DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11695 and CG12391

DIOPT Version :9

Sequence 1:	NP_572732.1	Gene:	CG11695 / 32106	FlyBaseID:	FBgn0030316	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	NP_610639.1	Gene:	CG12391 / 36170	FlyBaseID:	FBgn0033581	Length:	587	Species:	Drosophila melanogaster

Alignment Length:	459	Identity:	98/459 - (21%)
Similarity:	156/459 - (33%)	Gaps:	171/459 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 CRLCLDDAEHSVPIFDQDDSGDQPVPSNLAELIEKHLQLVLLPNDGVSKSLCTQCWQQLADFEQF 67
            ||:|....|.......|.|:    .|:::..:|..::.  :||.|.:.:.:||:|...|.
  Fly   241 CRVCTSKEELVCLFKKQIDA----TPADMLLVICPNVS--ILPKDFMPQFICTKCMGSLT----- 294

  Fly    68 CAMVMKKQLGL--QQLK----------------------MEPFSEDEDADTKAQILCEPEIDVSP 108
            .|:.::|||..  |:|:                      :...|||||           |:|
  Fly   295 IAIQLRKQLETTDQELRKRLSRSKNKVRRPRGYVVIDAPVTDSSEDED-----------ELD--- 345

  Fly   109 AAADNEECNEIDGDASSNSRSSSIRTTSLREMRLPSPIRRRMRLPRAVTAPKTQAVKAKARTKTH 173
               |..:.:::.|..|::|.|:. ...|.:|.:.|.|                   :.:.|.|..
  Fly   346 ---DEFKVSDVAGTTSADSDSAD-SDDSEKEKKKPGP-------------------RGRPRKKPL 387

  Fly   174 KAEADEDEDAEGEGDPESRSSNSREMDSYIALHGRLECCICGGDEQFPNFAEMKRHFRNHHQSLG 238
            |...|.|      |:|.| :...:...|..|..|..||         ||
  Fly   388 KRGTDSD------GEPSS-AQKKKYQPSSTASVGPFEC---------PN---------------- 420

  Fly   239 YVVCCQRRYKKRALYVDHLHMHNDPNYFRCKICSKQLVSRISYDVHMLRFHPNKDDLSFACDQCS 303
                |...:.::..||.|...|                .||.:                ||..|.
  Fly   421 ----CDLTFSRKQSYVLHRKTH----------------ERIEH----------------ACPICG 449

  Fly   304 KRFSKQFLLTIHSRVHQQER-NEQCKHCDRSFRTAVDLRLHMRRTHDPAFVPFICDSCGAKFKTK 367
            |:|..::....|.:.|:||| :.:|:.|.:.||...:|:.||.:.||.....:.|..|...|.|:
  Fly   450 KKFKVEWAYKTHMQRHEQERAHFRCELCPKIFRLRAELKHHMAQRHDEHGFIYECKRCQRTFLTQ 514

  Fly   368 QNLLVHKRTVHREGSQLPEVQCQECQVWLSDENSLRKHMYMHLDAASLRQWKCEQCGLEKGSRAK 432
            |.|..|:           .|.||.     ..|:|:|              .|.||...::.||:|
  Fly   515 QRLQRHQ-----------AVGCQR-----HKEDSVR--------------IKEEQSRFKQESRSK 549

  Fly   433 LAAH 436
            ...|
  Fly   550 DDRH 553

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11695	NP_572732.1	zf-AD	2..81	CDD:285071	20/79 (25%)
		C2H2 Zn finger	268..289	CDD:275368	2/20 (10%)
		C2H2 Zn finger	299..319	CDD:275368	5/19 (26%)
		C2H2 Zn finger	327..348	CDD:275368	7/20 (35%)
		C2H2 Zn finger	357..376	CDD:275368	7/18 (39%)
		C2H2 Zn finger	389..409	CDD:275368	5/19 (26%)
		C2H2 Zn finger	420..440	CDD:275368	6/17 (35%)
		C2H2 Zn finger	448..468	CDD:275368
		C2H2 Zn finger	476..494	CDD:275368
CG12391	NP_610639.1	zf-AD	240..313	CDD:285071	21/82 (26%)
		zf-C2H2	416..438	CDD:278523	8/50 (16%)
		C2H2 Zn finger	418..438	CDD:275368	7/48 (15%)
		zf-C2H2	443..465	CDD:278523	6/37 (16%)
		C2H2 Zn finger	445..465	CDD:275368	5/19 (26%)
		C2H2 Zn finger	474..491	CDD:275368	5/16 (31%)
		C2H2 Zn finger	504..521	CDD:275368	6/16 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24390
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100