DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11696 and znf574

DIOPT Version :9

Sequence 1:	NP_572731.1	Gene:	CG11696 / 32104	FlyBaseID:	FBgn0030314	Length:	664	Species:	Drosophila melanogaster
Sequence 2:	NP_001164307.1	Gene:	znf574 / 798589	ZFINID:	ZDB-GENE-100922-259	Length:	1009	Species:	Danio rerio

Alignment Length:	975	Identity:	174/975 - (17%)
Similarity:	303/975 - (31%)	Gaps:	396/975 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 STCLCNRCWRQLAEIEQFCSMVAEKQRSLHRSLQ-LKTELP--------ELPELTEPEPALVVWN 105
            |..:|..|:|:...:|:   ::|.:......:.| |..|.|        .||::......:....
Zfish     5 SVYMCFPCYREFPTLEE---VLAHQMTCTAENPQLLPNETPVEAAAAAAGLPQVAMQAVTVPQIQ 66

  Fly   106 TESPIE---------------PKLSYEGDDIKDHILCEPVIDALS----------------AGDE 139
            |::.::               |::.|:..|      ||.:.||||                ||::
Zfish    67 TQTAVDLSSLLQQKKTIQADAPRVLYQCAD------CEVLFDALSLWQQHRKMGCCLETEPAGEQ 125

  Fly   140 KDSDYGDTFEPDFEP-------ESQPDEEEEPEPDPVK--------------------------- 170
            .    |:|:|...:|       |:...|:..||...||
Zfish   126 T----GETYEAVAQPQPSQKENENAVQEQNTPEQTQVKEVVEIRFESVSQGSVEVAGKVAAPATS 186

  Fly   171 ------------------------------PRPRGRPRKTA----------LQQTHQIIKRKYEK 195
                                          |..|.|.:|.|          ..|:..::......
Zfish   187 EEEESSNSVSKEASATHEASSVETSAEASSPATRRRGQKKAKPPSSLLCVECGQSFSLVPELVTH 251

  Fly   196 RKQQNKAK--------------ITELSLRESRARQREL----KRSSAG----------------- 225
            |:.|:..|              .|.|.|...|..:.|:    |::|:|
Zfish   252 RRTQHGLKDAIHRCAVCGEGFLNTTLFLYHRRQHRSEVEEEPKQASSGIPQISTAMLEAPGEGLL 316

  Fly   226 ----AEDDQDGDEDEEDEEDVGGELTPDAD-----EQPKPRGKRGRP----------KTKKLV-- 269
                |.:.|...|....|:.:  ..||.|.     |..:.||....|          ||::::
Zfish   317 LLATAGEGQSLMEVTTLEQTI--TETPVAQVEVELEGNEMRGTEQEPMVEGAEILVEKTEEMLEE 379

  Fly   270 -TADDNDDTSEVPVKR----------SSIKEMDDYIAANVKLD------CAICAAPLEDFNDLKR 317
             .|.|.:...|:.:::          .:.:|:.|.:.:|...:      |..|.:...:..:|.:
Zfish   380 HEAPDQEVKMELVIEKVEGNVQMEKIGADEEIQDAVESNASENTSTAFLCHQCGSVFSNDQELAK 444

  Fly   318 HFRVEH----------DC--------------------------TGYVK---------------- 330
            |.:.||          ||                          |..||
Zfish   445 HRKAEHGLEAALHTCGDCGAKFMSTTQFLYHRRQHKNTTAGHLVTAEVKSRLYTTAASATGAAAA 509

  Fly   331 -----------------------C--CNNRYKKRTLYVDHLHCHKDPQYFSCQSCRKNFLNRNSQ 370
                                   |  |...:.:|:...:|:..|...:.|:|:.|:|:|.:..:.
Zfish   510 ADGGLEAPAKLSREWSRTALPHECPHCGQGFTRRSRLREHVFQHTGEKLFNCKICKKSFPSPANL 574

  Fly   371 VMHMLRFHSQQQELVHQCAICEARFAKKFLLTMHLKGH-KGTE-----------------RPEVC 417
            :.|.| .|...:  ::.|.||:.||.:...|..|:..| :|.:                 |..:|
Zfish   575 LRHSL-IHGGSR--IYSCPICDKRFFQPTSLKRHMMTHQEGVQERRTRGRGKGRGPSSDGRLHIC 636

  Fly   418 DTCSKTFRTKFELSAHVKRMHAADFTPIICDICGTHFRSKANFLIHKKALHPD------------ 470
            ..|..:|:.:.:|.:| :.:|.:.  |..|.:||..|..:....:| ..:|.|
Zfish   637 PECPASFKLEAQLKSH-RLLHTSH--PFPCSVCGEAFIRRKELDLH-SLIHQDKEPKMCPNCGSQ 697

