DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG11696 and ZNF710

DIOPT Version :9

Sequence 1:NP_572731.1 Gene:CG11696 / 32104 FlyBaseID:FBgn0030314 Length:664 Species:Drosophila melanogaster
Sequence 2:XP_005254963.1 Gene:ZNF710 / 374655 HGNCID:25352 Length:679 Species:Homo sapiens


Alignment Length:628 Identity:143/628 - (22%)
Similarity:217/628 - (34%) Gaps:188/628 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   146 DTFEPDFEPE---SQPDEEEEPEPDPVKPRPRGRPRKTALQQ--THQIIK-----RKYEKRKQQN 200
            :.|.||..||   :...|.|.|.||..:....||    ||::  ..::::     .|:.:||.:.
Human    41 EAFYPDLGPELSGAAMGEPEPPGPDVYQLACNGR----ALEEPAEEEVLEVEAACEKHTRRKTRP 101

  Fly   201 KAK-ITELSLRESRARQRELKRSSAGAEDDQDGDEDEEDEEDVGGELTPDADEQP---------- 254
            ..: :.::...:....::|:...|...:|...|..:...|...||   .||..|.          
Human   102 PVRLVPKVKFEKVEEEEQEVYEVSVPGDDKDAGPAEAPAEAASGG---CDALVQSSAVKMIDLSA 163

  Fly   255 ---KPRGKRGRPKTKKLVTADDNDDTSEVPVKRSSIKEMDDYIAANVK----------------- 299
               |||..|..|:|               |....::...|.:..|..:                 
Human   164 FSRKPRTLRHLPRT---------------PRPELNVAPYDPHFPAPARDGFPEPSMALPGPEALP 213

  Fly   300 LDCAI---CAAPLED-------------------FNDLKRHFRVEHDCTGYVKCCNNRYKKRTLY 342
            .:|..   ..|||.|                   :.:..   ..|.|..|...   .|:||..|.
Human   214 TECGFEPPHLAPLSDPEAPSMESPEPVKPEQGFVWQEAS---EFEADTAGSTV---ERHKKAQLD 272

  Fly   343 VDHLHCHKDPQY----------FSCQSCRKNFLNRNSQVMHMLRFHSQQQELVHQCAICEARFAK 397
            ...::...|..|          :.|:.|.|::.::.:.|.|:|..:..:.   |.|..|...|.:
Human   273 RLDINVQIDDSYLVEAGDRQKRWQCRMCEKSYTSKYNLVTHILGHNGIKP---HSCPHCSKLFKQ 334

  Fly   398 KFLLTMHLKGHKGTERPEVCDTCSKTFRTKFELSAHVKR---MHAADFTPIICDICGTHFRSKAN 459
            ...|..||..|:|| ||..|..|.|.|..    ::|:||   :| ::..|..|..||..|...:.
Human   335 PSHLQTHLLTHQGT-RPHKCQVCHKAFTQ----TSHLKRHMLLH-SEVKPYSCHFCGRGFAYPSE 393

  Fly   460 FLIHKKALHPDGPVAEVQCTLCGRWLRDERSLRKHLARHDDRDGDTKYRCLLCNAEKSSRAALSS 524
            ...| :..|..|...  .|..||........|::|||.|   .|.|.|:||.|:.....|:.|.:
Human   394 LKAH-EVKHESGRCH--VCVECGLDFSTLTQLKRHLASH---QGPTLYQCLECDKSFHYRSQLQN 452

  Fly   525 HMRYH------------------HSAKRH----------KCSLCDKEFKLPRALAEHMATHTGID 561
            ||..|                  |..|:|          ||.:|.:||.|...:..||..||.:.
Human   453 HMLKHQNVRPFVCTECGMEFSQIHHLKQHSLTHKGVKEFKCEVCGREFTLQANMKRHMLIHTSVR 517

  Fly   562 LYQCQFCTRTF------KSHANMHN----HKKKMHPNDWVRKYSQPSSSITSTAAPLAHPNHPNQ 616
            .|||..|.:||      |:|..:|:    .|.|:....:.|.|:.           |.| .|.:.
Human   518 PYQCHICFKTFVQKQTLKTHMIVHSPVKPFKCKVCGKSFNRMYNL-----------LGH-MHLHA 570

  Fly   617 PAPPAAAP---------TNLAGHM----------LPPLGGIAK 640
            .:.|...|         .||:.||          |...||.||
Human   571 GSKPFKCPYCSSKFNLKGNLSRHMKVKHGVMDIGLDSQGGWAK 613

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG11696NP_572731.1 zf-AD 2..78 CDD:285071
C2H2 Zn finger 332..349 CDD:275368 4/16 (25%)
C2H2 Zn finger 357..378 CDD:275368 6/20 (30%)
C2H2 Zn finger 388..408 CDD:275368 6/19 (32%)
C2H2 Zn finger 417..438 CDD:275368 7/23 (30%)
C2H2 Zn finger 447..465 CDD:275368 5/17 (29%)
C2H2 Zn finger 478..498 CDD:275368 7/19 (37%)
C2H2 Zn finger 509..529 CDD:275368 7/19 (37%)
C2H2 Zn finger 537..557 CDD:275368 7/19 (37%)
C2H2 Zn finger 565..583 CDD:275368 7/27 (26%)
ZNF710XP_005254963.1 C2H2 Zn finger 297..317 CDD:275368 6/19 (32%)
C2H2 Zn finger 325..345 CDD:275368 6/19 (32%)
COG5048 <335..593 CDD:227381 76/281 (27%)
zf-H2C2_2 337..362 CDD:290200 12/25 (48%)
C2H2 Zn finger 353..373 CDD:275368 7/23 (30%)
zf-H2C2_2 365..390 CDD:290200 9/25 (36%)
C2H2 Zn finger 381..401 CDD:275368 5/20 (25%)
C2H2 Zn finger 409..429 CDD:275368 7/19 (37%)
zf-C2H2 435..457 CDD:278523 8/21 (38%)
C2H2 Zn finger 437..457 CDD:275368 7/19 (37%)
zf-H2C2_2 450..474 CDD:290200 4/23 (17%)
C2H2 Zn finger 465..485 CDD:275368 3/19 (16%)
C2H2 Zn finger 493..513 CDD:275368 7/19 (37%)
zf-H2C2_2 505..530 CDD:290200 10/24 (42%)
C2H2 Zn finger 521..541 CDD:275368 6/19 (32%)
zf-H2C2_2 534..558 CDD:290200 5/23 (22%)
C2H2 Zn finger 549..569 CDD:275368 6/31 (19%)
C2H2 Zn finger 577..596 CDD:275368 5/18 (28%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165156320
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.840

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