Protein Alignment CG11696 and ZFY

DIOPT Version :10

• Sequence 1: NP_572731.1
• Gene: CG11696 / 32104
• FlyBaseID: FBgn0030314
• Length: 664
• Species: Drosophila melanogaster
• Sequence 2: NP_003402.2
• Gene: ZFY / 7544
• HGNCID: 12870
• Length: 801
• Species: Homo sapiens
• Alignment Length: 637
• Identity: 145/637 - (22%)
• Similarity: 236/637 - (37%)
• Gaps: 132/637 - (20%)

  Fly    42 VLAENDVVSTCLCNRCWRQLAEIEQFCSMVAEKQRSLHRSLQLKTEL---PELPELTEPEPALVV 103
            ||| :|:.||.:........:|....|. :...:..:|.|: ::.|:   |...::...|..:..
Human   119 VLA-SDITSTSMSMPEHVLTSESMHVCD-IGHVEHMVHDSV-VEAEIITDPLTSDIVSEEVLVAD 180

  Fly   104 WNTESPIEPK-LSYEGDDIKDHILCEP--VIDALSAGD-EKDSDYGDTFEPDFEPESQPDEEEEP 164
            ...|:.|:.. :|.:..| .|...||.  :|....||. |.|...|.|.  |.|.|..|.:.:..
Human   181 CAPEAVIDASGISVDQQD-NDKASCEDYLMISLDDAGKIEHDGSTGVTI--DAESEMDPCKVDST 242

  Fly   165 EPDPVKPRP-RGRPRKTALQQTHQIIKRKYE-----KRKQQN------KAKITELSLRESRARQR 217
            .|:.:|... :..|.:..|..|..|::.:.|     :...||      :.|:..:::.:|:....
Human   243 CPEVIKVYIFKADPGEDDLGGTVDIVESEPENDHGVELLDQNSSIRVPREKMVYMTVNDSQQEDE 307

  Fly   218 ELK---------------------RSSAGAEDDQDGDEDE------------------------- 236
            :|.                     .::|.|..:|..||||
Human   308 DLNVAEIADEVYMEVIVGEEDAAVAAAAAAVHEQQIDEDEMKTFVPIAWAAAYGNNSDGIENRNG 372

  Fly   237 ------EDEEDVG-GELTPDADEQPKPRGKRGRPKTKKLVTA----DDNDDTSEVPVKRSSIKEM 290
                  ..:|..| |.|   |.::||   |:.||.:::..||    .|....:..|
Human   373 TASALLHIDESAGLGRL---AKQKPK---KKRRPDSRQYQTAIIIGPDGHPLTVYP--------- 422

  Fly   291 DDYIAANVKLDCAICAAPLEDFNDLKRHFR--VEH------DCTGYVKCCNNRYKKRTLYVDHLH 347
                       |.||....:....||||.:  .||      .||   .|.....||.:|: :||.
Human   423 -----------CMICGKKFKSRGFLKRHMKNHPEHLAKKKYHCT---DCDYTTNKKISLH-NHLE 472

  Fly   348 CH----KDPQYFSCQSCRKNFLNRNSQVMHMLRFHSQQQELVHQCAICEARFAKKFLLTMHLKGH 408
            .|    |..:...|..|.|:|.:..:...|.:....:....:|:|..||...|::.||..||...
Human   473 SHKLTSKAEKAIECDECGKHFSHAGALFTHKMVHKEKGANKMHKCKFCEYETAEQGLLNRHLLAV 537

  Fly   409 KGTERPEVCDTCSKTFRTKFELSAHVKRMHAADFTPIICDICGTHFRSKANFLIHKKALHPDGPV 473
            .....|.:|..|.|.||...||..|: |:|..: .|..|..|.......:|...|.|..|  ...
Human   538 HSKNFPHICVECGKGFRHPSELRKHM-RIHTGE-KPYQCQYCEYRSADSSNLKTHIKTKH--SKE 598

  Fly   474 AEVQCTLCGRWLRDERSLRKHLARHDDRDGDTKYRCLLCNAEKSSRAALSSH-MRYHHSAKRHKC 537
            ...:|.:|.....|.:.:::|...|.:   ...::||.|:.:.|:.:.|..| :..|.....|||
Human   599 MPFKCDICLLTFSDTKEVQQHTLVHQE---SKTHQCLHCDHKSSNSSDLKRHVISVHTKDYPHKC 660

  Fly   538 SLCDKEFKLPRALAEHMATHTGIDLYQCQFCTRTFKSHANMHNHKKKMHPND 589
            .:|:|.|..|..|.:|:|.|.|..::||:.|.........:..|...:|..|
Human   661 EMCEKGFHRPSELKKHVAVHKGKKMHQCRHCDFKIADPFVLSRHILSVHTKD 712

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG11696	NP_572731.1	zf-AD	2..81	CDD:462262	9/38 (24%)
		C2H2 Zn finger	332..349	CDD:275368	5/16 (31%)
		C2H2 Zn finger	357..378	CDD:275368	5/20 (25%)
		C2H2 Zn finger	388..408	CDD:275368	8/19 (42%)
		C2H2 Zn finger	417..438	CDD:275368	9/20 (45%)
		C2H2 Zn finger	447..465	CDD:275368	4/17 (24%)
		C2H2 Zn finger	478..498	CDD:275368	4/19 (21%)
		C2H2 Zn finger	509..529	CDD:275368	6/20 (30%)
		zf-H2C2_2	521..545	CDD:463886	8/24 (33%)
		C2H2 Zn finger	537..557	CDD:275368	8/19 (42%)
		C2H2 Zn finger	565..583	CDD:275368	3/17 (18%)
ZFY	NP_003402.2	Zfx_Zfy_act	71..406	CDD:461400	60/298 (20%)
		COG5048	<417..592	CDD:227381	50/200 (25%)
		C2H2 Zn finger	423..443	CDD:275368	7/19 (37%)
		C2H2 Zn finger	454..478	CDD:275368	9/27 (33%)
		C2H2 Zn finger	486..506	CDD:275368	5/19 (26%)
		COG5048	539..>676	CDD:227381	38/143 (27%)
		C2H2 Zn finger	546..566	CDD:275368	9/20 (45%)
		zf-H2C2_2	558..582	CDD:463886	8/25 (32%)
		C2H2 Zn finger	574..593	CDD:275368	4/18 (22%)
		C2H2 Zn finger	603..652	CDD:275368	11/51 (22%)
		C2H2 Zn finger	660..680	CDD:275368	8/19 (42%)
		zf-C2H2	715..737	CDD:395048
		C2H2 Zn finger	717..737	CDD:275368
		zf-H2C2_2	729..753	CDD:463886
		C2H2 Zn finger	745..766	CDD:275368
		C2H2 Zn finger	774..794	CDD:275368