DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11695 and ZNF660

DIOPT Version :9

Sequence 1:	NP_572732.1	Gene:	CG11695 / 32106	FlyBaseID:	FBgn0030316	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	NP_775929.2	Gene:	ZNF660 / 285349	HGNCID:	26720	Length:	331	Species:	Homo sapiens

Alignment Length:	333	Identity:	92/333 - (27%)
Similarity:	142/333 - (42%)	Gaps:	41/333 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   164 VKAKARTKTHKAEADEDEDAEGEGDPESRSSNSREMDSYIALHGRLECCICGGDEQFPNFAEMKR 228
            ::.|.|...||...|.....|| .|.||...||             :||....:|:..  ||.::
Human     1 MRRKTRNFKHKTVKDNKVLTEG-SDQESEKDNS-------------QCCDPATNERVQ--AEKRQ 49

  Fly   229 HFRNHHQSLGYVVC--CQRRYKKRALYVDHLHMHNDPNYFRCKICSKQLVSRISYDVHMLRFHPN 291
            :           ||  |.:.:.:.|....|..:|.....::||.|.|......:..||. |.|..
Human    50 Y-----------VCTECGKAFSQSANLTVHERIHTGEKPYKCKECGKAFSHSSNLVVHR-RIHTG 102

  Fly   292 KDDLSFACDQCSKRFSKQFLLTIHSRVHQQERNEQCKHCDRSFRTAVDLRLHMRRTHDPAFVPFI 356
            ..  .:.|.:|.|.||.:..|..|..:|..|:..:||.|.::|..:..|..| .|.| ....|:.
Human   103 LK--PYTCSECGKSFSGKSHLIRHQGIHSGEKTYECKECGKAFSRSSGLISH-HRVH-TGEKPYS 163

  Fly   357 CDSCGAKFKTKQNLLVHKRTVHREGSQLPEVQCQECQVWLSDENSLRKHMYMHLDAASLRQWKCE 421
            |..||..|....||..|:| :|| |.::  .:|:||.........:..|..:|   ...:.::|:
Human   164 CIECGKAFSRSSNLTQHQR-MHR-GKKV--YKCKECGKTCGSNTKIMDHQRIH---TGEKPYECD 221

  Fly   422 QCGLEKGSRAKLAAHIRYHHPKEYHKCTHCAKEFKSSRSLEEHTATHTGQDLYECAFCERTFKNS 486
            :||.....|..|..|.|.|..::.:||..|.|.|.|:|:|.:|...|||:..|:|..|.:||:.:
Human   222 ECGKTFILRKTLNEHQRLHRREKPYKCNECGKAFTSNRNLVDHQRVHTGEKPYKCNECGKTFRQT 286

  Fly   487 GNMHKHRR 494
            ..:..|.|
Human   287 SQVILHLR 294

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11695	NP_572732.1	zf-AD	2..81	CDD:285071
		C2H2 Zn finger	268..289	CDD:275368	7/20 (35%)
		C2H2 Zn finger	299..319	CDD:275368	7/19 (37%)
		C2H2 Zn finger	327..348	CDD:275368	7/20 (35%)
		C2H2 Zn finger	357..376	CDD:275368	7/18 (39%)
		C2H2 Zn finger	389..409	CDD:275368	4/19 (21%)
		C2H2 Zn finger	420..440	CDD:275368	7/19 (37%)
		C2H2 Zn finger	448..468	CDD:275368	8/19 (42%)
		C2H2 Zn finger	476..494	CDD:275368	5/17 (29%)
ZNF660	NP_775929.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..35		12/47 (26%)
		C2H2 Zn finger	52..72	CDD:275368	4/19 (21%)
		zf-H2C2_2	64..89	CDD:316026	6/24 (25%)
		C2H2 Zn finger	80..100	CDD:275368	7/20 (35%)
		COG5048	<107..294	CDD:227381	60/195 (31%)
		C2H2 Zn finger	108..128	CDD:275368	7/19 (37%)
		C2H2 Zn finger	136..156	CDD:275368	7/20 (35%)
		C2H2 Zn finger	164..184	CDD:275368	8/20 (40%)
		C2H2 Zn finger	192..207	CDD:275368	3/14 (21%)
		C2H2 Zn finger	220..240	CDD:275368	7/19 (37%)
		C2H2 Zn finger	248..268	CDD:275368	8/19 (42%)
		C2H2 Zn finger	276..296	CDD:275368	6/19 (32%)
		C2H2 Zn finger	304..324	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24390
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100