DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11695 and Zfy1

DIOPT Version :9

Sequence 1:	NP_572732.1	Gene:	CG11695 / 32106	FlyBaseID:	FBgn0030316	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	NP_033596.3	Gene:	Zfy1 / 22767	MGIID:	99212	Length:	782	Species:	Mus musculus

Alignment Length:	607	Identity:	122/607 - (20%)
Similarity:	218/607 - (35%)	Gaps:	169/607 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 DSGDQPVPSNLAELI--EKHLQLVLLPNDGVSKSLCTQCWQQLADFEQFCAMVMKKQLGLQQLKM 83
            ||...|:.....:.|  |.:|.:.|   |..||          ||.|....:.|..:.|....|:
Mouse   181 DSSGMPLEQQDNDKINCEDYLMMSL---DEPSK----------ADLEGSSEVTMNAESGTDSSKL 232

  Fly    84 EPFSE--------------DE--------DADTK----AQILCE------PEIDVSPAAADN--- 113
            :..|.              ||        :::||    |::..:      |.:::..:|:|:
Mouse   233 DEASPEVIKVCILKADSEVDELGETIHAVESETKNGNEAEVTDQSTSIRVPRVNIYMSASDSQKE 297

  Fly   114 -EECNEIDGDASSNSRSSSIRTTSLREMRLPSPIRRRMRLPRAVTAP-KTQAVKAKARTKTHKAE 176
             |:...|.||..:...::.   |...|.::.....:...||.|.||. ...:.:.:.:..|..|.
Mouse   298 EEDTEVIVGDEDAGGTAAD---TPEHEQQMDVSEIKAAFLPIAWTAAYDNNSDEIEDQNVTASAL 359

  Fly   177 ADEDEDAEGEGDPESRSSNSREMDS-------YIALHGR----LECCICGGDEQFPNFAEMKRHF 230
            .::||....:..|:.:|...:..:|       ::|..|:    ..|..||  ::|.....:|||.
Mouse   360 LNQDESGGLDRVPKQKSKKKKRPESKQYQSAIFVAPDGQTLRVYPCMFCG--KKFKTKRFLKRHT 422

  Fly   231 RNHHQSLG----------------------------------YVVC--CQRRYKKRALYVDHLHM 259
            :||.:.|.                                  ...|  |::..........|..|
Mouse   423 KNHPEYLANKKYHCTECDYSTNKKISLHNHMESHKLTIKTEKTTECDDCRKNLSHAGTLCTHKTM 487

  Fly   260 HNDPNY---FRCKICSKQLVSRISYDVHMLRFHPNKDDLSFACDQCSKRFSKQFLLTIHSRVHQQ 321
            |.:...   .:||.|..:...:...:.|:|..|..|  ....|.:|.|.|.....|..|.|||..
Mouse   488 HTEKGVNKTCKCKFCDYETAEQTLLNHHLLVVHRKK--FPHICGECGKGFRHPSALKKHIRVHTG 550

  Fly   322 ERNEQCKHCDRSFRTAVDLRLHMRRTHDPAFVPFICDSCGAKF----KTKQNLLVHKRT-VHREG 381
            |:..:|::|:.....:.:|:.|::..|... :|..|..|...|    :.:|:.::|:.: .|
Mouse   551 EKPYECQYCEYKSADSSNLKTHIKSKHSKE-IPLKCGICLLTFSDNKEAQQHAVLHQESRTH--- 611

  Fly   382 SQLPEVQCQECQVWLSDENSLRKHM-------YMHLDAASLRQWKCEQCGLEKGSRAKLAAHIRY 439
                  ||..|....|:.:.|::|:       |.|         ||:.|.......::|..|:..
Mouse   612 ------QCSHCNHKSSNSSDLKRHIISVHTKAYPH---------KCDMCSKGFHRPSELKKHVAT 661

  Fly   440 HHPKEYHKCTH-----------------------------CAKEFKSSRSLEEHTATHTGQDLYE 475
            |..|:.|:|.|                             |.|||:....|:.|..||:.:.:|:
Mouse   662 HKSKKMHQCRHCDFNSPDPFLLSHHILSAHTKNVPFKCKRCKKEFQQQCELQTHMKTHSSRKVYQ 726

  Fly   476 CAFCERTFKNSGNMHKHRRQMH 497
            |.:||.:.|::....:|...:|
Mouse   727 CEYCEYSTKDASGFKRHVISIH 748

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11695	NP_572732.1	zf-AD	2..81	CDD:285071	15/61 (25%)
		C2H2 Zn finger	268..289	CDD:275368	5/20 (25%)
		C2H2 Zn finger	299..319	CDD:275368	7/19 (37%)
		C2H2 Zn finger	327..348	CDD:275368	4/20 (20%)
		C2H2 Zn finger	357..376	CDD:275368	5/22 (23%)
		C2H2 Zn finger	389..409	CDD:275368	6/26 (23%)
		C2H2 Zn finger	420..440	CDD:275368	4/19 (21%)
		C2H2 Zn finger	448..468	CDD:275368	8/48 (17%)
		C2H2 Zn finger	476..494	CDD:275368	5/17 (29%)
Zfy1	NP_033596.3	Zfx_Zfy_act	68..388	CDD:282547	43/222 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	211..233		6/21 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	360..386		5/25 (20%)
		Nuclear localization signal. /evidence=ECO:0000255	372..382		2/9 (22%)
		C2H2 Zn finger	405..425	CDD:275370	7/21 (33%)
		C2H2 Zn finger	436..456	CDD:275370	0/19 (0%)
		C2H2 Zn finger	468..488	CDD:275368	3/19 (16%)
		C2H2 Zn finger	499..520	CDD:275368	5/20 (25%)
		COG5048	<513..687	CDD:227381	44/194 (23%)
		zf-C2H2	526..548	CDD:278523	7/21 (33%)
		C2H2 Zn finger	528..548	CDD:275368	7/19 (37%)
		zf-H2C2_2	540..562	CDD:290200	8/21 (38%)
		C2H2 Zn finger	556..577	CDD:275368	4/20 (20%)
		C2H2 Zn finger	585..605	CDD:275368	4/19 (21%)
		C2H2 Zn finger	613..634	CDD:275368	5/20 (25%)
		C2H2 Zn finger	642..691	CDD:275368	9/48 (19%)
		C2H2 Zn finger	699..719	CDD:275368	6/19 (32%)
		zf-H2C2_2	711..735	CDD:290200	8/23 (35%)
		C2H2 Zn finger	727..748	CDD:275368	5/20 (25%)
		C2H2 Zn finger	756..776	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000