DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11695 and CG12942

DIOPT Version :9

Sequence 1:	NP_572732.1	Gene:	CG11695 / 32106	FlyBaseID:	FBgn0030316	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	NP_610628.2	Gene:	CG12942 / 36158	FlyBaseID:	FBgn0033569	Length:	686	Species:	Drosophila melanogaster

Alignment Length:	631	Identity:	124/631 - (19%)
Similarity:	219/631 - (34%)	Gaps:	179/631 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 ICRLC---LDDAEHSVPIFDQDDSGDQPVPSNLAELIEKHLQLVLLPN-DGVSK---SLCTQCWQ 59
            ||..|   |:.|.|.|         :..:.|||.  ::...:.|.||: .|..|   |..|..|.
  Fly    74 ICVRCCRALEVAMHFV---------EMALESNLK--LQAEAKSVKLPSPTGELKRKASNETIPWN 127

  Fly    60 QLA-DFEQFCA---------MVMKKQLGLQQLKMEPFSEDEDADTKAQILC------------EP 102
            |.: :||||..         ::..:...:.:|.::..|..|.|..:.:::.            |.
  Fly   128 QFSQEFEQFVEGYEGPIEENVLYMRGTKVPRLDVDASSSSETAPKEDEVILFDVKYDTNDLEEED 192

  Fly   103 EIDVSPA-------------------------AADN---------------EECNEI-------- 119
            |.|.|.|                         |.:|               |||:.|
  Fly   193 ENDGSDAKNNETFFENSITPGESVMVVSVAEKAVENNNNYNFNNKNGDVTDEECDLIQRALEMTL 257

  Fly   120 -DGDASSNSRSSSIRTTSLRE--MRLPSPIRRRMRLPRAVTA------------PKTQAVKAKAR 169
             |...|.:.::.:...|.|:.  :.:.||:..::....:.|.            ..|.|.:.|..
  Fly   258 NDDGCSQSPKNEASNETQLKSNGIEVSSPLFIKLATTSSTTGNIPILKCNICQYTHTDAEQLKIH 322

  Fly   170 TKT-HKAEADEDEDAEGEGDPES---RSSNS------REMDSYIALHGRLE------------CC 212
            .|: ||....|| |..|....::   |..||      .||..::..|.:::            |.
  Fly   323 YKSIHKISMMED-DIIGLNKNQNFKCRPCNSYETKDRSEMQKHLIDHHKIDGDFEMYCYMQANCP 386

  Fly   213 ICGGDEQFPNFAEMKRHFRNHHQSLGYVV---------CCQRRYKKRALYVDHLHMHNDPNYFRC 268
            .|  |..|.:....::|:...|..:...|         .|.:.:.::|....|.......:...|
  Fly   387 AC--DRIFKDQRSARKHYTRVHTPVQIAVSPTESYACTACDKVFNQKASLHSHQRFCQVKDVVHC 449

  Fly   269 KICSKQLVSRISYDVHMLRFHPNKDDLSFACDQCSKRFSKQFLLTIHSRVHQQERNEQCKHCDRS 333
            ..|.:|..|...|::|:.:.|  ..:....|:.|.:.|.....||:|.:.| .||:.||..|..:
  Fly   450 SFCDQQFNSMRKYELHLQQLH--AVETVHECEICRRSFKSAETLTMHRKRH-SERHYQCGKCSLN 511

  Fly   334 FRTAVDLRLHMRRTHDPAFVPFICDSCGAKFKTKQNLLVHKRTVHREGSQLPEVQCQECQVWLSD 398
            :..:.:||:|..|.|... .|..|.:||.:|:....|..|::..|::.
  Fly   512 YVNSAELRVHYERAHVNE-EPVSCLTCGNQFQNMTLLREHEQRSHQKS----------------- 558

  Fly   399 ENSLRKHMYMHLDAASLRQWKCEQCGLEKGSRAKLAAHIRYHHPKEYHKCTHCAKEFKSSRSLEE 463
                             :.|:||.|..|..:|.:...| :|.|....:||..|..||.......:
  Fly   559 -----------------KVWRCEVCNFETKTRWRRRQH-QYEHMDYPYKCQKCTSEFADRSKFRQ 605

  Fly   464 HTATHTGQDLYECAFCERTFKNSGNMHKH---RRQMHAAQVAALQQ 506
            |:....|.:|.:....|...:..|..::|   .:.:::.::..|.:
  Fly   606 HSKKVHGIELSDEQLAEMFREKKGYTNRHDAFNKSINSLEIPGLTE 651

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11695	NP_572732.1	zf-AD	2..81	CDD:285071	23/95 (24%)
		C2H2 Zn finger	268..289	CDD:275368	6/20 (30%)
		C2H2 Zn finger	299..319	CDD:275368	6/19 (32%)
		C2H2 Zn finger	327..348	CDD:275368	6/20 (30%)
		C2H2 Zn finger	357..376	CDD:275368	6/18 (33%)
		C2H2 Zn finger	389..409	CDD:275368	0/19 (0%)
		C2H2 Zn finger	420..440	CDD:275368	6/19 (32%)
		C2H2 Zn finger	448..468	CDD:275368	5/19 (26%)
		C2H2 Zn finger	476..494	CDD:275368	3/20 (15%)
CG12942	NP_610628.2	zf-AD	22..101	CDD:285071	10/37 (27%)
		C2H2 Zn finger	385..406	CDD:275368	5/22 (23%)
		C2H2 Zn finger	421..470	CDD:275368	9/48 (19%)
		C2H2 Zn finger	449..466	CDD:275371	5/16 (31%)
		C2H2 Zn finger	478..498	CDD:275368	6/19 (32%)
		C2H2 Zn finger	505..526	CDD:275368	6/20 (30%)
		C2H2 Zn finger	534..555	CDD:275368	6/20 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45440048
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930