  Fly   471 -----------------------------GPV-AEVQCTLCGRWLRDERSLRKHLARHDDRDGDT 505
                                         |.| .:::|.:||.....:..|..|...|   .|.|
Zfish   698 FLNQTVLDTHLQRCTGEQTGQRKYKGQGRGKVGGQLECDMCGHRCVTQDGLDLHRLSH---TGQT 759

  Fly   506 KYRCLL--CNAEKSSRAALSSHMRYH--------HSAKRHKCSLCDKEFKLPRALAEHMATHTGI 560
            ..||.|  |....:|.|||..|:..|        ::.:|..|..|.|||........||.|||..
Zfish   760 PLRCPLAPCRRRFASSAALGEHLVAHCCGALGKRNAPRRFTCEFCGKEFAYASTFTVHMRTHTNE 824

  Fly   561 DLYQCQFCTRTFKSHANMHNHKKKMHPND-----WV-RKYSQPSSSITSTA-------------A 606
            ..::|..|.:.|:...::.:| :::|..:     || .|....::.:|..|             .
Zfish   825 RPFECAQCGKRFRQLPHLQDH-ERIHSGERPFTCWVCGKSFSVAARLTEHARVHSGERPYVCPRC 888

  Fly   607 PLA---HPN-------HPNQPAPPAAAPTNLAGHMLPPLGGIAKSLIEIPDTEGFDFGSNSSVCP 661
            |.|   .||       |.|.|..|.|  .|:...     ....::::.:.::......|:|||.|
Zfish   889 PTAFRSRPNLDKHMRIHANDPVDPTA--QNVMDD-----DAAVQTILLVQESASSSPSSSSSVMP 946

Fly 662 661
Zfish 947 946

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11696	NP_572731.1	zf-AD	2..78	CDD:285071	6/27 (22%)
		C2H2 Zn finger	332..349	CDD:275368	3/16 (19%)
		C2H2 Zn finger	357..378	CDD:275368	6/20 (30%)
		C2H2 Zn finger	388..408	CDD:275368	7/19 (37%)
		C2H2 Zn finger	417..438	CDD:275368	5/20 (25%)
		C2H2 Zn finger	447..465	CDD:275368	5/17 (29%)
		C2H2 Zn finger	478..498	CDD:275368	5/19 (26%)
		C2H2 Zn finger	509..529	CDD:275368	8/21 (38%)
		C2H2 Zn finger	537..557	CDD:275368	7/19 (37%)
		C2H2 Zn finger	565..583	CDD:275368	4/17 (24%)
znf574	NP_001164307.1	PRK10905	<56..>233	CDD:236792	27/186 (15%)
		C2H2 Zn finger	235..255	CDD:275370	2/19 (11%)
		C2H2 Zn finger	265..285	CDD:275370	4/19 (21%)
		CpXC	429..>480	CDD:291051	8/50 (16%)
		C2H2 Zn finger	429..450	CDD:275368	4/20 (20%)
		C2H2 Zn finger	459..479	CDD:275368	2/19 (11%)
		C2H2 Zn finger	533..553	CDD:275368	4/19 (21%)
		COG5048	557..905	CDD:227381	77/358 (22%)
		C2H2 Zn finger	561..581	CDD:275368	6/20 (30%)
		zf-C2H2	587..609	CDD:278523	7/21 (33%)
		C2H2 Zn finger	589..609	CDD:275368	7/19 (37%)
		C2H2 Zn finger	636..656	CDD:275368	5/20 (25%)
		C2H2 Zn finger	663..683	CDD:275368	5/20 (25%)
		C2H2 Zn finger	691..708	CDD:275368	0/16 (0%)
		C2H2 Zn finger	735..755	CDD:275370	5/19 (26%)
		C2H2 Zn finger	763..785	CDD:275368	8/21 (38%)
		zf-C2H2	799..821	CDD:278523	7/21 (33%)
		C2H2 Zn finger	801..821	CDD:275368	7/19 (37%)
		zf-H2C2_2	816..838	CDD:290200	8/21 (38%)
		C2H2 Zn finger	829..849	CDD:275368	4/20 (20%)
		zf-H2C2_2	841..865	CDD:290200	5/24 (21%)
		C2H2 Zn finger	857..877	CDD:275368	5/19 (26%)
		C2H2 Zn finger	885..905	CDD:275368	4/19 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591931
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840