DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11695 and pita

DIOPT Version :9

Sequence 1:	NP_572732.1	Gene:	CG11695 / 32106	FlyBaseID:	FBgn0030316	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	NP_611806.3	Gene:	pita / 37730	FlyBaseID:	FBgn0034878	Length:	683	Species:	Drosophila melanogaster

Alignment Length:	656	Identity:	131/656 - (19%)
Similarity:	220/656 - (33%)	Gaps:	187/656 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 ICRLCLDDAEHSVPIFDQDDSGDQPVPSNLAELIEKHLQLVLLPNDGVSKSLCTQC---WQQLAD 63
            :||.||.: :....||:::..  ....:||...|.....:.:...||:...:|.:|   ::....
  Fly    17 VCRFCLTE-QKLASIFEENPR--VKTTANLPLQIMAITAIEVYAGDGMPGHICLECRLLFEHCYR 78

  Fly    64 FEQFC---------------------------AMVMKKQLGLQQLKMEPFSE------DEDADTK 95
            |:|.|                           .||..|:|.:...|....||      :..|.:.
  Fly    79 FKQMCKRAETLLRQYPLTGNWPSPLEKPRAPMTMVASKKLLVVPAKTAEPSETPKKLLNTMAKSS 143

  Fly    96 AQILCEPEIDVSPAAA------------------------DNEECNEIDGDASSNSRSSSIRTTS 136
            :|::.| ::.|..:|.                        :|:|.:..|..:.....:|.:
  Fly   144 SQVIIE-DVQVLESAMVTPRTVAGSSPVPRRSHAYELKVDNNQELSMDDVQSMLEDMASEL---- 203

  Fly   137 LREMRLP------SPIRRRM----------RLPRAVTAPKTQAVKAKARTKTHKA----EADEDE 181
              |...|      ||::.::          :.|.|...|:....|.|.....:.|    ..|.|.
  Fly   204 --EKEFPDIPQKASPVKPKVLNKSSIRILNKGPAAPVEPRLATPKVKRDDSGNVAIVTEVLDSDL 266

  Fly   182 DAEGEGDPESRSSNSREMDSYIALHGRLECCICGGDEQFPNFAEMKRHFRNHHQSLGYVVC--CQ 244
            ..:.:.||   :.|:.::                ..:.||                    |  |:
  Fly   267 PLDDQDDP---TKNAEKV----------------ATDVFP--------------------CPDCE 292

  Fly   245 RRYKKRALYVDHLHMHNDPNYFRCKICSKQLVSRISYDVHMLRFHPNKDDLSFACDQCSKRFSKQ 309
            |.:..:.|...|...|.....|:|.:|.|...|:  ||:....| .:..:..|.|..|||.|:::
  Fly   293 RSFPLQQLLEIHRLNHTRSRSFQCLLCEKSFFSK--YDLAKHNF-VHTGERPFKCAICSKAFTRK 354

  Fly   310 FLLTIHSRVHQQERNEQCKHCDRSFRTAVDLRLHMRRTHDPAFVPFICDSCGAKFKTKQNLLVHK 374
            .||..|.|.|.......|.:|::.|.:..::..|..|.....  ||.|..|...|..||.|..|:
  Fly   355 ALLHRHERTHTDVPKFICVYCEKPFLSRQEMEKHAERHQKKR--PFQCGVCTKSFAFKQGLERHE 417

  Fly   375 RTVHREGSQLPEVQCQECQVWLSDENSLRKHMYMHLDAASLRQWKCEQCGLEKGSRAKLAAHIRY 439
             |||......|   ||.|:...|..:.|.:|:..|   |..|.:.|:.|.........|:.|:|.
  Fly   418 -TVHSTNLPFP---CQHCERSFSTASKLARHLVAH---AGKRAYPCKYCHKSYMLSHHLSRHLRT 475

  Fly   440 H-----------------------------HPKEYHKCTHCAKEFKSSRSLEEHTATHTGQDLYE 475
            |                             |.....||..|.|:.:...|:|.|...|...:.:.
  Fly   476 HTQTSDASFVCSECKVSYSNYNDLLDHALIHATASLKCPMCRKQIEDIDSVESHMDQHKQSERHA 540

  Fly   476 CAFCERTFKNSGNMHKHRRQMHAAQVAALQQQKKVPPSKRKDKGDLLLDVLAAGGKD--MSHVMG 538
            |.||:..|.....:.:|....|..::...|       ::.:|.|:      ..||.|  ..|:..
  Fly   541 CEFCDHIFLTQKCLQRHIEDDHVVEMEPYQ-------NEFEDDGE------GEGGVDEKEEHLDD 592

  Fly   539 AGDMND 544
            ..||::
  Fly   593 FEDMDN 598

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11695	NP_572732.1	zf-AD	2..81	CDD:285071	20/108 (19%)
		C2H2 Zn finger	268..289	CDD:275368	6/20 (30%)
		C2H2 Zn finger	299..319	CDD:275368	9/19 (47%)
		C2H2 Zn finger	327..348	CDD:275368	5/20 (25%)
		C2H2 Zn finger	357..376	CDD:275368	7/18 (39%)
		C2H2 Zn finger	389..409	CDD:275368	6/19 (32%)
		C2H2 Zn finger	420..440	CDD:275368	5/19 (26%)
		C2H2 Zn finger	448..468	CDD:275368	6/19 (32%)
		C2H2 Zn finger	476..494	CDD:275368	5/17 (29%)
pita	NP_611806.3	zf-AD	17..92	CDD:214871	16/77 (21%)
		COG5048	<281..506	CDD:227381	60/272 (22%)
		C2H2 Zn finger	288..308	CDD:275368	5/19 (26%)
		C2H2 Zn finger	316..336	CDD:275368	7/22 (32%)
		zf-H2C2_2	328..353	CDD:290200	8/25 (32%)
		C2H2 Zn finger	344..364	CDD:275368	9/19 (47%)
		C2H2 Zn finger	372..388	CDD:275370	3/15 (20%)
		C2H2 Zn finger	400..420	CDD:275368	8/20 (40%)
		C2H2 Zn finger	428..448	CDD:275368	6/19 (32%)
		C2H2 Zn finger	456..476	CDD:275368	5/19 (26%)
		C2H2 Zn finger	486..506	CDD:275368	0/19 (0%)
		HARE-HTH	<566..625	CDD:294801	9/46 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24390
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100