DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11696 and Zfp652

DIOPT Version :9

Sequence 1:	NP_572731.1	Gene:	CG11696 / 32104	FlyBaseID:	FBgn0030314	Length:	664	Species:	Drosophila melanogaster
Sequence 2:	NP_001073676.1	Gene:	Zfp652 / 497984	RGDID:	1566329	Length:	608	Species:	Rattus norvegicus

Alignment Length:	620	Identity:	150/620 - (24%)
Similarity:	226/620 - (36%)	Gaps:	195/620 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 SMVAEKQRS---LHRSLQLKTELPELPELTEPEPALVVW----------NTESPIEPKLSYEGDD 120
            |::|:.:.|   ||       |..|.|...||.....|.          :||.  |.::||:
  Rat    60 SVLADSKMSKPHLH-------ETEEQPYFREPRAVSDVHTVKEDRENSDDTEE--EEEVSYK--- 112

  Fly   121 IKDHILCEPVID----ALSAGDEKDSDYGDTFEPDFEPESQPDEEEEPEPDPVKPR----PRGRP 177
             ::.|:.|..::    .:|.|::..|  ..:.|......|..:||||.|.|.....    ..||.
  Rat   113 -REQIIVEVNLNNQTLNVSKGEKGVS--SQSKETPVLKTSSEEEEEETEEDATDNSSDYGENGRQ 174

  Fly   178 RKTALQQTHQIIKRKYEKRKQQNKAKITELSLRESRARQRELKRSSAGAEDDQDGDEDEEDEEDV 242
            :|               |.||..|.::|          ||..:|:::.|.
  Rat   175 KK---------------KEKQVEKVRVT----------QRRTRRAASVAA--------------- 199

  Fly   243 GGELTPDADEQPKPRGKRGRPKTKKLVTADDNDDTSEVPV-KRSSIKEMDDYIAANVKLDCAICA 306
                   |...|.||..|||.|            ::|:|. |:.:.||.               .
  Rat   200 -------ATTSPTPRTTRGRRK------------SAELPKRKKRAAKEP---------------K 230

  Fly   307 APLEDFNDLKRHFRVEHDCTGYVKCCNNRYKKRTLYVDHLHCHKDPQYFSCQSCRKNFLNRNSQV 371
            ||::.                 .||    .:|.||              :|:.|.:.|..|....
  Rat   231 APVQK-----------------AKC----DEKETL--------------TCEKCPRVFNTRWYLE 260

  Fly   372 MHMLRFHSQQQELVHQCAICEARFAKKFLLTMHLKGHKGT--ERPEVCDTCSKTFRTKFELSAHV 434
            .||...|.:.|       ||: :..|||:|...|..|:.|  |:...|.:|:|:|:..:.|..|:
  Rat   261 KHMNVTHRRMQ-------ICD-KCGKKFVLESELSLHQQTDCEKNIQCVSCNKSFKKLWSLHEHI 317

  Fly   435 KRMHAADFTPIICDICGTHFRSKANFLIHKKALHPDGPVAEVQCTLCGRWLRDERSLRKHLARHD 499
            |.:|........|:||...|.:.|:...|..|...|.|..   |..||:..:...||:.|..:|
  Rat   318 KIVHGYAEKKFACEICEKKFYTMAHVRKHMVAHTKDMPFT---CETCGKSFKRSMSLKVHSLQH- 378

  Fly   500 DRDGDTKYRCLLCNAEKSSRAALSSHMRYHHSAKRHKCSLCDKEFKLPRALAEHMATHTGIDLYQ 564
              .|:..:||..|:.....:..|.|||..|...|:..|..|.|:|.:.:...|||.||||...:.
  Rat   379 --SGEKPFRCENCDERFQYKYQLRSHMSIHIGHKQFMCQWCGKDFNMKQYFDEHMKTHTGEKPFI 441

  Fly   565 CQFCTRTFKSHANMHNHKK-----KMHPND----------WVRKYSQPSSSITS----------- 603
            |:.|.::|.|..||..|::     |.:|.|          .::.:.:....:||
  Rat   442 CEICGKSFTSRPNMKRHRRTHTGEKPYPCDVCGQRFRFSNMLKAHKEKCFRVTSPVNVPPAVQIP 506

  Fly   604 ----TAAPL-AHPNHPNQPAPPAAAPTNLAGHMLP 633
                .|||. |..|.|..|||  |...|..|..||
  Rat   507 LASAPAAPAPAVANTPTSPAP--AVSMNPVGSALP 539

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11696	NP_572731.1	zf-AD	2..78	CDD:285071	3/11 (27%)
		C2H2 Zn finger	332..349	CDD:275368	3/16 (19%)
		C2H2 Zn finger	357..378	CDD:275368	6/20 (30%)
		C2H2 Zn finger	388..408	CDD:275368	7/19 (37%)
		C2H2 Zn finger	417..438	CDD:275368	7/20 (35%)
		C2H2 Zn finger	447..465	CDD:275368	6/17 (35%)
		C2H2 Zn finger	478..498	CDD:275368	6/19 (32%)
		C2H2 Zn finger	509..529	CDD:275368	6/19 (32%)
		C2H2 Zn finger	537..557	CDD:275368	7/19 (37%)
		C2H2 Zn finger	565..583	CDD:275368	7/17 (41%)
Zfp652	NP_001073676.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	60..234		56/262 (21%)
		C2H2 Zn finger	246..265	CDD:275368	6/18 (33%)
		C2H2 Zn finger	273..292	CDD:275368	7/19 (37%)
		C2H2 Zn finger	300..320	CDD:275368	7/19 (37%)
		C2H2 Zn finger	330..350	CDD:275368	6/19 (32%)
		C2H2 Zn finger	358..378	CDD:275368	6/19 (32%)
		SFP1	<380..463	CDD:227516	28/82 (34%)
		C2H2 Zn finger	386..406	CDD:275368	6/19 (32%)
		C2H2 Zn finger	414..434	CDD:275368	7/19 (37%)
		COG5048	438..>487	CDD:227381	10/48 (21%)
		C2H2 Zn finger	442..462	CDD:275368	7/19 (37%)
		C2H2 Zn finger	470..486	CDD:275368	1/15 (7%)
		Mediates interaction with CBFA2T3. /evidence=ECO:0000250	497..608		14/45 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	540..589		150/620 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24390
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100