DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11695 and lin-13

DIOPT Version :9

Sequence 1:	NP_572732.1	Gene:	CG11695 / 32106	FlyBaseID:	FBgn0030316	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	NP_498678.3	Gene:	lin-13 / 176083	WormBaseID:	WBGene00003002	Length:	2248	Species:	Caenorhabditis elegans

Alignment Length:	771	Identity:	140/771 - (18%)
Similarity:	239/771 - (30%)	Gaps:	299/771 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 CRLCLDDA-------EH-------SVP-------------IFDQDDSG------DQPVPSNLAEL 34
            |:||..||       :|       ..|             :|.:.:||      ..|||::..:
Worm  1310 CQLCSYDAPSQDGMVKHRKTHMRSGCPKEQTKKLFILMKCLFPKHNSGYMRFIEGGPVPASYQD- 1373

  Fly    35 IEKHLQLVLLPNDGVSKSLCTQCWQQ-----LADFEQFCAMVMKKQLGLQQL-----KM-EP--- 85
            :::.....|:.|.|.....|.:.:.|     |...|...:  ..:..|||::     :| ||
Worm  1374 VDRSQMNYLMCNMGTVSPSCHKSYAQAPRTLLEALEGVAS--DSRSGGLQKVVNVTTRMNEPSSS 1436

  Fly    86 ----FSEDEDAD----------------------TKAQILCEPEIDVS---------PAAADNEE 115
                .|:|||.|                      .::.|.||..::.|         |...|.:
Worm  1437 DVIMLSDDEDDDCVVFEKAVPNGVAQGSSTSTPNPESSINCEVRVETSQAGYGGAQQPGYVDED- 1500

  Fly   116 CNEIDGDASSNSRS--------SSIRTTSLREMRLPSPIRRRM-RLPRAVTAPKTQAVKA----- 166
              :.|.:.:...:|        ..:......|:.:.:.:.... .||.:::|.:.:..|.
Worm  1501 --DTDLEVAQGGKSPYGEPVVKEVVDENGDDELAVVAEVENSTGTLPSSISAGREKKFKCQKCSL 1563

  Fly   167 --------KARTKTHKAEADEDEDAEGEGDP-ESRSS-----------NSREMDSYIALHGR--L 209
                    ::..:.|:.:|......|..|.| .:::|           |..:...::|:||.  |
Worm  1564 AFYTNGSLESHMRDHRQDAGAQLCTETYGIPVVTKASWLCRNCCVVFENQPKYQKHMAIHGDTCL 1628

  Fly   210 ECCICGGDEQFPNFAEMKRHFRNHHQ-----SLGYVVCCQRRYKKRALYVDHLHM-HNDPNYFRC 268
            .|..|.|...  |...::.|.::|.:     |.|..:|   .:.......|||.: |....|:.|
Worm  1629 TCIHCSGIAF--NHTAIQNHMKSHEEKKVRYSCGTCLC---TFASDLALFDHLSVAHGVSLYYFC 1688

  Fly   269 KIC--------------------SKQLVSRI-SYDVHMLRFHPNKDDLSF------------ACD 300
            |:|                    :..||.|. :....:|.:.|. |:|.|            :..
Worm  1689 KVCGFGSTSADSVFQHISIHNGHNYSLVQRFGACPAQLLNYDPT-DELEFRSQILNKTIQLVSPS 1752

  Fly   301 QCSKRFSKQFLLTIHSRVHQQERNEQCK--HCDRSFRTAVDLRLHMRRTHDPAFV------PFIC 357
            .||.|          |.:.|.|....||  ||.:::...:....|...|..|.|.      .:..
Worm  1753 DCSHR----------SMLLQCETVVSCKTCHCTQAWFNYMAFNNHSEETGFPQFKNVDLANDYRR 1807

  Fly   358 DSCGAKFKTKQNLL---------------------VHKRTVHRE---------------GSQL-- 384
            |...::...::|.|                     .:|||...|               ||.:
Worm  1808 DFPLSRHLNERNALSMSQFGNAKHGSANHSHGQAQPNKRTFRHEVPYRTAAPRSSLQTNGSSMGS 1872

  Fly   385 ------------------------PEVQCQECQVWLSDE-----NSLRKHM-------------- 406
                                    |..|....::.:::.     |.||.|:
Worm  1873 VTTNGGRVVRPSPPNSMNVTLRRAPPQQAPPRRIVIANSAPNNTNVLRNHVAVTTKCQFKDCDKV 1937

  Fly   407 -------YMHLDAASLRQWKCEQCGLEKGSRAKLAAH-IRYHHPKEYHK---------------- 447
                   .:|...:|...|.|.|||....|...|..| |:.|....|.|
Worm  1938 LHSEFDRQLHSMHSSNSSWFCRQCGHSPKSEIDLFLHYIQVHLKPAYDKHQSNSFKSNVFHLKCP 2002

  Fly   448 ---CTHCAKEFKSSRSLEEHTAT-HTGQDLYECAFCERTFKNSGNMHKHRRQMHAA 499
               ||  :.||:|.::.|:|..| |..:..:|.:.|:..|.:.....|| .|.||:
Worm  2003 IRSCT--SPEFQSPKAFEKHMRTAHAAELPFEASCCDARFASKALCVKH-DQEHAS 2055

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11695	NP_572732.1	zf-AD	2..81	CDD:285071	23/115 (20%)
		C2H2 Zn finger	268..289	CDD:275368	7/41 (17%)
		C2H2 Zn finger	299..319	CDD:275368	4/19 (21%)
		C2H2 Zn finger	327..348	CDD:275368	5/22 (23%)
		C2H2 Zn finger	357..376	CDD:275368	4/39 (10%)
		C2H2 Zn finger	389..409	CDD:275368	4/45 (9%)
		C2H2 Zn finger	420..440	CDD:275368	8/20 (40%)
		C2H2 Zn finger	448..468	CDD:275368	8/20 (40%)
		C2H2 Zn finger	476..494	CDD:275368	4/17 (24%)
lin-13	NP_498678.3	C2H2 Zn finger	961..982	CDD:275368
lin-13	NP_498678.3	C2H2 Zn finger	986..1003	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S7841
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.950