DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11695 and CG2889

DIOPT Version :9

Sequence 1:	NP_572732.1	Gene:	CG11695 / 32106	FlyBaseID:	FBgn0030316	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	NP_001245615.1	Gene:	CG2889 / 31977	FlyBaseID:	FBgn0030206	Length:	581	Species:	Drosophila melanogaster

Alignment Length:	590	Identity:	173/590 - (29%)
Similarity:	253/590 - (42%)	Gaps:	122/590 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MICRLCLD--DAEHSVPIFDQDDSGDQPVPSNLAELIEKHLQLVLLPNDGVSKSLCTQCWQQLAD 63
            |||||||.  ....:|.:|:.||:   ...:.|.::|.|.|||.:||:||:|.|:||:|.:.|.|
  Fly     1 MICRLCLRCLSPGSAVFLFETDDT---LAETRLVKMIAKFLQLEILPDDGISTSVCTECCEHLED 62

  Fly    64 FEQFCAMVMKKQLGLQ--------------------------QLKMEPFSEDE------------ 90
            |..|..:|.:||..|:                          :|.:.....||
  Fly    63 FNGFWQLVEQKQCSLKKEFLTVDVDCAAMKWTGGVDVDVNIDELPLAAGDMDEKPLDLHNLSLLG 127

  Fly    91 -----DADT-------KAQILCEPEIDVSPA-AADNEECNEIDGDASSNSRSSS----------- 131
                 :.|:       |.|:.||.|.|..|. .|.:.|....:|...|.|.||.
  Fly   128 SVLDVNVDSVEVREPIKEQLPCEEEEDEKPCLQASDSEPEVTEGQPESESDSSDDEPLVRLKSKM 192

  Fly   132 --IRTTSLREMRLPSPI---------------RRRMRLPRAVTAPKTQAVKAKARTKTHKAEADE 179
              .|.||.|..:...||               |||.:.|             ..||.|...|::.
  Fly   193 KPKRKTSARSSKDQGPISLQQELADLLDDGGKRRRRKAP-------------DQRTTTESQESEL 244

  Fly   180 DEDAEGEGDPESRSSNSREMDSYIALHGRLECCICGGDEQFPNFAEMKRHFRNHHQSLGYVVCCQ 244
            ....|.:....||:..::..:..||.:....|.:|  :...|..:|:|.||...||...|:.||.
  Fly   245 QAVLERKPKGCSRAQLAKSYEKAIASYMSASCDLC--EFSAPYLSELKTHFLEVHQREYYIKCCG 307

  Fly   245 RRYKKRALYVDHLHMHNDPNYFRCKICSKQLVSRISYDVHMLRFHPNK-----DDLSFACDQCSK 304
            :.:.:.:..:||:..|.:|..|.|.||.|.|.|:.....|:...| ||     ..|.|.|.:|.:
  Fly   308 KVFTRASKLMDHIRKHINPKLFTCTICKKSLNSQDYLATHIETVH-NKVAQIGKVLKFPCPKCER 371

  Fly   305 RFSKQFLLTIHSRVHQQERNEQ-CKHCDRSFRTAVDLRLHMRRTHDPAFVPFICDSCGAKFKTK- 367
            .||.:..:..|...|..::.|. |:.|.:||.....||.|::..|:... ..:||.||.|||.|
  Fly   372 TFSSERRMANHLAKHDTDQLEHTCEICCKSFANVHRLRRHIQSIHEDLH-RHVCDICGKKFKFKP 435

  Fly   368 ---QNLLVHKRTVHREGSQLPEVQCQECQVWLSDENSLRKHMYMHLDAASLRQWKCEQCGLEKGS 429
               ::||.|      :|...|.|:|..|:|||.:|:|||.|.:.|....::    |..||....|
  Fly   436 SFERHLLEH------QGVVAPAVECPICRVWLKNEHSLRLHRFTHDSTDTV----CPHCGKTCTS 490

  Fly   430 RAKLAAHIRYHHPKEYH-KCTHCAKEFKSSRSLEEHTATHTGQDLYECAFCERTFKNSGNMHKHR 493
            |..|..|::|.|....: :||.|.|.||..|:|:||.|.|||..||.|..|.:..::..||:.|.
  Fly   491 RTALRGHVKYAHKLTTNLQCTFCEKTFKQQRNLDEHMAIHTGLQLYNCPHCPKECRSRSNMYVHI 555

  Fly   494 RQMHA 498
            :|.||
  Fly   556 KQRHA 560

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11695	NP_572732.1	zf-AD	2..81	CDD:285071	33/106 (31%)
		C2H2 Zn finger	268..289	CDD:275368	7/20 (35%)
		C2H2 Zn finger	299..319	CDD:275368	5/19 (26%)
		C2H2 Zn finger	327..348	CDD:275368	7/20 (35%)
		C2H2 Zn finger	357..376	CDD:275368	11/22 (50%)
		C2H2 Zn finger	389..409	CDD:275368	10/19 (53%)
		C2H2 Zn finger	420..440	CDD:275368	7/19 (37%)
		C2H2 Zn finger	448..468	CDD:275368	11/19 (58%)
		C2H2 Zn finger	476..494	CDD:275368	5/17 (29%)
CG2889	NP_001245615.1	zf-AD	2..79	CDD:285071	33/79 (42%)
		C2H2 Zn finger	276..297	CDD:275368	7/22 (32%)
		C2H2 Zn finger	306..323	CDD:275368	3/16 (19%)
		C2H2 Zn finger	331..352	CDD:275368	7/20 (35%)
		C2H2 Zn finger	366..386	CDD:275368	5/19 (26%)
		C2H2 Zn finger	395..416	CDD:275368	7/20 (35%)
		C2H2 Zn finger	424..444	CDD:275368	10/19 (53%)
		C2H2 Zn finger	481..502	CDD:275368	8/20 (40%)
		C2H2 Zn finger	510..530	CDD:275368	11/19 (58%)
		C2H2 Zn finger	538..556	CDD:275368	5/17 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H134721
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG25790
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000909
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.920