK---------------DDLSFA---- 298
                .||.||         :|           |.:...|:               :|.:||
  Fly   281 ----GRIFYDPQVAFRHGLIHDSEHSTMRQSPMTQVPSNRADFNELLLDGEMLIDNDPAFATSNQ 341

  Fly   299 --------------------CDQCSKRFSKQFLLTIHSRVHQQERNEQCKHCDRSFRTAVDLRLH 343
                                |:.|...|:....|.:||..|..||..:|..||....||.:..:|
  Fly   342 NTNPPKKEMFSSLILGSVLQCEFCEYIFADIAELLVHSASHVAERRFECTACDIQMNTAKEASIH 406

  Fly   344 MRRTHDPAFVP-------------FICDSCGAKFKTKQNLLVHKRT-------VHREGSQLPEVQ 388
            .:.  |..|:.             |:|:.|..||.....|..|:.|       ::..|.:| .:.
  Fly   407 FQT--DCIFMREAIRSLNVTLSRYFVCNVCELKFANTDLLQEHRCTSFHYFPRLNENGKKL-LLP 468

  Fly   389 CQECQVWL---------SDENSL----RKHMYMHLDAASLRQWKCEQCGLEKGSRAKLAAHIRYH 440
            |..|.|..         |:|..|    |:....:..|..:||:.|:.||......:.|..|:|:|
  Fly   469 CDFCDVNFEFAHDFLAHSEEKHLNKKKREKETRNTGAGRIRQYLCDICGKSYTQSSHLWQHLRFH 533

  Fly   441 -------------------------HPKEYH---------------------------------- 446
                                     |.::.|
  Fly   534 QGVKPFVCQEENCDRKFTIRPDLNDHIRKCHTGERPYLCLVCGKRFLTGSVFYQHRLIHRGERRY 598

  Fly   447 KCTHCAKEFKSSRSLEEHTATHTGQDLYECAFCERTFKNSGNMHKHRRQMHA------------- 498
            :|..|.|.|..:.:|:.|...|||:..|.|.||.:||:..|:..||.|..|:
  Fly   599 ECEECGKRFYRADALKNHQRIHTGEKPYSCLFCTKTFRQRGDRDKHIRARHSHLDANSRLMMQMQ 663

  Fly   499 ---AQVAALQQQKKVPPSKRKDKGDLLLDVLAAGGKDMSHV-MGAGDMN 543
               .:.||.|:.:...|.::.:      ||  |||...|.| .|:|.|:
  Fly   664 KFQLETAAAQKAQSHNPEQQDN------DV--AGGASTSDVPSGSGFMS 704

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11695	NP_572732.1	zf-AD	2..81	CDD:285071	14/63 (22%)
		C2H2 Zn finger	268..289	CDD:275368	8/40 (20%)
		C2H2 Zn finger	299..319	CDD:275368	6/19 (32%)
		C2H2 Zn finger	327..348	CDD:275368	6/20 (30%)
		C2H2 Zn finger	357..376	CDD:275368	6/18 (33%)
		C2H2 Zn finger	389..409	CDD:275368	7/32 (22%)
		C2H2 Zn finger	420..440	CDD:275368	6/19 (32%)
		C2H2 Zn finger	448..468	CDD:275368	6/19 (32%)
		C2H2 Zn finger	476..494	CDD:275368	8/17 (47%)
topi	NP_649945.1	C2H2 Zn finger	230..250	CDD:275368	6/21 (29%)
		C2H2 Zn finger	277..297	CDD:275368	6/24 (25%)
		C2H2 Zn finger	431..453	CDD:275368	7/21 (33%)
		COG5048	<450..647	CDD:227381	40/197 (20%)
		C2H2 Zn finger	469..490	CDD:275368	5/20 (25%)
		zf-C2H2	511..533	CDD:278523	6/21 (29%)
		C2H2 Zn finger	513..564	CDD:275368	8/50 (16%)
		C2H2 Zn finger	541..561	CDD:275368	1/19 (5%)
		zf-H2C2_2	555..581	CDD:290200	2/25 (8%)
		C2H2 Zn finger	572..592	CDD:275368	0/19 (0%)
		zf-H2C2_2	585..609	CDD:290200	4/23 (17%)
		zf-C2H2	598..620	CDD:278523	6/21 (29%)
		C2H2 Zn finger	600..620	CDD:275368	6/19 (32%)
		zf-H2C2_2	612..637	CDD:290200	11/24 (46%)
		C2H2 Zn finger	628..646	CDD:275368	8/17 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24390
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100