DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11696 and CG6654

DIOPT Version :9

Sequence 1:	NP_572731.1	Gene:	CG11696 / 32104	FlyBaseID:	FBgn0030314	Length:	664	Species:	Drosophila melanogaster
Sequence 2:	NP_650429.1	Gene:	CG6654 / 41831	FlyBaseID:	FBgn0038301	Length:	639	Species:	Drosophila melanogaster

Alignment Length:	665	Identity:	161/665 - (24%)
Similarity:	237/665 - (35%)	Gaps:	156/665 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 LAELIERHLLLVLAENDVVSTCLCNRCWRQLAEIEQFCSMVAEKQRSLHRSLQLKTELPELPE-- 93
            ||::|..........||.:...:|..|..:::....|........|:| |.| |...|||.|:
  Fly    29 LADMIREFTKTKPRRNDNLPEKVCLSCLSEISNCYTFKIKCENSSRTL-RQL-LPNALPEEPDSK 91

  Fly    94 --------LTEPEPALVVW---------------------NT---ESPIEPKLSYEGD-DIKDHI 125
                    .|:.......|                     ||   :|.|...|.|||: ::.|:.
  Fly    92 VSISCPVATTDQAVQTTSWEPDRCTASVQTDAVTTTDAEQNTSLIKSTISVDLDYEGEGEVFDYE 156

  Fly   126 L-CEPVIDALS--------AGDEKDSDYGDT---FE-PDFEPESQPDE---------EEEPEPDP 168
            | .|||....|        ..|||:..:..|   :| .|.|.|.|..|         :.|.|...
  Fly   157 LPDEPVEKTTSLILQVQGNLKDEKEVVFTQTNVIYEGDDHELEQQIRECNLAIFEGVDNEAEIIT 221

  Fly   169 VKPRPRGRPRKTALQ-------QTHQIIKRKYEKRKQQNKAKITELSLRESRARQRELKRSSAGA 226
            | ..|:...||:|.:       ..||......|:.::..|.::.:.:.|.||.|         |.
  Fly   222 V-TAPQVTTRKSAAKLLTQQENDKHQTPVGSKEEARELEKEQVPQSAKRTSRRR---------GV 276

  Fly   227 EDDQDGDEDEEDEEDVGGELTPDADEQPKPRGKRGRPKTKKLVTADDNDDTSEVPVKRSSIKEMD 291
            .           ::||  ..||.:|.:|.|  |:.|..|::.::| ....|...|...|......
  Fly   277 V-----------KQDV--PATPPSDAEPSP--KQHRLGTQRKLSA-PRAGTVNGPSTTSGAATTP 325

  Fly   292 DYIAANVKLDCAICAAPLEDFNDLKRHFRVEHDCTGYVKCCNNRYKKRTLYVDHLHCHKDPQYFS 356
            :     :|..|..|.|.......|..|.|.:       .|.|..||
  Fly   326 E-----LKYHCDRCNAGFAVEKSLMIHRRQK-------GCINRNYK------------------- 359

  Fly   357 CQSCRKNFLNRNSQVMHMLRFHSQQQELVHQCAICEARFAKKFLLTMHL-KGHKGTERPEVCDTC 420
            |..|.|.|::.:....|      |.....|.|..|..|...|..|:.|: :|||...|.: |:.|
  Fly   360 CNECEKVFVSPDHLAEH------QASHGAHNCPECGIRCDSKEALSKHMVQGHKRNLRNQ-CNIC 417

  Fly   421 SKTFRTKFELSAHVKRMHAADFTPIICDICGTHFRSKANFLIHKKALHPDGPVAEVQCTLCGRWL 485
            .|.|.....|..|: |:|..: .|.:|:|||..|...||...| |..|.:  ....:|.||....
  Fly   418 QKVFTMLSTLRDHM-RIHTGE-KPFVCNICGKSFTQNANLRQH-KLRHSE--TKSFKCELCPHSF 477

  Fly   486 RDERSLRKHLARHDDRDGDTKYRCLLCNAEKSSRAALSSHMRYHHSAKRHKCSLCDKEFKLPRAL 550
            ..:..|..|...|   .||..:.|.:|.|..::..:|:.|.|.|...:.:.|.||...|.....|
  Fly   478 VTKAELTSHARTH---TGDKPFECEVCLARFTTSCSLAKHKRKHTGERPYACDLCPMRFTALNVL 539

  Fly   551 AEHMATHTGIDLYQCQFCTRTFKSHANMHNHKKKMHPNDWVRKYSQPSSSITSTAAPLAHPNHPN 615
            ..|..||||...|.|.||::||....:...| ::.|..:  |.|          ..|:.:....:
  Fly   540 KNHRRTHTGERPYVCPFCSKTFTQRGDCQMH-QRTHQGE--RIY----------ICPVCNEEFKS 591

  Fly   616 QPAPPAAAPTNLAGH 630
            .|    ...::||||
  Fly   592 MP----EMRSHLAGH 602

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11696	NP_572731.1	zf-AD	2..78	CDD:285071	9/46 (20%)
		C2H2 Zn finger	332..349	CDD:275368	3/16 (19%)
		C2H2 Zn finger	357..378	CDD:275368	5/20 (25%)
		C2H2 Zn finger	388..408	CDD:275368	6/20 (30%)
		C2H2 Zn finger	417..438	CDD:275368	7/20 (35%)
		C2H2 Zn finger	447..465	CDD:275368	8/17 (47%)
		C2H2 Zn finger	478..498	CDD:275368	5/19 (26%)
		C2H2 Zn finger	509..529	CDD:275368	6/19 (32%)
		C2H2 Zn finger	537..557	CDD:275368	6/19 (32%)
		C2H2 Zn finger	565..583	CDD:275368	6/17 (35%)
CG6654	NP_650429.1	zf-AD	6..79	CDD:285071	11/50 (22%)
		C2H2 Zn finger	331..354	CDD:275368	6/29 (21%)
		COG5048	<357..570	CDD:227381	69/246 (28%)
		C2H2 Zn finger	360..380	CDD:275368	6/25 (24%)
		C2H2 Zn finger	385..406	CDD:275370	6/20 (30%)
		C2H2 Zn finger	414..434	CDD:275368	7/20 (35%)
		zf-H2C2_2	427..451	CDD:290200	10/25 (40%)
		C2H2 Zn finger	442..490	CDD:275368	15/50 (30%)
		C2H2 Zn finger	470..487	CDD:275368	4/16 (25%)
		zf-H2C2_2	482..507	CDD:290200	8/27 (30%)
		C2H2 Zn finger	498..518	CDD:275368	6/19 (32%)
		zf-H2C2_2	510..534	CDD:290200	7/23 (30%)
		C2H2 Zn finger	526..546	CDD:275368	6/19 (32%)
		zf-H2C2_2	539..563	CDD:290200	12/23 (52%)
		C2H2 Zn finger	554..574	CDD:275368	6/20 (30%)
		C2H2 Zn finger	582..602	CDD:275368	4/23 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24390
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100