DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11696 and ZNF805

DIOPT Version :9

Sequence 1:	NP_572731.1	Gene:	CG11696 / 32104	FlyBaseID:	FBgn0030314	Length:	664	Species:	Drosophila melanogaster
Sequence 2:	NP_001018857.2	Gene:	ZNF805 / 390980	HGNCID:	23272	Length:	627	Species:	Homo sapiens

Alignment Length:	565	Identity:	124/565 - (21%)
Similarity:	193/565 - (34%)	Gaps:	163/565 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   153 EPESQPDEEEEPEPDPVKPRPRGRPRKTALQQTHQIIKRKYEKRKQQNKAKITELSLRESRARQR 217
            |...:|...:|.......|..:|:|:.|                    :....||:|.|..:...
Human    66 EHGQEPWTRKEDLSQGTCPGDKGKPKST--------------------EPTTCELALSEGISFWG 110

  Fly   218 ELKRSSAGAEDDQDGDEDEED--EEDVGGELTPDADEQPKPRGKRGRPKTKKLVTADD------- 273
            :|.:.::|  |.|.|...::|  .|..|..|.|..|.|.:....:..||...|.|||.
Human   111 QLTQGASG--DSQLGQPKDQDGFSEMQGERLRPGLDSQKEKLPGKMSPKHDGLGTADSVCSRIIQ 173

  Fly   274 ---------NDDTSEVPVKRSSIKEMDDYIAANVKLDCAICAAPLEDFND---LKRHFRVE---- 322
                     :|..|....|...|:|.::....|   :|.      :.||.   |.||.|:.
Human   174 DRVSLGDDVHDCDSHGSGKNPVIQEEENIFKCN---ECE------KVFNKKRLLARHERIHSGVK 229

  Fly   323 -HDCTGYVKCCNNRYKKRTLYVDHLHCHKDPQYFSCQSCRKNFLNRNSQVMHMLRFHSQQQELVH 386
             ::||.    |...:.|.|..:.|...|...:.:.|..|.|.| ||.|.:....|.||.::.  :
Human   230 PYECTE----CGKTFSKSTYLLQHHMVHTGEKPYKCMECGKAF-NRKSHLTQHQRIHSGEKP--Y 287

  Fly   387 QCAICEARFAKKFLLTMHLKGHKGTERPEVCDTCSKTFRTK------------------------ 427
            :|:.|...|..:....:|.:.|.| |:|.||..|.|.||.:
Human   288 KCSECGKAFTHRSTFVLHNRSHTG-EKPFVCKECGKAFRDRPGFIRHYIIHSGENPYECFECGKV 351

  Fly   428 -----------------------------------------------FE-------------LSA 432
                                                           ||             |..
Human   352 FKHRSYLMWHQQTHTGEKPYECSECGKAFCESAALIHHYVIHTGEKPFECLECGKAFNHRSYLKR 416

  Fly   433 HVKRMHAADFTPIICDICGTHFRSKANFLIHKKALHPDGPVAEVQCTLCGRWLRDERSLRKHLAR 497
            | :|:|..: .|.:|..||..|...:.|::||:|...:.|   .:|..||:...:...|.:|.:.
Human   417 H-QRIHTGE-KPYVCSECGKAFTHCSTFILHKRAHTGEKP---FECKECGKAFSNRADLIRHFSI 476

  Fly   498 HDDRDGDTKYRCLLCNAEKSSRAALSSHMRYHHSAKRHKCSLCDKEFKLPRALAEHMATHTGIDL 562
            |   .|:..|.|:.|....:.|:.|:.|.|.|...|.::|..|.|.|.....|..|...|||...
Human   477 H---TGEKPYECMECGKAFNRRSGLTRHQRIHSGEKPYECIECGKTFCWSTNLIRHSIIHTGEKP 538

  Fly   563 YQCQFCTRTFK------SHANMHNHKKKMHPNDWVRKYSQPSSSI 601
            |:|..|.:.|.      .|..||..:..:...|..|.::...:|:
Human   539 YECSECGKAFSRSSSLTQHQRMHTGRNPISVTDVGRPFTSGQTSV 583

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11696	NP_572731.1	zf-AD	2..78	CDD:285071
		C2H2 Zn finger	332..349	CDD:275368	4/16 (25%)
		C2H2 Zn finger	357..378	CDD:275368	8/20 (40%)
		C2H2 Zn finger	388..408	CDD:275368	4/19 (21%)
		C2H2 Zn finger	417..438	CDD:275368	10/104 (10%)
		C2H2 Zn finger	447..465	CDD:275368	6/17 (35%)
		C2H2 Zn finger	478..498	CDD:275368	5/19 (26%)
		C2H2 Zn finger	509..529	CDD:275368	6/19 (32%)
		C2H2 Zn finger	537..557	CDD:275368	6/19 (32%)
		C2H2 Zn finger	565..583	CDD:275368	6/23 (26%)
ZNF805	NP_001018857.2	KRAB	13..73	CDD:214630	2/6 (33%)
		KRAB	13..52	CDD:279668
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	71..95		6/43 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	113..162		13/50 (26%)
		COG5048	192..568	CDD:227381	90/400 (23%)
		C2H2 Zn finger	205..225	CDD:275368	8/28 (29%)
		zf-H2C2_2	218..241	CDD:290200	7/26 (27%)
		C2H2 Zn finger	233..253	CDD:275368	6/23 (26%)
		zf-H2C2_2	245..270	CDD:290200	6/25 (24%)
		C2H2 Zn finger	261..281	CDD:275368	8/20 (40%)
		zf-H2C2_2	273..298	CDD:290200	6/26 (23%)
		C2H2 Zn finger	289..309	CDD:275368	4/19 (21%)
		zf-H2C2_2	305..324	CDD:290200	9/19 (47%)
		C2H2 Zn finger	317..337	CDD:275368	5/19 (26%)
		zf-C2H2	343..365	CDD:278523	0/21 (0%)
		C2H2 Zn finger	345..365	CDD:275368	0/19 (0%)
		zf-H2C2_2	357..380	CDD:290200	0/22 (0%)
		C2H2 Zn finger	373..393	CDD:275368	0/19 (0%)
		zf-C2H2	399..421	CDD:278523	5/22 (23%)
		C2H2 Zn finger	401..421	CDD:275368	3/20 (15%)
		zf-H2C2_2	413..438	CDD:290200	9/26 (35%)
		C2H2 Zn finger	429..449	CDD:275368	7/19 (37%)
		zf-H2C2_2	445..466	CDD:290200	7/23 (30%)
		C2H2 Zn finger	457..477	CDD:275368	5/19 (26%)
		zf-H2C2_2	469..494	CDD:290200	7/27 (26%)
		C2H2 Zn finger	485..505	CDD:275368	6/19 (32%)
		zf-H2C2_2	498..520	CDD:290200	8/21 (38%)
		C2H2 Zn finger	513..533	CDD:275368	6/19 (32%)
		zf-H2C2_2	525..550	CDD:290200	9/24 (38%)
		C2H2 Zn finger	541..561	CDD:275368	4/19 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000