DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11695 and Zfy2

DIOPT Version :9

Sequence 1:	NP_572732.1	Gene:	CG11695 / 32106	FlyBaseID:	FBgn0030316	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	NP_033597.2	Gene:	Zfy2 / 22768	MGIID:	99213	Length:	777	Species:	Mus musculus

Alignment Length:	501	Identity:	104/501 - (20%)
Similarity:	187/501 - (37%)	Gaps:	117/501 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    87 SEDEDADTKAQILCEPEIDVSPAAADN----EECNEIDGDASSNSRSSSIRTTSLREMRLPSPIR 147
            :|.|..|.:..|.. |.:::...|:|:    |:...|.||..:...::.   |...|.::.....
Mouse   269 NEAEVTDQRTSIHV-PRVNIYMLASDSQKEEEDTKVIVGDEDAGGTAAD---TPEHEQQMDVSEI 329

  Fly   148 RRMRLPRAVTAP-KTQAVKAKARTKTHKAEADEDEDAEGEGDPESRSSNSREMDS-------YIA 204
            :...||.|.||. ...:.:.:.:..|..|....||....:..|:.:|...:..:|       ::|
Mouse   330 KAAFLPIAWTAAYDNNSDEIEVQNATASAMLHHDESGGLDRVPKQKSKKKKRPESKQYQSAIFVA 394

  Fly   205 LHGR----LECCICGGDEQFPNFAEMKRHFRNHHQSLG----YVVCCQRRYKKRALYVDHLH--- 258
            ..|:    ..|..||  ::|.....:|||.:||.:.|.    :...|.....|:....:|:.
Mouse   395 PDGQTLRVYPCMFCG--KKFKTKRFLKRHIKNHPEYLANKKYHCTECDYSTNKKISLHNHMESHK 457

  Fly   259 -----------------------MHNDPNY---FRCKICSKQLVSRISYDVHMLRFHPNKDDLSF 297
                                   ||.:...   .:||.|..:...:...:.|:|..|..|  ...
Mouse   458 LTIKTEKTTECDDCRKNLSHAGTMHTEKGVNKTCKCKFCDYETAEQTLLNHHLLVVHRKK--FPH 520

  Fly   298 ACDQCSKRFSKQFLLTIHSRVHQQERNEQCKHCDRSFRTAVDLRLHMRRTHDPAFVPFICDSCGA 362
            .|.:|.|.|.....|..|.|||..|:..:|::|:.....:.:|:.|::..|... :|..|..|..
Mouse   521 ICGECGKGFRHPSALKKHIRVHTGEKPYECQYCEYKSADSSNLKTHIKSKHSKE-IPLKCGICLL 584

  Fly   363 KF----KTKQNLLVHKRT-VHREGSQLPEVQCQECQVWLSDENSLRKHM-------YMHLDAASL 415
            .|    :.:|:.::|:.: .|         ||..|....|:.:.|::|:       |.|
Mouse   585 TFSDTKEAQQHAVLHQESRTH---------QCSHCNHKSSNSSDLKRHIISVHTKAYPH------ 634

  Fly   416 RQWKCEQCGLEKGSRAKLAAHIRYHHPKEYHKCTH-----------------------------C 451
               ||:.|.......::|..|:..|..|:.|:|.|                             |
Mouse   635 ---KCDMCSKGFHRPSELKKHVATHKSKKMHQCRHCDFKSPDPFLLSHHILSAHTKNVPFKCKRC 696

  Fly   452 AKEFKSSRSLEEHTATHTGQDLYECAFCERTFKNSGNMHKHRRQMH 497
            .|||:....|:.|..||:.:.:|:|.:||.:.|::....:|...:|
Mouse   697 KKEFQQQCELQTHMKTHSSRKVYQCEYCEYSTKDASGFKRHVISIH 742

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11695	NP_572732.1	zf-AD	2..81	CDD:285071
		C2H2 Zn finger	268..289	CDD:275368	5/20 (25%)
		C2H2 Zn finger	299..319	CDD:275368	7/19 (37%)
		C2H2 Zn finger	327..348	CDD:275368	4/20 (20%)
		C2H2 Zn finger	357..376	CDD:275368	5/22 (23%)
		C2H2 Zn finger	389..409	CDD:275368	6/26 (23%)
		C2H2 Zn finger	420..440	CDD:275368	4/19 (21%)
		C2H2 Zn finger	448..468	CDD:275368	8/48 (17%)
		C2H2 Zn finger	476..494	CDD:275368	5/17 (29%)
Zfy2	NP_033597.2	Zfx_Zfy_act	68..388	CDD:282547	25/122 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	207..234
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	361..389		5/27 (19%)
		Nuclear localization signal. /evidence=ECO:0000255	372..382		2/9 (22%)
		C2H2 Zn finger	405..425	CDD:275370	7/21 (33%)
		C2H2 Zn finger	436..456	CDD:275368	3/19 (16%)
		COG5048	<442..681	CDD:227381	51/259 (20%)
		C2H2 Zn finger	493..514	CDD:275368	5/20 (25%)
		zf-C2H2	520..542	CDD:278523	7/21 (33%)
		C2H2 Zn finger	522..542	CDD:275368	7/19 (37%)
		zf-H2C2_2	534..556	CDD:290200	8/21 (38%)
		C2H2 Zn finger	550..571	CDD:275368	4/20 (20%)
		C2H2 Zn finger	579..599	CDD:275368	4/19 (21%)
		C2H2 Zn finger	607..628	CDD:275368	5/20 (25%)
		C2H2 Zn finger	636..685	CDD:275368	9/48 (19%)
		C2H2 Zn finger	693..713	CDD:275368	6/19 (32%)
		C2H2 Zn finger	721..742	CDD:275368	5/20 (25%)
		C2H2 Zn finger	750..770	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000